Severe Sepsis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sepsis that results in organ dysfunction, hypotension, or hypofusion of at least one organ. (Infectious Disease Ontology, IDO_0000637)
External Link https://www.disgenet.org/browser/0/1/0/C1719672
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Genes

172 genes associated with the disease Severe Sepsis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACKR2 atypical chemokine receptor 2
ADAM10 ADAM metallopeptidase domain 10
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
APOM apolipoprotein M
AQP5 aquaporin 5
ARID5A AT rich interactive domain 5A (MRF1-like)
ARSL arylsulfatase L
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BPI bactericidal/permeability-increasing protein
BTBD8 BTB (POZ) domain containing 8
C3AR1 complement component 3a receptor 1
CAMP cathelicidin antimicrobial peptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD27 CD27 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD86 CD86 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CENPC centromere protein C
CFB complement factor B
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CTSG cathepsin G
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
DDT D-dopachrome tautomerase
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DEFB4B defensin, beta 4B
EGF epidermal growth factor
EGLN1 egl-9 family hypoxia-inducible factor 1
EPO erythropoietin
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAS6 growth arrest-specific 6
HAMP hepcidin antimicrobial peptide
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXD13 homeobox D13
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL15 interleukin 15
IL17A interleukin 17A
IL17D interleukin 17D
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL6 interleukin 6
IL7 interleukin 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRGM immunity-related GTPase family, M
KNG1 kininogen 1
LAT2 linker for activation of T cells family, member 2
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LTA lymphotoxin alpha
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
MYDGF myeloid-derived growth factor
MYLK myosin light chain kinase
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PC pyruvate carboxylase
PDCD1 programmed cell death 1
PER1 period circadian clock 1
PLG plasminogen
PON1 paraoxonase 1
PPP6R2 protein phosphatase 6, regulatory subunit 2
PPP6R3 protein phosphatase 6, regulatory subunit 3
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PTX3 pentraxin 3, long
RETN resistin
RTN1 reticulon 1
RTN4 reticulon 4
S1PR3 sphingosine-1-phosphate receptor 3
SCG2 secretogranin II
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC1 syndecan 1
SEPTIN1 septin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2D1A SH2 domain containing 1A
SIRT1 sirtuin 1
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPHK1 sphingosine kinase 1
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TMSB4X thymosin beta 4, X-linked
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNNI3 troponin I type 3 (cardiac)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM1 triggering receptor expressed on myeloid cells 1
TXN thioredoxin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
XRN1 5'-3' exoribonuclease 1
ZFYVE9 zinc finger, FYVE domain containing 9