Sildenafil_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.110129
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.107236
VIM vimentin 0.100549
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0899555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0868869
PCDH7 protocadherin 7 0.0843551
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0798416
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0793438
CELF2 CUGBP, Elav-like family member 2 0.0729102
BIRC6 baculoviral IAP repeat containing 6 0.071144
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0706583
ERRFI1 ERBB receptor feedback inhibitor 1 0.0689112
DPYD dihydropyrimidine dehydrogenase 0.0686162
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0684693
KDM3A lysine (K)-specific demethylase 3A 0.0682126
MGAT4C MGAT4 family, member C 0.0677631
FXR1 fragile X mental retardation, autosomal homolog 1 0.0669169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0630233
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0617383
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0611323
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0597652
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0558379
BIRC2 baculoviral IAP repeat containing 2 0.0552534
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0552315
CHD1 chromodomain helicase DNA binding protein 1 0.054735
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0544312
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0539324
ASPH aspartate beta-hydroxylase 0.0529218
MARCHF6 membrane associated ring-CH-type finger 6 0.0522637
PDE4D phosphodiesterase 4D, cAMP-specific 0.0516701
MATR3 matrin 3 0.0511321
EGLN1 egl-9 family hypoxia-inducible factor 1 0.050916
ECT2 epithelial cell transforming 2 0.049284
ZBTB20 zinc finger and BTB domain containing 20 0.0491504
ERBB4 erb-b2 receptor tyrosine kinase 4 0.049038
LMO7 LIM domain 7 0.0484993
PUM2 pumilio RNA-binding family member 2 0.0479545
CSNK1A1 casein kinase 1, alpha 1 0.0472599
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0462008
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0459089
ATP11A ATPase, class VI, type 11A 0.0452809
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0450757
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0445876
TENM3 teneurin transmembrane protein 3 0.0441485
CCNL1 cyclin L1 0.0441069
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0439329
ADGRG6 adhesion G protein-coupled receptor G6 0.042923
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0424168
MED13L mediator complex subunit 13-like 0.0421909
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0418436
SLC38A2 solute carrier family 38, member 2 0.0418146
RBM39 RNA binding motif protein 39 0.0417235
USP34 ubiquitin specific peptidase 34 0.0414496
CXADR coxsackie virus and adenovirus receptor 0.0413395
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0410137
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0406794
CLDN1 claudin 1 0.0406265
CDK6 cyclin-dependent kinase 6 0.0402089
FBXO11 F-box protein 11 0.0401187
TM4SF1 transmembrane 4 L six family member 1 0.039887
MARCHF4 membrane associated ring-CH-type finger 4 0.0397109
WDR43 WD repeat domain 43 0.0394324
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0394274
NEK7 NIMA-related kinase 7 0.0382468
ANKRD12 ankyrin repeat domain 12 0.0381534
THOC1 THO complex 1 0.0381372
CLTC clathrin, heavy chain (Hc) 0.037999
GASK1B golgi associated kinase 1B 0.0373462
XPO1 exportin 1 0.0372177
PGK1 phosphoglycerate kinase 1 0.0371767
NIPBL Nipped-B homolog (Drosophila) 0.0366254
SYT1 synaptotagmin I 0.0363057
KIF5B kinesin family member 5B 0.0348035
TPM3 tropomyosin 3 0.0347103
U2SURP U2 snRNP-associated SURP domain containing 0.0344493
GSK3B glycogen synthase kinase 3 beta 0.0339035
DST dystonin 0.0336059
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0333697
ARB2A ARB2 cotranscriptional regulator A 0.0330153
RAB1A RAB1A, member RAS oncogene family 0.0329453
CARD16 caspase recruitment domain family, member 16 0.0326851
MEMO1 mediator of cell motility 1 0.0324438
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0323159
CAMTA1 calmodulin binding transcription activator 1 0.0320249
EIF4A2 eukaryotic translation initiation factor 4A2 0.0318708
SLC38A1 solute carrier family 38, member 1 0.0318483
TRA2B transformer 2 beta homolog (Drosophila) 0.0309201
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0308663
ANXA1 annexin A1 0.0307671
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0305548
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0303485
PTMA prothymosin, alpha 0.0300067
RHBDD1 rhomboid domain containing 1 0.0298213
RAD21 RAD21 homolog (S. pombe) 0.0297935
SPAG9 sperm associated antigen 9 0.0297525
TRIO trio Rho guanine nucleotide exchange factor 0.0296982
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0295332
ZNF207 zinc finger protein 207 0.0294945
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0294516
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0294505

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0792301
NLGN1 neuroligin 1 -0.0726803
FTL ferritin, light polypeptide -0.0446166
CNRIP1 cannabinoid receptor interacting protein 1 -0.038648
RPS19 ribosomal protein S19 -0.0364653
PFN1 profilin 1 -0.0286365
HMGA2 high mobility group AT-hook 2 -0.0276546
EGR1 early growth response 1 -0.0272194
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.026784
RPL23 ribosomal protein L23 -0.02497
HSPB1 heat shock 27kDa protein 1 -0.0225361
HMGA1 high mobility group AT-hook 1 -0.0224051
INTS6 integrator complex subunit 6 -0.0218005
RPL36 ribosomal protein L36 -0.0217393
RPS29 ribosomal protein S29 -0.0212247
RPL12 ribosomal protein L12 -0.020374
CUX1 cut-like homeobox 1 -0.0195561
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0192587
RPS2 ribosomal protein S2 -0.0190483
RPL9 ribosomal protein L9 -0.0187509
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0185744
RPL32 ribosomal protein L32 -0.0183378
FADS2 fatty acid desaturase 2 -0.0171164
RPLP2 ribosomal protein, large, P2 -0.016848
BCHE butyrylcholinesterase -0.0168476
RPLP1 ribosomal protein, large, P1 -0.0167732
RPLP0 ribosomal protein, large, P0 -0.0165928
RPS6 ribosomal protein S6 -0.0165497
CEP112 centrosomal protein 112kDa -0.0158306
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0156498
RPS12 ribosomal protein S12 -0.0152548
POTEF POTE ankyrin domain family, member F -0.0150954
RPL28 ribosomal protein L28 -0.0148399
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0146726
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0144811
DNAH14 dynein, axonemal, heavy chain 14 -0.0144262
NABP1 nucleic acid binding protein 1 -0.0143292
RPL31 ribosomal protein L31 -0.0142004
TTC27 tetratricopeptide repeat domain 27 -0.0141868
RGS7 regulator of G-protein signaling 7 -0.0139587
UBAP2 ubiquitin associated protein 2 -0.0138982
RPL34 ribosomal protein L34 -0.013898
CSMD3 CUB and Sushi multiple domains 3 -0.0132144
ATP5F1E ATP synthase F1 subunit epsilon -0.0129146
AUTS2 autism susceptibility candidate 2 -0.0127716
RPS14 ribosomal protein S14 -0.0127424
RPL26 ribosomal protein L26 -0.0126826
TUBA1B tubulin, alpha 1b -0.0124381
PCDH9 protocadherin 9 -0.012391
RPS23 ribosomal protein S23 -0.0123792
TPT1 tumor protein, translationally-controlled 1 -0.012371
RPS17 ribosomal protein S17 -0.0120131
SPDYA speedy/RINGO cell cycle regulator family member A -0.0119741
VCL vinculin -0.0119482
RPS21 ribosomal protein S21 -0.0118998
NPAS2 neuronal PAS domain protein 2 -0.0118552
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0116803
DGUOK deoxyguanosine kinase -0.0116194
RPL8 ribosomal protein L8 -0.0116173
TTC28 tetratricopeptide repeat domain 28 -0.0115797
CPNE7 copine VII -0.0114136
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0113139
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0112359
WASF2 WAS protein family, member 2 -0.0111376
RPL35A ribosomal protein L35a -0.0111298
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0111212
KSR2 kinase suppressor of ras 2 -0.011091
RPL27 ribosomal protein L27 -0.0109605
TUBA1C tubulin, alpha 1c -0.010868
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0108605
RSU1 Ras suppressor protein 1 -0.0108011
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0106807
CLSPN claspin -0.0105256
INTS4 integrator complex subunit 4 -0.0105205
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0104519
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0104163
CREM cAMP responsive element modulator -0.0103659
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0103349
RPS13 ribosomal protein S13 -0.0102085
ZFHX4 zinc finger homeobox 4 -0.0101884
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0101806
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.01016
ARID1A AT rich interactive domain 1A (SWI-like) -0.0100567
FN1 fibronectin 1 -0.0100221
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0099904
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.00997012
PRH1 proline-rich protein HaeIII subfamily 1 -0.00996992
LOC102724023 ES1 protein homolog, mitochondrial -0.00993684
BEX3 brain expressed X-linked 3 -0.009924
IP6K1 inositol hexakisphosphate kinase 1 -0.00987923
ROMO1 reactive oxygen species modulator 1 -0.00980758
GPX4 glutathione peroxidase 4 -0.00976383
DIAPH1 diaphanous-related formin 1 -0.00967145
RPL35 ribosomal protein L35 -0.00965734
COX7C cytochrome c oxidase subunit VIIc -0.00963451
NALF1 NALCN channel auxiliary factor 1 -0.00962285
MRPL51 mitochondrial ribosomal protein L51 -0.0095677
FLNB filamin B, beta -0.00956021
TNRC6C trinucleotide repeat containing 6C -0.00946767
RAD23A RAD23 homolog A (S. cerevisiae) -0.00942198