Signaling pathways regulating pluripotency of stem cells Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Pluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date include embryonic stem (ES) and induced pluripotent stem (iPS) cells. ES cells are derived from the inner cell mass (ICM) of blastocyst-stage embryos. iPS cells are generated by reprogramming somatic cells back to pluripotent state with defined reprogramming factors, Oct4, Sox2, Klf4 and c-Myc (also known as Yamanaka factors). PSCs including ES cells and iPS cells are categorized into two groups by their morphology, gene expression profile and external signal dependence. Conventional mouse-type ES/iPS cells are called 'naive state' cells. They are mainly maintained under the control of LIF and BMP signaling. On the other hand, human-type ES/iPS cells, which are in need of Activin and FGF signaling, are termed 'primed state'. However, these signaling pathways converge towards the activation of a core transcriptional network that is similar in both groups and involves OCt4, Nanog and Sox2. The three transcription factors and their downstream target genes coordinately promote self-renewal and pluripotency. (Kyoto Encyclopedia of Genes and Genomes, hsa04550)
External Link https://www.kegg.jp/entry/hsa04550
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Genes

141 proteins participating in the Signaling pathways regulating pluripotency of stem cells pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR1C activin A receptor, type IC
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AXIN1 axin 1
AXIN2 axin 2
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CLSTN1 calsyntenin 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLX5 distal-less homeobox 5
DUSP9 dual specificity phosphatase 9
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
FGF13 fibroblast growth factor 13
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HAND1 heart and neural crest derivatives expressed 1
HESX1 HESX homeobox 1
HOXA1 homeobox A1
HOXB1 homeobox B1
HOXD1 homeobox D1
HRAS Harvey rat sarcoma viral oncogene homolog
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INHBB inhibin, beta B
INHBC inhibin, beta C
INHBE inhibin, beta E
ISL1 ISL LIM homeobox 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JARID2 jumonji, AT rich interactive domain 2
KAT6A K(lysine) acetyltransferase 6A
KLF4 Kruppel-like factor 4 (gut)
LEFTY1 left-right determination factor 1
LEFTY2 left-right determination factor 2
LHX5 LIM homeobox 5
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LNCEGFL7OS lncRNA EGFL7 opposite strand
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MEIS1 Meis homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYF5 myogenic factor 5
NANOG Nanog homeobox
NANOGP8 Nanog homeobox pseudogene 8
NEUROG1 neurogenin 1
NODAL nodal growth differentiation factor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
ONECUT1 one cut homeobox 1
OTX1 orthodenticle homeobox 1
PAX6 paired box 6
PCGF1 polycomb group ring finger 1
PCGF2 polycomb group ring finger 2
PCGF3 polycomb group ring finger 3
PCGF5 polycomb group ring finger 5
PCGF6 polycomb group ring finger 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POU5F1 POU class 5 homeobox 1
POU5F1B POU class 5 homeobox 1B
PROC protein C (inactivator of coagulation factors Va and VIIIa)
REST RE1-silencing transcription factor
RNASE3 ribonuclease, RNase A family, 3
SETDB1 SET domain, bifurcated 1
SKIL SKI-like proto-oncogene
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD9 SMAD family member 9
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SOX2 SRY (sex determining region Y)-box 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBX3 T-box 3
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B
ZFHX3 zinc finger homeobox 3
ZIC3 Zic family member 3