| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sildenafil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.182663 |
| C3 | complement component 3 | 0.139814 |
| FNDC3B | fibronectin type III domain containing 3B | 0.131229 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100575 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0654109 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0650022 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0649813 |
| AFDN | afadin, adherens junction formation factor | 0.0634775 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.059999 |
| JMJD1C | jumonji domain containing 1C | 0.0582562 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0555222 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0543883 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0534213 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0524725 |
| A2M | alpha-2-macroglobulin | 0.0515751 |
| RBM39 | RNA binding motif protein 39 | 0.0513832 |
| TF | transferrin | 0.0501286 |
| TXNRD1 | thioredoxin reductase 1 | 0.0495047 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0487764 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0461387 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0461369 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0454705 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0452539 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0452538 |
| GOLGA4 | golgin A4 | 0.0436589 |
| INSIG2 | insulin induced gene 2 | 0.0433825 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.042436 |
| AHSG | alpha-2-HS-glycoprotein | 0.0422883 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.041363 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0404791 |
| MYO1B | myosin IB | 0.0399323 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0394648 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0387329 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0379506 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0373884 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0373758 |
| TOP1 | topoisomerase (DNA) I | 0.0361407 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0359128 |
| DTNA | dystrobrevin, alpha | 0.0358142 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0357798 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0354333 |
| AHR | aryl hydrocarbon receptor | 0.0348935 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0344521 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0327384 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0327329 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0325801 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0325021 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0324696 |
| MRTFA | myocardin related transcription factor A | 0.0324645 |
| RPL3 | ribosomal protein L3 | 0.0324461 |
| PCBP2 | poly(rC) binding protein 2 | 0.0323577 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0323562 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0320832 |
| RTN4 | reticulon 4 | 0.0317111 |
| CRY1 | cryptochrome circadian clock 1 | 0.0306951 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0305637 |
| CCNY | cyclin Y | 0.0301682 |
| PTK2 | protein tyrosine kinase 2 | 0.0298376 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0297218 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0296522 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0296069 |
| ZNF292 | zinc finger protein 292 | 0.0296022 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0295361 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0295099 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0293361 |
| RAB6A | RAB6A, member RAS oncogene family | 0.029222 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0291107 |
| YAP1 | Yes-associated protein 1 | 0.0290495 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0287738 |
| MED13L | mediator complex subunit 13-like | 0.0286146 |
| DSTN | destrin (actin depolymerizing factor) | 0.028596 |
| VEGFA | vascular endothelial growth factor A | 0.028572 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0284113 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0283411 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0283157 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0282711 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0280894 |
| USP3 | ubiquitin specific peptidase 3 | 0.0272886 |
| LRRC1 | leucine rich repeat containing 1 | 0.0271476 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0271397 |
| MEMO1 | mediator of cell motility 1 | 0.0271252 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.027118 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0269252 |
| SNX9 | sorting nexin 9 | 0.0268818 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.026783 |
| NUP58 | nucleoporin 58 | 0.0267031 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.02654 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0263631 |
| WDR45B | WD repeat domain 45B | 0.0263085 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0262905 |
| CUL3 | cullin 3 | 0.0261083 |
| QKI | QKI, KH domain containing, RNA binding | 0.0259779 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0258845 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0258532 |
| CCNL1 | cyclin L1 | 0.0257856 |
| KIF1B | kinesin family member 1B | 0.0252922 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.025208 |
| USP47 | ubiquitin specific peptidase 47 | 0.0251957 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0251883 |
| ABI1 | abl-interactor 1 | 0.0251778 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.226501 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.196592 |
| EHBP1 | EH domain binding protein 1 | -0.149632 |
| GPC6 | glypican 6 | -0.140952 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.115502 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.11392 |
| IGF2 | insulin-like growth factor 2 | -0.101807 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.10018 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0989839 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0918479 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.081248 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0791965 |
| RPLP1 | ribosomal protein, large, P1 | -0.0781253 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0779004 |
| ATXN1 | ataxin 1 | -0.0730946 |
| FRMD5 | FERM domain containing 5 | -0.0715183 |
| ASPH | aspartate beta-hydroxylase | -0.0708791 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0700104 |
| RNF213 | ring finger protein 213 | -0.0681213 |
| FN1 | fibronectin 1 | -0.0676799 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0668797 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0635924 |
| PDLIM5 | PDZ and LIM domain 5 | -0.056474 |
| FAM107B | family with sequence similarity 107, member B | -0.0505948 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0490016 |
| TMSB10 | thymosin beta 10 | -0.0486849 |
| RPL26 | ribosomal protein L26 | -0.0484067 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0474347 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0471054 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0457695 |
| DST | dystonin | -0.0453692 |
| RIGI | RNA sensor RIG-I | -0.0442003 |
| RPL37A | ribosomal protein L37a | -0.0434239 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0432507 |
| RPS19 | ribosomal protein S19 | -0.0430338 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0430337 |
| INTS6 | integrator complex subunit 6 | -0.0428069 |
| RPS24 | ribosomal protein S24 | -0.042584 |
| VCL | vinculin | -0.0425015 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0417887 |
| PTCHD4 | patched domain containing 4 | -0.0416516 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0415766 |
| ATP10A | ATPase, class V, type 10A | -0.0414375 |
| RPL11 | ribosomal protein L11 | -0.0405641 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0405541 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0403025 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0396206 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0388651 |
| RPS27A | ribosomal protein S27a | -0.0385023 |
| FTL | ferritin, light polypeptide | -0.0381214 |
| RPLP2 | ribosomal protein, large, P2 | -0.0379106 |
| PEG3 | paternally expressed 3 | -0.0374555 |
| GK | glycerol kinase | -0.0367833 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0359075 |
| H1-0 | H1.0 linker histone | -0.0356142 |
| RPL23 | ribosomal protein L23 | -0.0341673 |
| RPS21 | ribosomal protein S21 | -0.0341138 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0340906 |
| RPL32 | ribosomal protein L32 | -0.032962 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0321602 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0320435 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0318879 |
| DSPP | dentin sialophosphoprotein | -0.0311763 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0311662 |
| ACTG1 | actin gamma 1 | -0.0311138 |
| KIAA1217 | KIAA1217 | -0.031046 |
| PLXDC2 | plexin domain containing 2 | -0.0296848 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.029097 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0288118 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0284412 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0283569 |
| RAD51B | RAD51 paralog B | -0.0280639 |
| RPS12 | ribosomal protein S12 | -0.0277905 |
| RPL38 | ribosomal protein L38 | -0.0277126 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0276758 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0275778 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0275331 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0273921 |
| HPCAL1 | hippocalcin-like 1 | -0.0271115 |
| RPL12 | ribosomal protein L12 | -0.026848 |
| MYO1E | myosin IE | -0.0264432 |
| HDAC4 | histone deacetylase 4 | -0.0264 |
| AHNAK | AHNAK nucleoprotein | -0.0261547 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0261421 |
| APOC1 | apolipoprotein C-I | -0.0258841 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.025788 |
| MT1X | metallothionein 1X | -0.0257622 |
| EGR1 | early growth response 1 | -0.0257532 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.025722 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0255905 |
| RPS6 | ribosomal protein S6 | -0.0255754 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.025531 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.025477 |
| RPL37 | ribosomal protein L37 | -0.0254541 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0253622 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0251697 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.024919 |
| TXNIP | thioredoxin interacting protein | -0.0247634 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0245132 |
| IER3 | immediate early response 3 | -0.0244019 |
