Sildenafil_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sildenafil_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.0847301
FMN1 formin 1 0.0837134
EXT1 exostosin glycosyltransferase 1 0.0746834
FNDC3B fibronectin type III domain containing 3B 0.0588115
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0560125
MSI2 musashi RNA-binding protein 2 0.0518332
THSD4 thrombospondin, type I, domain containing 4 0.0515256
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0429128
HELZ helicase with zinc finger 0.041888
FAM13A family with sequence similarity 13, member A 0.0414235
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.041312
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0409805
DSCAM Down syndrome cell adhesion molecule 0.03958
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0369051
PSD3 pleckstrin and Sec7 domain containing 3 0.0366906
SEPTIN9 septin 9 0.033146
DTNA dystrobrevin, alpha 0.0322396
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0321911
CLTC clathrin, heavy chain (Hc) 0.0315921
COPA coatomer protein complex, subunit alpha 0.0307616
VCL vinculin 0.0290819
AHR aryl hydrocarbon receptor 0.0288492
SBF2 SET binding factor 2 0.028784
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0287116
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0286511
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0282717
SRSF1 serine/arginine-rich splicing factor 1 0.0275906
ZNF804A zinc finger protein 804A 0.027026
MAML2 mastermind-like 2 (Drosophila) 0.0269287
DST dystonin 0.0267886
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0267067
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0266471
USP3 ubiquitin specific peptidase 3 0.0264079
PLAT plasminogen activator, tissue 0.0262281
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254345
SENP6 SUMO1/sentrin specific peptidase 6 0.0252153
APP amyloid beta (A4) precursor protein 0.0249115
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0249044
PTK2 protein tyrosine kinase 2 0.0246973
ZMIZ1 zinc finger, MIZ-type containing 1 0.0242428
LIMCH1 LIM and calponin homology domains 1 0.0240375
ANGPT1 angiopoietin 1 0.0237459
EIF4B eukaryotic translation initiation factor 4B 0.0236579
NPAS2 neuronal PAS domain protein 2 0.023436
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0232276
ANKRD11 ankyrin repeat domain 11 0.023102
COL3A1 collagen, type III, alpha 1 0.0229512
WDR70 WD repeat domain 70 0.0228774
SOS1 son of sevenless homolog 1 (Drosophila) 0.022433
CPED1 cadherin-like and PC-esterase domain containing 1 0.0224157
ANTXR2 anthrax toxin receptor 2 0.022338
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0223244
PRKCA protein kinase C, alpha 0.022277
NREP neuronal regeneration related protein 0.0222249
AUTS2 autism susceptibility candidate 2 0.0218546
MED13 mediator complex subunit 13 0.0216821
ITGA1 integrin, alpha 1 0.0216363
KMT2C lysine (K)-specific methyltransferase 2C 0.0215773
KDM3A lysine (K)-specific demethylase 3A 0.0215532
LPIN1 lipin 1 0.0215127
NF1 neurofibromin 1 0.0211836
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0211423
NIPBL Nipped-B homolog (Drosophila) 0.021038
CARD16 caspase recruitment domain family, member 16 0.0209998
TCERG1 transcription elongation regulator 1 0.0208325
NUP153 nucleoporin 153kDa 0.0207051
AHCTF1 AT hook containing transcription factor 1 0.02033
COL4A5 collagen, type IV, alpha 5 0.0202704
ARHGAP9 Rho GTPase activating protein 9 0.0202507
NPR2 natriuretic peptide receptor 2 0.0201783
AFF4 AF4/FMR2 family, member 4 0.0200165
XPO1 exportin 1 0.0200162
NRIP1 nuclear receptor interacting protein 1 0.0199536
NBEA neurobeachin 0.0197457
BCLAF1 BCL2-associated transcription factor 1 0.0197363
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0196399
AKAP12 A kinase (PRKA) anchor protein 12 0.0195817
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0194301
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193747
ZC3H11A zinc finger CCCH-type containing 11A 0.0193539
KIAA1217 KIAA1217 0.0191061
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0190747
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0188226
HSPA8 heat shock 70kDa protein 8 0.0187369
CRH corticotropin releasing hormone 0.018698
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0186475
TBC1D5 TBC1 domain family, member 5 0.0185819
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0184778
ANTXR1 anthrax toxin receptor 1 0.0182886
HMBOX1 homeobox containing 1 0.0182666
ZFAND3 zinc finger, AN1-type domain 3 0.0182159
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0181253
PCBP3 poly(rC) binding protein 3 0.0181039
ZBTB20 zinc finger and BTB domain containing 20 0.0180914
GOLGB1 golgin B1 0.0180737
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0180397
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0179994
MORF4L1 mortality factor 4 like 1 0.0179141
BLTP1 bridge-like lipid transfer protein family member 1 0.0178512
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.0177423

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.312854
IGF2 insulin-like growth factor 2 -0.268673
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.252973
RPS6 ribosomal protein S6 -0.112561
RPL23 ribosomal protein L23 -0.109993
VIM vimentin -0.102906
RPL35A ribosomal protein L35a -0.0910199
RPL19 ribosomal protein L19 -0.0841789
RPLP1 ribosomal protein, large, P1 -0.0801528
B2M beta-2-microglobulin -0.0733156
PTMA prothymosin, alpha -0.063504
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0602968
EIF1 eukaryotic translation initiation factor 1 -0.0555091
TMSB10 thymosin beta 10 -0.0510094
RPL37A ribosomal protein L37a -0.0501967
RPS19 ribosomal protein S19 -0.0500915
RPL38 ribosomal protein L38 -0.047886
RPS23 ribosomal protein S23 -0.0469753
RPS27 ribosomal protein S27 -0.046136
FTL ferritin, light polypeptide -0.04554
RPL34 ribosomal protein L34 -0.0437982
RPL36 ribosomal protein L36 -0.0435461
RPS3 ribosomal protein S3 -0.0418299
RPL12 ribosomal protein L12 -0.0412551
GATA3 GATA binding protein 3 -0.0406669
RPL32 ribosomal protein L32 -0.0396839
RPS12 ribosomal protein S12 -0.0392322
ACTG1 actin gamma 1 -0.0382867
RPS14 ribosomal protein S14 -0.0380178
RPLP0 ribosomal protein, large, P0 -0.0379111
EEF2 eukaryotic translation elongation factor 2 -0.0377394
TPT1 tumor protein, translationally-controlled 1 -0.0370134
BPTF bromodomain PHD finger transcription factor -0.0368923
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0356547
RPL26 ribosomal protein L26 -0.0350524
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0340387
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0335314
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0328189
RPS29 ribosomal protein S29 -0.0326658
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0323131
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0314133
SYT1 synaptotagmin I -0.0307922
RPL37 ribosomal protein L37 -0.0305896
S100A9 S100 calcium binding protein A9 -0.0299214
RPS15 ribosomal protein S15 -0.0295032
RPL13A ribosomal protein L13a -0.0294298
PRRC2C proline-rich coiled-coil 2C -0.029134
DEK DEK proto-oncogene -0.0289974
POTEF POTE ankyrin domain family, member F -0.0289254
TBX2 T-box 2 -0.0284709
RPL27 ribosomal protein L27 -0.0284223
RPS5 ribosomal protein S5 -0.0282362
RPL36A ribosomal protein L36a -0.027864
RPL7 ribosomal protein L7 -0.0278594
RPL18 ribosomal protein L18 -0.0274991
RPS13 ribosomal protein S13 -0.0273605
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0272252
TRIB2 tribbles pseudokinase 2 -0.0270433
RPL35 ribosomal protein L35 -0.026992
S100A6 S100 calcium binding protein A6 -0.02668
GNAS GNAS complex locus -0.0262073
RPLP2 ribosomal protein, large, P2 -0.0251452
BCAS3 breast carcinoma amplified sequence 3 -0.0249301
PHOX2B paired-like homeobox 2b -0.0248702
FNBP1 formin binding protein 1 -0.0245974
RPL9 ribosomal protein L9 -0.0244906
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0244723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0243776
RPL31 ribosomal protein L31 -0.0243633
PCBP2 poly(rC) binding protein 2 -0.0243567
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0241584
KTN1 kinectin 1 (kinesin receptor) -0.0239665
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0233863
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0230599
TTC17 tetratricopeptide repeat domain 17 -0.0230365
IFI16 interferon, gamma-inducible protein 16 -0.0224924
MT2A metallothionein 2A -0.0222927
RPS16 ribosomal protein S16 -0.022152
DCAF7 DDB1 and CUL4 associated factor 7 -0.0220647
RPS25 ribosomal protein S25 -0.0216384
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0214829
CD36 CD36 molecule (thrombospondin receptor) -0.0214389
CCAR1 cell division cycle and apoptosis regulator 1 -0.0211751
MAP1B microtubule-associated protein 1B -0.021075
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.021068
GLG1 golgi glycoprotein 1 -0.0210406
ZMYM2 zinc finger, MYM-type 2 -0.0209212
RPS21 ribosomal protein S21 -0.0209015
RACK1 receptor for activated C kinase 1 -0.0206697
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0204086
RPL8 ribosomal protein L8 -0.0203629
EGR1 early growth response 1 -0.0203319
RPL15 ribosomal protein L15 -0.0202413
RPS24 ribosomal protein S24 -0.0202333
PGK1 phosphoglycerate kinase 1 -0.0202084
TPI1 triosephosphate isomerase 1 -0.0200713
DLC1 DLC1 Rho GTPase activating protein -0.0200697
EEF1G eukaryotic translation elongation factor 1 gamma -0.0200376
RPS20 ribosomal protein S20 -0.0199598
TXNIP thioredoxin interacting protein -0.0199197