Sertraline Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder. (Chemical Entities of Biological Interest Ontology, CHEBI_9123)
External Link http://ctdbase.org/detail.go?type=chem&acc=D020280
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Genes

43 genes/proteins interacting with the chemical Sertraline from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATF4 activating transcription factor 4
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDIT3 DNA-damage-inducible transcript 3
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
HSPA8 heat shock 70kDa protein 8
INS insulin
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VCAM1 vascular cell adhesion molecule 1