Signaling by NOTCH Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-157118
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Genes

197 proteins participating in the Signaling by NOTCH pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADRM1 adhesion regulating molecule 1
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AGO3 argonaute RISC catalytic component 3
AGO4 argonaute RISC catalytic component 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CCNC cyclin C
CCND1 cyclin D1
CDK8 cyclin-dependent kinase 8
CNTN1 contactin 1
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CUL1 cullin 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLL4 delta-like 4 (Drosophila)
DNER delta/notch-like EGF repeat containing
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EP300 E1A binding protein p300
FABP7 fatty acid binding protein 7, brain
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLT4 fms-related tyrosine kinase 4
FURIN furin (paired basic amino acid cleaving enzyme)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AB1 H2A.B variant histone 1
H2AC14 H2A clustered histone 14
H2AC18 H2A clustered histone 18
H2AC20 H2A clustered histone 20
H2AC4 H2A clustered histone 4
H2AC6 H2A clustered histone 6
H2AC7 H2A clustered histone 7
H2AJ H2A.J histone
H2AX H2A.X variant histone
H2AZ2 H2A.Z variant histone 2
H2BC1 H2B clustered histone 1
H2BC11 H2B clustered histone 11
H2BC12 H2B clustered histone 12
H2BC12L H2B clustered histone 12 like
H2BC13 H2B clustered histone 13
H2BC14 H2B clustered histone 14
H2BC15 H2B clustered histone 15
H2BC17 H2B clustered histone 17
H2BC21 H2B clustered histone 21
H2BC26 H2B clustered histone 26
H2BC3 H2B clustered histone 3
H2BC4 H2B clustered histone 4
H2BC5 H2B clustered histone 5
H2BC9 H2B clustered histone 9
H3-3A H3.3 histone A
H3C15 H3 clustered histone 15
H3C8 H3 clustered histone 8
H4C1 H4 clustered histone 1
HDAC1 histone deacetylase 1
HDAC10 histone deacetylase 10
HDAC11 histone deacetylase 11
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC6 histone deacetylase 6
HDAC7 histone deacetylase 7
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HES5 hes family bHLH transcription factor 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JAG2 jagged 2
JUN jun proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MAMLD1 mastermind-like domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIB2 mindbomb E3 ubiquitin protein ligase 2
MOV10 Mov10 RISC complex RNA helicase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBEA neurobeachin
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEURL1B neuralized E3 ubiquitin protein ligase 1B
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH2NLA notch 2 N-terminal like A
NOTCH2NLB notch 2 N-terminal like B
NOTCH2NLC notch 2 N-terminal like C
NOTCH3 notch 3
NOTCH4 notch 4
NUMB numb homolog (Drosophila)
PBX1 pre-B-cell leukemia homeobox 1
PLXND1 plexin D1
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
PRKCI protein kinase C, iota
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTCRA pre T-cell antigen receptor alpha
RAB6A RAB6A, member RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPS27A ribosomal protein S27a
RUNX1 runt-related transcription factor 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEM1 SEM1 26S proteasome subunit
SIRT6 sirtuin 6
SKP1 S-phase kinase-associated protein 1
SMAD3 SMAD family member 3
SNW1 SNW domain containing 1
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAT1 signal transducer and activator of transcription 1, 91kDa
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TMED2 transmembrane emp24 domain trafficking protein 2
TNRC6A trinucleotide repeat containing 6A
TNRC6B trinucleotide repeat containing 6B
TNRC6C trinucleotide repeat containing 6C
TP53 tumor protein p53
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
WWC1 WW and C2 domain containing 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YBX1 Y box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta