Shox2 Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description short stature homeobox 2|This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 6474)
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Genes

31 target genes of the Shox2 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP44 Rho GTPase activating protein 44
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BARHL2 BarH-like homeobox 2
CADM1 cell adhesion molecule 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
COL1A2 collagen, type I, alpha 2
CYTH2 cytohesin 2
DOCK2 dedicator of cytokinesis 2
DPH1 diphthamide biosynthesis 1
FGF8 fibroblast growth factor 8 (androgen-induced)
HOXC12 homeobox C12
INPPL1 inositol polyphosphate phosphatase-like 1
KALRN kalirin, RhoGEF kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
MITF microphthalmia-associated transcription factor
NCAM1 neural cell adhesion molecule 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDH11X protocadherin 11 X-linked
PDE7B phosphodiesterase 7B
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRSS56 protease, serine, 56
SF1 splicing factor 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
STAC3 SH3 and cysteine rich domain 3
THTPA thiamine triphosphatase
TLE4 transducin-like enhancer of split 4
TTLL11 tubulin tyrosine ligase-like family member 11