Sildenafil_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.1451
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.133858
COL6A3 collagen, type VI, alpha 3 0.110826
CADM1 cell adhesion molecule 1 0.110275
FNDC3B fibronectin type III domain containing 3B 0.0976336
CDH13 cadherin 13 0.09086
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0903843
FN1 fibronectin 1 0.0751823
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0729899
ATP13A3 ATPase type 13A3 0.0705407
ZFAND3 zinc finger, AN1-type domain 3 0.0608246
ANKRD11 ankyrin repeat domain 11 0.054701
NALF1 NALCN channel auxiliary factor 1 0.0540072
PTK2 protein tyrosine kinase 2 0.0494178
SOD2 superoxide dismutase 2, mitochondrial 0.0449667
MYH9 myosin, heavy chain 9, non-muscle 0.0440694
FMNL2 formin-like 2 0.0417365
TSC22D2 TSC22 domain family, member 2 0.041039
PLEC plectin 0.040822
NAV2 neuron navigator 2 0.0404454
TFG TRK-fused gene 0.0394589
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0379489
CAMTA1 calmodulin binding transcription activator 1 0.0378385
USP3 ubiquitin specific peptidase 3 0.0371013
GSK3B glycogen synthase kinase 3 beta 0.0343113
LPP LIM domain containing preferred translocation partner in lipoma 0.0330559
EXT1 exostosin glycosyltransferase 1 0.0322593
MACF1 microtubule-actin crosslinking factor 1 0.0320781
QKI QKI, KH domain containing, RNA binding 0.0317234
RASA2 RAS p21 protein activator 2 0.0307069
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0304944
ADAM17 ADAM metallopeptidase domain 17 0.0293354
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0281579
NAMPT nicotinamide phosphoribosyltransferase 0.0280435
EEF2 eukaryotic translation elongation factor 2 0.0279081
MED13L mediator complex subunit 13-like 0.0270819
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0264826
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0263168
RICTOR RPTOR independent companion of MTOR, complex 2 0.0262237
PDE10A phosphodiesterase 10A 0.0259768
PRELID2 PRELI domain containing 2 0.0254498
APP amyloid beta (A4) precursor protein 0.0253011
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0251196
SMYD3 SET and MYND domain containing 3 0.0251074
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0250748
MARCHF6 membrane associated ring-CH-type finger 6 0.0250281
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0248552
ANKRD10 ankyrin repeat domain 10 0.0244402
JARID2 jumonji, AT rich interactive domain 2 0.024433
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0243309
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0241522
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0240469
CCNY cyclin Y 0.0238463
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0237985
FXR1 fragile X mental retardation, autosomal homolog 1 0.0235246
PARD3 par-3 family cell polarity regulator 0.0235027
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0232782
EPS8 epidermal growth factor receptor pathway substrate 8 0.023197
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0229989
SPAG9 sperm associated antigen 9 0.0226806
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0224757
GLS2 glutaminase 2 (liver, mitochondrial) 0.0224188
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0220253
GRB10 growth factor receptor-bound protein 10 0.0219094
ADAM9 ADAM metallopeptidase domain 9 0.0217954
BBX bobby sox homolog (Drosophila) 0.021677
MRTFA myocardin related transcription factor A 0.0212213
AHNAK AHNAK nucleoprotein 0.0212037
RAB7A RAB7A, member RAS oncogene family 0.0210744
RHEB Ras homolog enriched in brain 0.0210408
SNX9 sorting nexin 9 0.020965
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0209465
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0208814
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0206954
PTBP2 polypyrimidine tract binding protein 2 0.0206246
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0205398
NBAS neuroblastoma amplified sequence 0.020485
OGA O-GlcNAcase 0.0204545
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0204442
PICALM phosphatidylinositol binding clathrin assembly protein 0.0203504
RAB1A RAB1A, member RAS oncogene family 0.020271
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0202009
TENT4A terminal nucleotidyltransferase 4A 0.0201086
COG5 component of oligomeric golgi complex 5 0.0200945
RYK receptor-like tyrosine kinase 0.0197327
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0195307
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0194362
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0194333
DENND5A DENN/MADD domain containing 5A 0.0194168
TMEM39A transmembrane protein 39A 0.0194026
ZEB1 zinc finger E-box binding homeobox 1 0.0192395
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0191831
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.018888
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0188486
PDLIM5 PDZ and LIM domain 5 0.0187563
ZNF292 zinc finger protein 292 0.0184702
VCL vinculin 0.0184235
MBNL1 muscleblind-like splicing regulator 1 0.0183641
MTMR3 myotubularin related protein 3 0.0182953
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0181211

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230405
MT2A metallothionein 2A -0.207604
VIM vimentin -0.17557
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.141413
STC1 stanniocalcin 1 -0.1229
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.10447
IGFBP3 insulin-like growth factor binding protein 3 -0.100077
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.097524
TGFBI transforming growth factor, beta-induced, 68kDa -0.0957764
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0788558
VEGFA vascular endothelial growth factor A -0.0769491
TMSB10 thymosin beta 10 -0.0744504
COL1A1 collagen, type I, alpha 1 -0.0730315
NDRG1 N-myc downstream regulated 1 -0.0685166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0678212
CD44 CD44 molecule (Indian blood group) -0.0669628
LOX lysyl oxidase -0.0572729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0548165
LOXL2 lysyl oxidase-like 2 -0.0507207
RPS6 ribosomal protein S6 -0.0501844
RPS2 ribosomal protein S2 -0.0499828
S100A9 S100 calcium binding protein A9 -0.0497881
FTL ferritin, light polypeptide -0.0487395
PTMA prothymosin, alpha -0.0481295
EIF1 eukaryotic translation initiation factor 1 -0.0476996
B2M beta-2-microglobulin -0.0471336
RPS8 ribosomal protein S8 -0.047026
IGFBP7 insulin-like growth factor binding protein 7 -0.0467736
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0464323
COL1A2 collagen, type I, alpha 2 -0.0458104
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0444177
INHBA inhibin, beta A -0.0430055
IFI6 interferon, alpha-inducible protein 6 -0.0417191
IER3 immediate early response 3 -0.0390493
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0367527
TM4SF1 transmembrane 4 L six family member 1 -0.0352693
PSD3 pleckstrin and Sec7 domain containing 3 -0.0349932
HLA-B major histocompatibility complex, class I, B -0.0327107
RPL37A ribosomal protein L37a -0.032426
RPS3 ribosomal protein S3 -0.0323841
RPS19 ribosomal protein S19 -0.0316787
MT1X metallothionein 1X -0.0308532
RPS13 ribosomal protein S13 -0.0307268
RPL26 ribosomal protein L26 -0.0304863
S100A6 S100 calcium binding protein A6 -0.0287259
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0286525
UBC ubiquitin C -0.0284998
RPLP2 ribosomal protein, large, P2 -0.0281689
RPL28 ribosomal protein L28 -0.0280498
RPL8 ribosomal protein L8 -0.0279514
VCAN versican -0.0274863
ECE1 endothelin converting enzyme 1 -0.0269724
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0266767
RPL32 ribosomal protein L32 -0.0265964
WWTR1 WW domain containing transcription regulator 1 -0.0261522
IL6 interleukin 6 -0.0259622
RPL36 ribosomal protein L36 -0.025761
TPT1 tumor protein, translationally-controlled 1 -0.0250448
LDHA lactate dehydrogenase A -0.0248812
RPS12 ribosomal protein S12 -0.0246531
TMSB4X thymosin beta 4, X-linked -0.0242606
RPS27A ribosomal protein S27a -0.0240031
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0238161
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0234501
RPL18 ribosomal protein L18 -0.0232212
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0229825
RPL12 ribosomal protein L12 -0.0227387
ENO1 enolase 1, (alpha) -0.0226902
RPLP1 ribosomal protein, large, P1 -0.0224264
ACTG1 actin gamma 1 -0.0222776
LMAN1 lectin, mannose-binding, 1 -0.0221157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0220303
S100A10 S100 calcium binding protein A10 -0.0217972
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0213896
IFITM3 interferon induced transmembrane protein 3 -0.0213549
RPL9 ribosomal protein L9 -0.0208584
RPS11 ribosomal protein S11 -0.0208002
RPL7 ribosomal protein L7 -0.0206908
PFN1 profilin 1 -0.0202958
RRBP1 ribosome binding protein 1 -0.0201796
RPL19 ribosomal protein L19 -0.0198606
RACK1 receptor for activated C kinase 1 -0.0198057
RPL35A ribosomal protein L35a -0.0192112
RPL30 ribosomal protein L30 -0.0191738
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0190545
CALR calreticulin -0.0190313
RPL37 ribosomal protein L37 -0.0189597
HAS2 hyaluronan synthase 2 -0.0187838
CAVIN1 caveolae associated protein 1 -0.0187799
RPL38 ribosomal protein L38 -0.0185185
ZBTB38 zinc finger and BTB domain containing 38 -0.0183898
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0182506
MAP1B microtubule-associated protein 1B -0.0182208
SRGN serglycin -0.0181931
SAMD9 sterile alpha motif domain containing 9 -0.0178818
RPL23 ribosomal protein L23 -0.0173829
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0172429
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0172019
RPL15 ribosomal protein L15 -0.0171177
DUSP6 dual specificity phosphatase 6 -0.0166479