Signaling by Hedgehog Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5358351
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Genes

136 proteins participating in the Signaling by Hedgehog pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADCY1 adenylate cyclase 1 (brain)
ADCY10 adenylate cyclase 10 (soluble)
ADCY2 adenylate cyclase 2 (brain)
ADCY3 adenylate cyclase 3
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADRM1 adhesion regulating molecule 1
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BOC BOC cell adhesion associated, oncogene regulated
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CDC73 cell division cycle 73
CDON cell adhesion associated, oncogene regulated
CSNK1A1 casein kinase 1, alpha 1
CUL1 cullin 1
CUL3 cullin 3
DERL2 derlin 2
DHH desert hedgehog
DISP2 dispatched homolog 2 (Drosophila)
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZIP1 DAZ interacting zinc finger protein 1
EFCAB7 EF-hand calcium binding domain 7
ERLEC1 endoplasmic reticulum lectin 1
EVC Ellis van Creveld protein
EVC2 Ellis van Creveld syndrome 2
FUZ fuzzy planar cell polarity protein
GAS1 growth arrest-specific 1
GAS8 growth arrest-specific 8
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GNAS GNAS complex locus
GPC5 glypican 5
GPR161 G protein-coupled receptor 161
GRK2 G protein-coupled receptor kinase 2
GSK3B glycogen synthase kinase 3 beta
HHAT hedgehog acyltransferase
HHIP hedgehog interacting protein
IFT122 intraflagellar transport 122
IFT140 intraflagellar transport 140
IFT172 intraflagellar transport 172
IFT52 intraflagellar transport 52
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
IHH indian hedgehog
INTU inturned planar cell polarity protein
IQCE IQ motif containing E
ITCH itchy E3 ubiquitin protein ligase
KIF3A kinesin family member 3A
KIF7 kinesin family member 7
MKS1 Meckel syndrome, type 1
NOTUM notum pectinacetylesterase homolog (Drosophila)
NUMB numb homolog (Drosophila)
OFD1 oral-facial-digital syndrome 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
P4HB prolyl 4-hydroxylase, beta polypeptide
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTCH1 patched 1
PTCH2 patched 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RPGRIP1L RPGRIP1-like
RPS27A ribosomal protein S27a
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEM1 SEM1 26S proteasome subunit
SHH sonic hedgehog
SKP1 S-phase kinase-associated protein 1
SMO smoothened, frizzled class receptor
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPOP speckle-type POZ protein
SPOPL speckle-type POZ protein-like
SUFU suppressor of fused homolog (Drosophila)
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TTC21B tetratricopeptide repeat domain 21B
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TULP3 tubby like protein 3
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
ULK3 unc-51 like kinase 3
VCP valosin containing protein
WDR19 WD repeat domain 19
WDR35 WD repeat domain 35