Sildenafil_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0967137
TBC1D22A TBC1 domain family, member 22A 0.0751637
FAM13A family with sequence similarity 13, member A 0.0613587
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0595491
EGFR epidermal growth factor receptor 0.053334
GCLC glutamate-cysteine ligase, catalytic subunit 0.0493404
NAMPT nicotinamide phosphoribosyltransferase 0.0480577
RUNX1 runt-related transcription factor 1 0.0475652
SMAD3 SMAD family member 3 0.0466091
CES1 carboxylesterase 1 0.0439532
CAMTA1 calmodulin binding transcription activator 1 0.0432318
SOD2 superoxide dismutase 2, mitochondrial 0.043044
NGLY1 N-glycanase 1 0.0429157
AGO2 argonaute RISC catalytic component 2 0.0404975
ZC3H11A zinc finger CCCH-type containing 11A 0.0366518
ARRDC3 arrestin domain containing 3 0.0336725
ANKRD10 ankyrin repeat domain 10 0.0323782
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0312726
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0309269
PLEC plectin 0.0308366
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0304673
OGA O-GlcNAcase 0.0296439
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296335
GLS2 glutaminase 2 (liver, mitochondrial) 0.0291895
FNIP1 folliculin interacting protein 1 0.0288254
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0285993
YEATS2 YEATS domain containing 2 0.0279752
TMEM165 transmembrane protein 165 0.0279553
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0277166
NDE1 nudE neurodevelopment protein 1 0.0277058
FTH1 ferritin, heavy polypeptide 1 0.027178
HOOK2 hook microtubule-tethering protein 2 0.0266347
USP34 ubiquitin specific peptidase 34 0.0265924
KIAA1217 KIAA1217 0.0265664
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0264083
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0263584
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257678
RICTOR RPTOR independent companion of MTOR, complex 2 0.025153
ANO6 anoctamin 6 0.0251489
MYH9 myosin, heavy chain 9, non-muscle 0.02512
ATP13A3 ATPase type 13A3 0.0241995
ZNF292 zinc finger protein 292 0.0234938
MKI67 marker of proliferation Ki-67 0.0232277
MYO1B myosin IB 0.0232132
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0231415
SUCO SUN domain containing ossification factor 0.0228994
USP9X ubiquitin specific peptidase 9, X-linked 0.0226961
CEMIP cell migration inducing protein, hyaluronan binding 0.0225704
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0224038
UBE2O ubiquitin-conjugating enzyme E2O 0.0221836
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0216805
DTNA dystrobrevin, alpha 0.0213088
HELZ helicase with zinc finger 0.0212075
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0211825
KCMF1 potassium channel modulatory factor 1 0.0208538
ZFC3H1 zinc finger, C3H1-type containing 0.0205313
CYLD cylindromatosis (turban tumor syndrome) 0.0203715
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0198617
TPD52 tumor protein D52 0.0198118
EP300 E1A binding protein p300 0.0197622
TAOK1 TAO kinase 1 0.0197426
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0196705
BRWD3 bromodomain and WD repeat domain containing 3 0.0195174
SLTM SAFB-like, transcription modulator 0.0193364
MARF1 meiosis regulator and mRNA stability factor 1 0.018861
PRELID2 PRELI domain containing 2 0.0184406
PUM2 pumilio RNA-binding family member 2 0.0184277
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0183607
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0182068
ABLIM1 actin binding LIM protein 1 0.0181407
GPATCH2L G patch domain containing 2-like 0.0179663
SEC31A SEC31 homolog A (S. cerevisiae) 0.0178499
SPAG9 sperm associated antigen 9 0.0175365
UBA6 ubiquitin-like modifier activating enzyme 6 0.0174083
BIRC3 baculoviral IAP repeat containing 3 0.0173778
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0170896
BRWD1 bromodomain and WD repeat domain containing 1 0.0165391
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0165307
FAT1 FAT atypical cadherin 1 0.0165174
GNPDA1 glucosamine-6-phosphate deaminase 1 0.016267
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0161097
PAPOLA poly(A) polymerase alpha 0.0161045
NPTN neuroplastin 0.0160895
STRN3 striatin, calmodulin binding protein 3 0.0158968
ZNF638 zinc finger protein 638 0.0157652
TMCO3 transmembrane and coiled-coil domains 3 0.0157582
AFF1 AF4/FMR2 family, member 1 0.015615
RNF169 ring finger protein 169 0.0155567
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0154735
RLIM ring finger protein, LIM domain interacting 0.0152877
SHB Src homology 2 domain containing adaptor protein B 0.0151163
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.014823
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0146543
KDM6A lysine (K)-specific demethylase 6A 0.0146162
EIF4B eukaryotic translation initiation factor 4B 0.0143863
DENND4A DENN/MADD domain containing 4A 0.0143765
KLC1 kinesin light chain 1 0.0143703
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0143672
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0143566
NF1 neurofibromin 1 0.0141584

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.423344
TMSB10 thymosin beta 10 -0.20788
MT2A metallothionein 2A -0.138914
FTL ferritin, light polypeptide -0.0804591
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0793396
TPT1 tumor protein, translationally-controlled 1 -0.0789902
ACTG1 actin gamma 1 -0.0787374
S100A10 S100 calcium binding protein A10 -0.0741979
THSD4 thrombospondin, type I, domain containing 4 -0.0729093
SEC61G Sec61 gamma subunit -0.0660877
EGR1 early growth response 1 -0.0631801
PKM pyruvate kinase, muscle -0.0599147
RPLP1 ribosomal protein, large, P1 -0.0598583
RPL35A ribosomal protein L35a -0.0589167
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0588704
RPS3 ribosomal protein S3 -0.0554023
CST3 cystatin C -0.0524514
PTMA prothymosin, alpha -0.0513454
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0503739
RPS25 ribosomal protein S25 -0.0489888
CAV1 caveolin 1, caveolae protein, 22kDa -0.048885
PDLIM5 PDZ and LIM domain 5 -0.0480156
LOC112694756 uncharaterized LOC112694756 -0.0463222
LDHA lactate dehydrogenase A -0.0457771
ASPH aspartate beta-hydroxylase -0.0446663
RPS6 ribosomal protein S6 -0.0436824
AREG amphiregulin -0.0428849
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0428609
RPL37A ribosomal protein L37a -0.0424522
RPS8 ribosomal protein S8 -0.0417581
RPL31 ribosomal protein L31 -0.0409969
PTPRM protein tyrosine phosphatase, receptor type, M -0.0404029
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0399603
RPS12 ribosomal protein S12 -0.0388209
LAMC2 laminin, gamma 2 -0.0387573
B2M beta-2-microglobulin -0.0384094
KRT7 keratin 7, type II -0.03825
ENO1 enolase 1, (alpha) -0.0381991
EIF1 eukaryotic translation initiation factor 1 -0.0366185
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0362628
RPS24 ribosomal protein S24 -0.0362494
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0361807
IFI6 interferon, alpha-inducible protein 6 -0.0350821
RPL34 ribosomal protein L34 -0.0345574
RPL12 ribosomal protein L12 -0.0343839
MT1X metallothionein 1X -0.0341636
S100A9 S100 calcium binding protein A9 -0.0340558
PDE4D phosphodiesterase 4D, cAMP-specific -0.0333274
RPS27A ribosomal protein S27a -0.0327868
IGFBP5 insulin-like growth factor binding protein 5 -0.0327526
ANXA2 annexin A2 -0.0322445
LAMA4 laminin, alpha 4 -0.032142
KRT18 keratin 18, type I -0.0318239
RPLP0 ribosomal protein, large, P0 -0.0312143
RPL11 ribosomal protein L11 -0.0311522
INTS6 integrator complex subunit 6 -0.0309427
S100A11 S100 calcium binding protein A11 -0.0304034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0301657
CAV2 caveolin 2 -0.0299955
POTEF POTE ankyrin domain family, member F -0.0299691
S100P S100 calcium binding protein P -0.0295611
RPL23 ribosomal protein L23 -0.0285573
VCL vinculin -0.028335
MYOF myoferlin -0.0281249
RPLP2 ribosomal protein, large, P2 -0.0277807
RPL19 ribosomal protein L19 -0.0276026
RPS23 ribosomal protein S23 -0.0272609
S100A6 S100 calcium binding protein A6 -0.0272343
SLC38A1 solute carrier family 38, member 1 -0.0271426
RPS19 ribosomal protein S19 -0.0270221
TPM4 tropomyosin 4 -0.0269484
CCND1 cyclin D1 -0.026497
HMGA1 high mobility group AT-hook 1 -0.0263726
RPL36 ribosomal protein L36 -0.0263335
RPS29 ribosomal protein S29 -0.0260212
OSMR oncostatin M receptor -0.0258384
RPL37 ribosomal protein L37 -0.0258161
RPL30 ribosomal protein L30 -0.0257743
RPS27 ribosomal protein S27 -0.0255567
CPE carboxypeptidase E -0.0251942
RPS21 ribosomal protein S21 -0.0250506
RPS17 ribosomal protein S17 -0.0248241
RPS14 ribosomal protein S14 -0.0246993
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0245186
IER3 immediate early response 3 -0.0243537
NSUN6 NOP2/Sun domain family, member 6 -0.0243329
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.024127
RPL8 ribosomal protein L8 -0.0240839
WSB1 WD repeat and SOCS box containing 1 -0.0237891
LOC102724023 ES1 protein homolog, mitochondrial -0.0237875
TPI1 triosephosphate isomerase 1 -0.0237338
LPP LIM domain containing preferred translocation partner in lipoma -0.023677
LMO7 LIM domain 7 -0.0231731
SCEL sciellin -0.023132
HLA-B major histocompatibility complex, class I, B -0.0229572
SLC38A2 solute carrier family 38, member 2 -0.0229469
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0227572
AKAP12 A kinase (PRKA) anchor protein 12 -0.022033
IGFBP3 insulin-like growth factor binding protein 3 -0.0219613
ZSWIM6 zinc finger, SWIM-type containing 6 -0.021879