| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sildenafil_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.127532 |
| TP63 | tumor protein p63 | 0.11641 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.107052 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.104259 |
| CD44 | CD44 molecule (Indian blood group) | 0.0951916 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0922185 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0888357 |
| FMNL2 | formin-like 2 | 0.0821474 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0802805 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0784396 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0768078 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0744659 |
| EFNA5 | ephrin-A5 | 0.0710798 |
| EHBP1 | EH domain binding protein 1 | 0.06989 |
| CADM2 | cell adhesion molecule 2 | 0.0658617 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0614209 |
| TSC22D1 | TSC22 domain family, member 1 | 0.060952 |
| TNS3 | tensin 3 | 0.057936 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0577819 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0558023 |
| EPHA4 | EPH receptor A4 | 0.0528719 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0520878 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0513624 |
| RUNX1 | runt-related transcription factor 1 | 0.0506279 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0496215 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0486529 |
| RAD51B | RAD51 paralog B | 0.0480568 |
| CMIP | c-Maf inducing protein | 0.046767 |
| DNER | delta/notch-like EGF repeat containing | 0.0436322 |
| EXOC4 | exocyst complex component 4 | 0.0434163 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0428882 |
| APP | amyloid beta (A4) precursor protein | 0.0428306 |
| PDE10A | phosphodiesterase 10A | 0.0424776 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0417889 |
| HDAC9 | histone deacetylase 9 | 0.0416326 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0412212 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0408037 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0391003 |
| PTK2 | protein tyrosine kinase 2 | 0.0380482 |
| RNF213 | ring finger protein 213 | 0.0373652 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0370733 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0368784 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.035421 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0353635 |
| DENND1A | DENN/MADD domain containing 1A | 0.0343382 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0340754 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0330752 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0329372 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0329302 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0318233 |
| RIGI | RNA sensor RIG-I | 0.0311818 |
| FNIP1 | folliculin interacting protein 1 | 0.0309592 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0308219 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0291433 |
| PLK2 | polo-like kinase 2 | 0.0283275 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0282417 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0280907 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0279329 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0273074 |
| SP100 | SP100 nuclear antigen | 0.0266742 |
| MYOF | myoferlin | 0.026498 |
| YEATS2 | YEATS domain containing 2 | 0.0262369 |
| PRELID2 | PRELI domain containing 2 | 0.0257317 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0256328 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0255672 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.025276 |
| EGFR | epidermal growth factor receptor | 0.0250323 |
| RASAL2 | RAS protein activator like 2 | 0.024963 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0248021 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0246549 |
| COL5A2 | collagen, type V, alpha 2 | 0.0241655 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.023831 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0233047 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0231967 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0230006 |
| SMYD3 | SET and MYND domain containing 3 | 0.0226711 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.022447 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0222293 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0221497 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0210764 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0209555 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0207913 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0207268 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0205788 |
| AEBP2 | AE binding protein 2 | 0.0205512 |
| CUX1 | cut-like homeobox 1 | 0.0204545 |
| WDR27 | WD repeat domain 27 | 0.0204426 |
| LYST | lysosomal trafficking regulator | 0.0202984 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0200408 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0199276 |
| PDGFC | platelet derived growth factor C | 0.0197615 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0196585 |
| CDK6 | cyclin-dependent kinase 6 | 0.01958 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0195651 |
| NAV2 | neuron navigator 2 | 0.0194016 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0193965 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0193414 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0192733 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0191753 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.019147 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.399436 |
| VIM | vimentin | -0.244017 |
| MT2A | metallothionein 2A | -0.176582 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139629 |
| TMSB10 | thymosin beta 10 | -0.123243 |
| LOC112694756 | uncharaterized LOC112694756 | -0.081102 |
| ACTG1 | actin gamma 1 | -0.0628368 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0577754 |
| TXNRD1 | thioredoxin reductase 1 | -0.0561265 |
| TMSB4X | thymosin beta 4, X-linked | -0.0552101 |
| RPL35A | ribosomal protein L35a | -0.0537329 |
| MT1E | metallothionein 1E | -0.0511558 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0507975 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0475239 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0472138 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0437755 |
| RPL23 | ribosomal protein L23 | -0.0434497 |
| FTL | ferritin, light polypeptide | -0.0412504 |
| RPS8 | ribosomal protein S8 | -0.0397902 |
| MT1X | metallothionein 1X | -0.0396721 |
| TMEM41B | transmembrane protein 41B | -0.0395511 |
| EGR1 | early growth response 1 | -0.038202 |
| KLF6 | Kruppel-like factor 6 | -0.0375282 |
| SPAG9 | sperm associated antigen 9 | -0.0361205 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0335254 |
| RTN4 | reticulon 4 | -0.0329627 |
| RPLP0 | ribosomal protein, large, P0 | -0.032545 |
| RPLP1 | ribosomal protein, large, P1 | -0.0316863 |
| S100A6 | S100 calcium binding protein A6 | -0.0304474 |
| RPL26 | ribosomal protein L26 | -0.0282491 |
| RPS4X | ribosomal protein S4, X-linked | -0.0280509 |
| RACK1 | receptor for activated C kinase 1 | -0.0273728 |
| SRGN | serglycin | -0.0268101 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0265381 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0264239 |
| EMP1 | epithelial membrane protein 1 | -0.0260085 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0259836 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0259192 |
| RPS24 | ribosomal protein S24 | -0.0254629 |
| UBC | ubiquitin C | -0.0254578 |
| RPL5 | ribosomal protein L5 | -0.0254059 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0253952 |
| RPL12 | ribosomal protein L12 | -0.0252554 |
| WDR45B | WD repeat domain 45B | -0.0252237 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0249631 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0249432 |
| YBX1 | Y box binding protein 1 | -0.0245648 |
| LDHA | lactate dehydrogenase A | -0.0239632 |
| PTMA | prothymosin, alpha | -0.0228248 |
| HMGA1 | high mobility group AT-hook 1 | -0.0225132 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0222366 |
| RPL34 | ribosomal protein L34 | -0.0219069 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0217516 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.021587 |
| GNAS | GNAS complex locus | -0.021454 |
| ARF1 | ADP-ribosylation factor 1 | -0.0213644 |
| S100A10 | S100 calcium binding protein A10 | -0.0213025 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0210704 |
| TNPO1 | transportin 1 | -0.0210249 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0209594 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0209212 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.020869 |
| RPS20 | ribosomal protein S20 | -0.0202154 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0201901 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0200104 |
| POTEF | POTE ankyrin domain family, member F | -0.0199366 |
| RPS2 | ribosomal protein S2 | -0.0198603 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0197211 |
| RPL28 | ribosomal protein L28 | -0.019684 |
| PYGB | phosphorylase, glycogen; brain | -0.0196246 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0188416 |
| OLA1 | Obg-like ATPase 1 | -0.0187887 |
| ERCC1 | excision repair cross-complementation group 1 | -0.0186106 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0185453 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.018539 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.018466 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0182016 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0181844 |
| RPS27A | ribosomal protein S27a | -0.0181601 |
| RPL8 | ribosomal protein L8 | -0.0180157 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | -0.0179391 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0178416 |
| RPS6 | ribosomal protein S6 | -0.0177654 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0173848 |
| RPS19 | ribosomal protein S19 | -0.0173841 |
| ETNK1 | ethanolamine kinase 1 | -0.0171166 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0170939 |
| RPL32 | ribosomal protein L32 | -0.0170575 |
| NUP58 | nucleoporin 58 | -0.0170313 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0170262 |
| JUN | jun proto-oncogene | -0.0168113 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0165339 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0164618 |
| RPS28 | ribosomal protein S28 | -0.0164413 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0162837 |
| YBX3 | Y box binding protein 3 | -0.0161734 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0160527 |
| RPL35 | ribosomal protein L35 | -0.0159559 |
| RPL9 | ribosomal protein L9 | -0.0159486 |
| RPL18 | ribosomal protein L18 | -0.015916 |
