Severe Acute Respiratory Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A coronavirus infectious disease and is_a respiratory system infectious disease that results_in infection located_in respiratory tract, has_agent SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.|Severe acute respiratory syndrome is a respiratory tract infection described as a severe respiratory illness that is transmitted especially by contact with infectious material (as respiratory droplets or body fluids), is caused by a single-stranded RNA virus of the genus Coronavirus (SARS-CoV), is characterized by fever, headache, body aches, a dry cough, and hypoxia and usually by pneumonia.|A respiratory system infectious disease and is_a coronavirus infectious disease that results_in infection located_in respiratory tract, has_agent SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.|A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.|A respiratory system infectious disease that is a severe respiratory illness characterized by fever, headache, body aches, a dry cough, and hypoxia and pneumonia caused by a single-stranded RNA virus of the genus SARS coronavirus (SARS-CoV). (Experimental Factor Ontology, EFO_0000694)
External Link https://www.disgenet.org/browser/0/1/0/C1175175
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Genes

110 genes associated with the disease Severe Acute Respiratory Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACRV1 acrosomal vesicle protein 1
ADAM17 ADAM metallopeptidase domain 17
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AHSG alpha-2-HS-glycoprotein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ANPEP alanyl (membrane) aminopeptidase
ATF2 activating transcription factor 2
B2M beta-2-microglobulin
BAG3 BCL2-associated athanogene 3
BCAR3 breast cancer anti-estrogen resistance 3
BCL2L1 BCL2-like 1
BRD2 bromodomain containing 2
BST2 bone marrow stromal cell antigen 2
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD209 CD209 molecule
CDSN corneodesmosin
CKLF chemokine-like factor
CLEC4M C-type lectin domain family 4, member M
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTRL chymotrypsin-like
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
EBI3 Epstein-Barr virus induced 3
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGL2 fibrinogen-like 2
FN1 fibronectin 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNL1 guanine nucleotide binding protein-like 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPER1 G protein-coupled estrogen receptor 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAP2 GRB2-related adaptor protein 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICAM3 intercellular adhesion molecule 3
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL10 interleukin 10
IL12RB1 interleukin 12 receptor, beta 1
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IL6 interleukin 6
IRF3 interferon regulatory factor 3
ISG15 ISG15 ubiquitin-like modifier
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MERTK MER proto-oncogene, tyrosine kinase
MIP major intrinsic protein of lens fiber
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MX1 MX dynamin-like GTPase 1
MYOM2 myomesin 2
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NLRP3 NLR family, pyrin domain containing 3
NPIPB3 nuclear pore complex interacting protein family, member B3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PARK2 parkin RBR E3 ubiquitin protein ligase
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRRT2 proline-rich transmembrane protein 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1 retinoblastoma 1
RBM45 RNA binding motif protein 45
RIPK3 receptor-interacting serine-threonine kinase 3
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RTN2 reticulon 2
SARS1 seryl-tRNA synthetase 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDS serine dehydratase
SH2D3A SH2 domain containing 3A
SOCS3 suppressor of cytokine signaling 3
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
THPO thrombopoietin
TMPRSS11D transmembrane protease, serine 11D
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TPO thyroid peroxidase
TRAF3 TNF receptor-associated factor 3
TRIM25 tripartite motif containing 25
UBE2I ubiquitin-conjugating enzyme E2I
VTN vitronectin
ZNF645 zinc finger protein 645