Signaling by TGF-beta Receptor Complex Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-170834
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Genes

94 proteins participating in the Signaling by TGF-beta Receptor Complex pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNC cyclin C
CCNK cyclin K
CCNT1 cyclin T1
CCNT2 cyclin T2
CDK8 cyclin-dependent kinase 8
CDK9 cyclin-dependent kinase 9
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CGN cingulin
COL1A2 collagen, type I, alpha 2
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EP300 E1A binding protein p300
F11R F11 receptor
FBN1 fibrillin 1
FKBP1A FK506 binding protein 1A, 12kDa
FURIN furin (paired basic amino acid cleaving enzyme)
HDAC1 histone deacetylase 1
ITGA8 integrin, alpha 8
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
ITGB8 integrin, beta 8
JUNB jun B proto-oncogene
LTBP1 latent transforming growth factor beta binding protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LTBP3 latent transforming growth factor beta binding protein 3
LTBP4 latent transforming growth factor beta binding protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MEN1 multiple endocrine neoplasia I
MTMR4 myotubularin related protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARP1 poly (ADP-ribose) polymerase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCZ protein kinase C, zeta
RBL1 retinoblastoma-like 1
RHOA ras homolog family member A
RNF111 ring finger protein 111
RPS27A ribosomal protein S27a
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNW1 SNW domain containing 1
SP1 Sp1 transcription factor
STAT1 signal transducer and activator of transcription 1, 91kDa
STRAP serine/threonine kinase receptor associated protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TGIF2 TGFB-induced factor homeobox 2
TRIM33 tripartite motif containing 33
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2M ubiquitin-conjugating enzyme E2M
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP25 ubiquitin specific peptidase 25
USP9X ubiquitin specific peptidase 9, X-linked
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1
YBX1 Y box binding protein 1
ZFYVE9 zinc finger, FYVE domain containing 9