Sildenafil_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sildenafil_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.131275
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.093248
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0784395
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0715026
NAV1 neuron navigator 1 0.0535303
AUTS2 autism susceptibility candidate 2 0.0532307
DST dystonin 0.051118
PODXL podocalyxin-like 0.0506752
FNDC3B fibronectin type III domain containing 3B 0.0502001
FBXL7 F-box and leucine-rich repeat protein 7 0.0483808
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0473724
COL5A1 collagen, type V, alpha 1 0.0471343
CDH13 cadherin 13 0.0433797
SLC39A11 solute carrier family 39, member 11 0.0431076
GLS2 glutaminase 2 (liver, mitochondrial) 0.0390955
NAV2 neuron navigator 2 0.0387582
ATP13A3 ATPase type 13A3 0.0373525
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0370524
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0361297
PRELID2 PRELI domain containing 2 0.0355693
FBN1 fibrillin 1 0.0355525
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0354192
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0339545
EGFR epidermal growth factor receptor 0.032916
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0328612
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0319591
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0313834
RUNX1 runt-related transcription factor 1 0.0304845
ANKRD11 ankyrin repeat domain 11 0.0302613
HDAC9 histone deacetylase 9 0.0298706
SMYD3 SET and MYND domain containing 3 0.0298187
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290664
SEPTIN9 septin 9 0.0288171
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0282584
MSN moesin 0.0280846
MYH9 myosin, heavy chain 9, non-muscle 0.0279919
MACF1 microtubule-actin crosslinking factor 1 0.0275573
APP amyloid beta (A4) precursor protein 0.0274965
NCOR2 nuclear receptor corepressor 2 0.0258574
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0257556
FNIP1 folliculin interacting protein 1 0.0255714
GPC6 glypican 6 0.0254962
ANKRD36 ankyrin repeat domain 36 0.0254025
NEK7 NIMA-related kinase 7 0.0245572
PBX3 pre-B-cell leukemia homeobox 3 0.0243277
TAOK1 TAO kinase 1 0.0236414
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0234482
PICALM phosphatidylinositol binding clathrin assembly protein 0.0228985
SDK1 sidekick cell adhesion molecule 1 0.0225826
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0224943
SOD2 superoxide dismutase 2, mitochondrial 0.022438
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0223318
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0221645
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0220352
GLIS3 GLIS family zinc finger 3 0.0219004
JMJD1C jumonji domain containing 1C 0.0217864
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.021533
EFNA5 ephrin-A5 0.0211773
CYTH3 cytohesin 3 0.0211575
COPA coatomer protein complex, subunit alpha 0.0209539
PLEC plectin 0.0209226
SPAG9 sperm associated antigen 9 0.0207299
TNIP1 TNFAIP3 interacting protein 1 0.020603
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0204227
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0204118
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0201823
YEATS2 YEATS domain containing 2 0.0200024
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0199352
SBF2 SET binding factor 2 0.0198788
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0198551
RNF144A ring finger protein 144A 0.0197325
USP34 ubiquitin specific peptidase 34 0.0194118
MPRIP myosin phosphatase Rho interacting protein 0.019347
ATXN1 ataxin 1 0.0192953
SP3 Sp3 transcription factor 0.0192728
NBAS neuroblastoma amplified sequence 0.0191958
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0190735
KDM6A lysine (K)-specific demethylase 6A 0.018943
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0187561
AHNAK2 AHNAK nucleoprotein 2 0.018571
CYLD cylindromatosis (turban tumor syndrome) 0.018521
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0183692
ZNF638 zinc finger protein 638 0.0183637
PRKCE protein kinase C, epsilon 0.0183253
ADAM17 ADAM metallopeptidase domain 17 0.01829
FSD1L fibronectin type III and SPRY domain containing 1-like 0.0182649
TENM3 teneurin transmembrane protein 3 0.0179098
FLNA filamin A, alpha 0.0179032
SH3RF1 SH3 domain containing ring finger 1 0.0177283
MYOF myoferlin 0.0175439
VEGFC vascular endothelial growth factor C 0.0175315
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0174323
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0174063
JAZF1 JAZF zinc finger 1 0.0174005
DENND5A DENN/MADD domain containing 5A 0.0173137
FCHSD2 FCH and double SH3 domains 2 0.0172575
ZC3H11A zinc finger CCCH-type containing 11A 0.0172305
WDFY3 WD repeat and FYVE domain containing 3 0.0171356
AFDN afadin, adherens junction formation factor 0.0170087
DCLK2 doublecortin-like kinase 2 0.0169057

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.302962
TMSB10 thymosin beta 10 -0.286474
MT2A metallothionein 2A -0.238594
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212331
PTMA prothymosin, alpha -0.102788
AKAP12 A kinase (PRKA) anchor protein 12 -0.0953684
CSTB cystatin B (stefin B) -0.0907637
S100A10 S100 calcium binding protein A10 -0.0869109
HLA-B major histocompatibility complex, class I, B -0.081546
S100A6 S100 calcium binding protein A6 -0.0794669
B2M beta-2-microglobulin -0.0788893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0746346
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0665018
TPT1 tumor protein, translationally-controlled 1 -0.0634747
IFITM3 interferon induced transmembrane protein 3 -0.0621392
FTL ferritin, light polypeptide -0.0599894
MARCKS myristoylated alanine-rich protein kinase C substrate -0.059792
LMNA lamin A/C -0.0526128
PLAT plasminogen activator, tissue -0.0486535
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0464659
NDRG1 N-myc downstream regulated 1 -0.0463587
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0453542
RPS6 ribosomal protein S6 -0.0436333
RPL12 ribosomal protein L12 -0.0426689
RPL23 ribosomal protein L23 -0.0424347
EIF1 eukaryotic translation initiation factor 1 -0.0422426
RPLP1 ribosomal protein, large, P1 -0.0404123
UBC ubiquitin C -0.0401031
RPLP2 ribosomal protein, large, P2 -0.0396344
RPL35A ribosomal protein L35a -0.0391558
IGFBP3 insulin-like growth factor binding protein 3 -0.0382845
RPS8 ribosomal protein S8 -0.0380303
RPL28 ribosomal protein L28 -0.0374807
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0374173
MT1X metallothionein 1X -0.0373663
IFITM1 interferon induced transmembrane protein 1 -0.0368053
ZFP36L1 ZFP36 ring finger protein-like 1 -0.036425
RPL36 ribosomal protein L36 -0.0361919
STC1 stanniocalcin 1 -0.0358841
LGALS1 lectin, galactoside-binding, soluble, 1 -0.035883
RPS19 ribosomal protein S19 -0.035269
RPL37A ribosomal protein L37a -0.0351954
RPL34 ribosomal protein L34 -0.0351148
TMSB4X thymosin beta 4, X-linked -0.0350803
FTH1 ferritin, heavy polypeptide 1 -0.034478
RPS3 ribosomal protein S3 -0.0331998
RPL26 ribosomal protein L26 -0.0327846
CAVIN1 caveolae associated protein 1 -0.0326659
RPL19 ribosomal protein L19 -0.0323343
HSPB1 heat shock 27kDa protein 1 -0.0322686
HLA-C major histocompatibility complex, class I, C -0.0316598
RPL31 ribosomal protein L31 -0.0316235
GNAS GNAS complex locus -0.0307319
S100A11 S100 calcium binding protein A11 -0.0306882
RPS24 ribosomal protein S24 -0.0304404
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0299709
SLC38A1 solute carrier family 38, member 1 -0.0294325
MYADM myeloid-associated differentiation marker -0.0288463
SEC61G Sec61 gamma subunit -0.0288458
S100A9 S100 calcium binding protein A9 -0.0283229
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0278449
RPS27A ribosomal protein S27a -0.0276847
RPL32 ribosomal protein L32 -0.0274992
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0271653
ACTG1 actin gamma 1 -0.0271211
CD99 CD99 molecule -0.0265496
MYL12B myosin, light chain 12B, regulatory -0.0263697
RPS13 ribosomal protein S13 -0.0262698
IFI6 interferon, alpha-inducible protein 6 -0.0261663
PFN1 profilin 1 -0.0257089
RPS14 ribosomal protein S14 -0.0256843
FAM162A family with sequence similarity 162, member A -0.0253863
RPL35 ribosomal protein L35 -0.0249561
CALR calreticulin -0.0242615
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0234552
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0231075
RPS27 ribosomal protein S27 -0.0226402
KLF6 Kruppel-like factor 6 -0.0226296
RPS5 ribosomal protein S5 -0.0223361
TPI1 triosephosphate isomerase 1 -0.0223338
VDAC1 voltage-dependent anion channel 1 -0.0223071
IER3 immediate early response 3 -0.0221774
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0221386
COL1A2 collagen, type I, alpha 2 -0.0221326
RPS21 ribosomal protein S21 -0.0219502
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0215577
RPS15 ribosomal protein S15 -0.0215205
SQSTM1 sequestosome 1 -0.0214571
RPL27A ribosomal protein L27a -0.0212407
ISG15 ISG15 ubiquitin-like modifier -0.0211979
TAGLN2 transgelin 2 -0.0211939
SERF2 small EDRK-rich factor 2 -0.0211904
RPS23 ribosomal protein S23 -0.0210297
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0209375
RPL11 ribosomal protein L11 -0.0207648
ADM adrenomedullin -0.0205193
S100A4 S100 calcium binding protein A4 -0.0203766
RPLP0 ribosomal protein, large, P0 -0.0203474
RPS11 ribosomal protein S11 -0.0202982
GARS1 glycyl-tRNA synthetase 1 -0.0200983