Sildenafil_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.177549
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.116093
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.106533
ANKRD11 ankyrin repeat domain 11 0.0845189
ZFAND3 zinc finger, AN1-type domain 3 0.0816033
FAM13A family with sequence similarity 13, member A 0.0798063
EREG epiregulin 0.0763673
GOLGA4 golgin A4 0.0759954
MED13L mediator complex subunit 13-like 0.0715592
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0684849
RNF145 ring finger protein 145 0.065401
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0647175
RBM39 RNA binding motif protein 39 0.063309
LMO7 LIM domain 7 0.0629951
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0592015
WAC WW domain containing adaptor with coiled-coil 0.0587782
KDM3A lysine (K)-specific demethylase 3A 0.0579958
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0564011
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0512304
OGA O-GlcNAcase 0.0505285
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0502413
DSCAM Down syndrome cell adhesion molecule 0.0485585
RAB1A RAB1A, member RAS oncogene family 0.0481125
ZNF292 zinc finger protein 292 0.0479843
PUM2 pumilio RNA-binding family member 2 0.0469117
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0465454
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0462994
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0461899
RNF43 ring finger protein 43 0.0457782
KDM6A lysine (K)-specific demethylase 6A 0.0453941
UBE2H ubiquitin-conjugating enzyme E2H 0.0447562
FNDC3B fibronectin type III domain containing 3B 0.0443787
FAT1 FAT atypical cadherin 1 0.0441225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0440136
NDRG1 N-myc downstream regulated 1 0.0439606
SEC31A SEC31 homolog A (S. cerevisiae) 0.0439422
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0438263
STRN3 striatin, calmodulin binding protein 3 0.043672
TFG TRK-fused gene 0.0431903
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0430703
COG5 component of oligomeric golgi complex 5 0.0429371
MBNL2 muscleblind-like splicing regulator 2 0.0428335
MARCHF6 membrane associated ring-CH-type finger 6 0.041948
EPS8 epidermal growth factor receptor pathway substrate 8 0.0412777
GARS1 glycyl-tRNA synthetase 1 0.0411907
CCNY cyclin Y 0.0409872
USP3 ubiquitin specific peptidase 3 0.0408628
TPD52 tumor protein D52 0.0406922
KMT2E lysine (K)-specific methyltransferase 2E 0.0406275
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0405775
EZR ezrin 0.0402265
GSK3B glycogen synthase kinase 3 beta 0.0399773
NUP58 nucleoporin 58 0.0398394
IARS1 isoleucyl-tRNA synthetase 1 0.0396637
ZFC3H1 zinc finger, C3H1-type containing 0.0396528
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0393824
MACF1 microtubule-actin crosslinking factor 1 0.0392117
NAMPT nicotinamide phosphoribosyltransferase 0.0390619
SPAG9 sperm associated antigen 9 0.0387006
HELZ helicase with zinc finger 0.038308
TXNRD1 thioredoxin reductase 1 0.0382429
MON2 MON2 homolog (S. cerevisiae) 0.0379471
UBA6 ubiquitin-like modifier activating enzyme 6 0.0378583
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0375747
ESYT2 extended synaptotagmin-like protein 2 0.0375584
TRIM2 tripartite motif containing 2 0.0373671
ITGA6 integrin, alpha 6 0.0370897
SETD5 SET domain containing 5 0.0368312
NEK7 NIMA-related kinase 7 0.0367705
SHROOM3 shroom family member 3 0.0365247
BIRC6 baculoviral IAP repeat containing 6 0.0362654
RREB1 ras responsive element binding protein 1 0.036185
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0361483
ESRP1 epithelial splicing regulatory protein 1 0.0354692
BTBD9 BTB (POZ) domain containing 9 0.0352926
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0346211
COPA coatomer protein complex, subunit alpha 0.0343464
TXNIP thioredoxin interacting protein 0.034121
KDM7A lysine (K)-specific demethylase 7A 0.0340216
TM9SF3 transmembrane 9 superfamily member 3 0.0340111
NCOR1 nuclear receptor corepressor 1 0.0339872
PTBP3 polypyrimidine tract binding protein 3 0.0338651
NCKAP1 NCK-associated protein 1 0.0338511
PUM1 pumilio RNA-binding family member 1 0.0338425
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0337977
WDR45B WD repeat domain 45B 0.0337425
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0337136
EWSR1 EWS RNA-binding protein 1 0.0337104
USP6NL USP6 N-terminal like 0.0333375
SUCO SUN domain containing ossification factor 0.0332962
YME1L1 YME1-like 1 ATPase 0.0331416
MATR3 matrin 3 0.0326734
JMJD1C jumonji domain containing 1C 0.0325773
DERA deoxyribose-phosphate aldolase (putative) 0.0325347
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0324367
FNBP1L formin binding protein 1-like 0.0324261
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0322928
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0322441
ANKRD17 ankyrin repeat domain 17 0.032214
ANXA2 annexin A2 0.0321412

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.1643
TMSB10 thymosin beta 10 -0.153389
PTMA prothymosin, alpha -0.107324
RPS6 ribosomal protein S6 -0.0893037
TPT1 tumor protein, translationally-controlled 1 -0.0879367
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0677255
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.067631
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0634304
RPS19 ribosomal protein S19 -0.0626526
NALF1 NALCN channel auxiliary factor 1 -0.0618159
RPS8 ribosomal protein S8 -0.0613117
ACTG1 actin gamma 1 -0.0583675
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0580651
VCL vinculin -0.056316
RPLP2 ribosomal protein, large, P2 -0.0534515
RPS12 ribosomal protein S12 -0.0526703
RPL35A ribosomal protein L35a -0.0523801
ONECUT3 one cut homeobox 3 -0.0515037
RPL34 ribosomal protein L34 -0.050746
RPLP1 ribosomal protein, large, P1 -0.0485691
RPL37A ribosomal protein L37a -0.0469338
RPL9 ribosomal protein L9 -0.0431028
RPL26 ribosomal protein L26 -0.0427432
RPL31 ribosomal protein L31 -0.04218
RPL12 ribosomal protein L12 -0.041741
RPL36 ribosomal protein L36 -0.0416663
SLC35F3 solute carrier family 35, member F3 -0.0406184
RPL23 ribosomal protein L23 -0.040475
FTL ferritin, light polypeptide -0.040439
GREB1L growth regulation by estrogen in breast cancer-like -0.0392213
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0391172
RPS3 ribosomal protein S3 -0.0390176
LAMA4 laminin, alpha 4 -0.0386483
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0383329
PTPRK protein tyrosine phosphatase, receptor type, K -0.0382998
RNF217 ring finger protein 217 -0.0368149
FHIT fragile histidine triad -0.0359238
RPS29 ribosomal protein S29 -0.0355727
S100P S100 calcium binding protein P -0.0341397
ALCAM activated leukocyte cell adhesion molecule -0.0340468
S100A6 S100 calcium binding protein A6 -0.0335617
RPS27A ribosomal protein S27a -0.0334558
MT2A metallothionein 2A -0.0323989
EGFR epidermal growth factor receptor -0.0319189
RPL11 ribosomal protein L11 -0.0311208
PSD3 pleckstrin and Sec7 domain containing 3 -0.0310964
RPL19 ribosomal protein L19 -0.0310417
ANTXR2 anthrax toxin receptor 2 -0.0304312
RPS17 ribosomal protein S17 -0.029866
RPS27 ribosomal protein S27 -0.0296168
RPS23 ribosomal protein S23 -0.0293661
RPL8 ribosomal protein L8 -0.0293521
PTPRB protein tyrosine phosphatase, receptor type, B -0.0293135
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.028028
RPS21 ribosomal protein S21 -0.0280032
RPS24 ribosomal protein S24 -0.0275984
S100A10 S100 calcium binding protein A10 -0.0268716
RPL7A ribosomal protein L7a -0.0266917
S100A9 S100 calcium binding protein A9 -0.0266259
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0266124
RPL18 ribosomal protein L18 -0.0258908
RPS11 ribosomal protein S11 -0.025535
MYO1E myosin IE -0.0253942
RPL28 ribosomal protein L28 -0.0250929
KRT18 keratin 18, type I -0.0250489
RPS13 ribosomal protein S13 -0.0250452
POTEF POTE ankyrin domain family, member F -0.0246493
RAD51B RAD51 paralog B -0.0238852
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.023674
RPS10 ribosomal protein S10 -0.0236503
RPS16 ribosomal protein S16 -0.023589
RPL32 ribosomal protein L32 -0.0235795
RPS25 ribosomal protein S25 -0.0232361
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0232324
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0231516
RPS14 ribosomal protein S14 -0.0231194
RPL13A ribosomal protein L13a -0.0229598
HMGA1 high mobility group AT-hook 1 -0.0225485
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0223387
RPL37 ribosomal protein L37 -0.0222774
RPL35 ribosomal protein L35 -0.0221295
PDE4D phosphodiesterase 4D, cAMP-specific -0.0220482
RPL5 ribosomal protein L5 -0.0219952
MAML3 mastermind-like 3 (Drosophila) -0.0219481
ZBTB20 zinc finger and BTB domain containing 20 -0.0219446
IER3 immediate early response 3 -0.0218266
RPL27 ribosomal protein L27 -0.0217326
F3 coagulation factor III (thromboplastin, tissue factor) -0.021282
ASPH aspartate beta-hydroxylase -0.0211056
MT1X metallothionein 1X -0.0208198
SVIL supervillin -0.0205409
PDLIM5 PDZ and LIM domain 5 -0.0205011
TFF3 trefoil factor 3 (intestinal) -0.0203882
POF1B premature ovarian failure, 1B -0.0201708
RPLP0 ribosomal protein, large, P0 -0.0199245
RPL36A ribosomal protein L36a -0.019407
RPS15 ribosomal protein S15 -0.0192942
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0191416
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0190954
KRT19 keratin 19, type I -0.019