| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135398744 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Sildenafil relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| USP19 | ubiquitin specific peptidase 19 | 2.75 |
| NCOR1 | nuclear receptor corepressor 1 | 1.59 |
| PDE9A | phosphodiesterase 9A | 1.15 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 1.11 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.93 |
| PUM2 | pumilio RNA-binding family member 2 | 0.64 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.63 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.61 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.6 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | 0.58 |
| PLCB4 | phospholipase C, beta 4 | 0.57 |
| PPFIA3 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 | 0.56 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | 0.55 |
| DEPDC1 | DEP domain containing 1 | 0.53 |
| ATF6B | activating transcription factor 6 beta | 0.53 |
| OAF | OAF homolog (Drosophila) | 0.51 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.48 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.47 |
| RARA | retinoic acid receptor, alpha | 0.46 |
| PGBD2 | piggyBac transposable element derived 2 | 0.43 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.42 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.42 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.42 |
| SP100 | SP100 nuclear antigen | 0.42 |
| SCRN3 | secernin 3 | 0.41 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.4 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.39 |
| MAP1A | microtubule-associated protein 1A | 0.39 |
| FASTK | Fas-activated serine/threonine kinase | 0.39 |
| ZNF397 | zinc finger protein 397 | 0.39 |
| DUSP22 | dual specificity phosphatase 22 | 0.39 |
| BCDIN3D | BCDIN3 domain containing | 0.37 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.37 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.37 |
| CDC25A | cell division cycle 25A | 0.36 |
| CXXC5 | CXXC finger protein 5 | 0.36 |
| SMIM26 | small integral membrane protein 26 | 0.36 |
| HDIP1 | HDAC and MIER1 interacting protein 1 | 0.36 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 0.36 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | 0.35 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.35 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 0.35 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 0.35 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.35 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.34 |
| CCDC77 | coiled-coil domain containing 77 | 0.34 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.34 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.33 |
| BCL9 | B-cell CLL/lymphoma 9 | 0.33 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | 0.33 |
| BBS4 | Bardet-Biedl syndrome 4 | 0.33 |
| ZNF431 | zinc finger protein 431 | 0.33 |
| LMO4 | LIM domain only 4 | 0.32 |
| ZNF267 | zinc finger protein 267 | 0.32 |
| MYCBP | MYC binding protein | 0.32 |
| SIKE1 | suppressor of IKBKE 1 | 0.32 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.31 |
| ENO1 | enolase 1, (alpha) | 0.31 |
| KSR1 | kinase suppressor of ras 1 | 0.31 |
| AZIN1 | antizyme inhibitor 1 | 0.31 |
| ALMS1 | Alstrom syndrome protein 1 | 0.31 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.31 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.3 |
| KIFC3 | kinesin family member C3 | 0.3 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.3 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.3 |
| USP43 | ubiquitin specific peptidase 43 | 0.3 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.3 |
| NFYB | nuclear transcription factor Y, beta | 0.3 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.3 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.29 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.29 |
| ZNF2 | zinc finger protein 2 | 0.29 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 0.29 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.28 |
| MGA | MGA, MAX dimerization protein | 0.28 |
| MDM4 | MDM4, p53 regulator | 0.28 |
| KALRN | kalirin, RhoGEF kinase | 0.28 |
| SNX19 | sorting nexin 19 | 0.28 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.28 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.27 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.27 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.27 |
| C17ORF53 | chromosome 17 open reading frame 53 | 0.27 |
| SPATA2L | spermatogenesis associated 2-like | 0.27 |
| ZBED1 | zinc finger, BED-type containing 1 | 0.27 |
| BORA | bora, aurora kinase A activator | 0.27 |
| ZNF511 | zinc finger protein 511 | 0.27 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.27 |
| APOLTP | apolipoprotein lipid transfer particle homolog | 0.27 |
| SUCO | SUN domain containing ossification factor | 0.27 |
| RWDD2B | RWD domain containing 2B | 0.27 |
| MADD | MAP-kinase activating death domain | 0.27 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.26 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.26 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.26 |
| HINT1 | histidine triad nucleotide binding protein 1 | 0.26 |
| HIST2H2AB | histone cluster 2, H2ab | 0.26 |
| BTG3 | BTG family, member 3 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | -1.83 |
| KIF26A | kinesin family member 26A | -1.57 |
| ZNF654 | zinc finger protein 654 | -0.82 |
| ACTBL2 | actin, beta-like 2 | -0.73 |
| ZNF524 | zinc finger protein 524 | -0.66 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.65 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.56 |
| ZNF428 | zinc finger protein 428 | -0.56 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.52 |
| ITGB8 | integrin, beta 8 | -0.52 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.5 |
| KLHL36 | kelch-like family member 36 | -0.49 |
| ABHD18 | abhydrolase domain containing 18 | -0.47 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.46 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.46 |
| SNTA1 | syntrophin, alpha 1 | -0.45 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.43 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.43 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.42 |
| MICB | MHC class I polypeptide-related sequence B | -0.41 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.4 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.4 |
| PRR36 | proline rich 36 | -0.4 |
| DIPK1B | divergent protein kinase domain 1B | -0.39 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.39 |
| ZNF580 | zinc finger protein 580 | -0.39 |
| TBC1D31 | TBC1 domain family, member 31 | -0.37 |
| WDR90 | WD repeat domain 90 | -0.36 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.36 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.36 |
| DNAH8 | dynein, axonemal, heavy chain 8 | -0.36 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.35 |
| CCDC102A | coiled-coil domain containing 102A | -0.34 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.34 |
| TMCO4 | transmembrane and coiled-coil domains 4 | -0.34 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.34 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.33 |
| LYST | lysosomal trafficking regulator | -0.33 |
| ATXN3 | ataxin 3 | -0.33 |
| RFX7 | regulatory factor X, 7 | -0.33 |
| ATL1 | atlastin GTPase 1 | -0.33 |
| KIAA1109 | KIAA1109 | -0.32 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.32 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | -0.32 |
| WDR53 | WD repeat domain 53 | -0.32 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.32 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -0.32 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.31 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -0.31 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.31 |
| LOXL2 | lysyl oxidase-like 2 | -0.3 |
| ZNF557 | zinc finger protein 557 | -0.3 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.3 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.3 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.3 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.3 |
| C11ORF95 | chromosome 11 open reading frame 95 | -0.3 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.3 |
| DMD | dystrophin | -0.29 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.29 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.29 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.29 |
| ZNF264 | zinc finger protein 264 | -0.29 |
| CHKB | choline kinase beta | -0.28 |
| RTN4R | reticulon 4 receptor | -0.28 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.28 |
| ZNF304 | zinc finger protein 304 | -0.28 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.28 |
| NRM | nurim (nuclear envelope membrane protein) | -0.28 |
| ARHGAP31 | Rho GTPase activating protein 31 | -0.27 |
| TMEM179B | transmembrane protein 179B | -0.27 |
| MCOLN1 | mucolipin 1 | -0.27 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.26 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | -0.26 |
| TATDN2 | TatD DNase domain containing 2 | -0.26 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | -0.26 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.25 |
| DEDD | death effector domain containing | -0.25 |
| OTC | ornithine carbamoyltransferase | -0.25 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.25 |
| GPATCH3 | G patch domain containing 3 | -0.25 |
| KLK6 | kallikrein-related peptidase 6 | -0.24 |
| FKBPL | FK506 binding protein like | -0.24 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | -0.24 |
| TRIM2 | tripartite motif containing 2 | -0.24 |
| FAM76B | family with sequence similarity 76, member B | -0.24 |
| VWA3B | von Willebrand factor A domain containing 3B | -0.24 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.24 |
| ADIRF | adipogenesis regulatory factor | -0.24 |
| TMEM186 | transmembrane protein 186 | -0.24 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.24 |
| SETD5 | SET domain containing 5 | -0.23 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | -0.23 |
| FADS1 | fatty acid desaturase 1 | -0.23 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.23 |
| ATP9A | ATPase, class II, type 9A | -0.23 |
| ANO8 | anoctamin 8 | -0.23 |
| SLC9A7 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 | -0.23 |
| GRAMD4 | GRAM domain containing 4 | -0.23 |
