| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sildenafil_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.161445 |
| GRB10 | growth factor receptor-bound protein 10 | 0.154303 |
| USP34 | ubiquitin specific peptidase 34 | 0.139943 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.139802 |
| CDH13 | cadherin 13 | 0.130384 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.121453 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.114766 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.109603 |
| FN1 | fibronectin 1 | 0.0965228 |
| NAV2 | neuron navigator 2 | 0.0950623 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0884411 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0871172 |
| FAM13A | family with sequence similarity 13, member A | 0.0822985 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0769591 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0765969 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0705646 |
| MTSS1 | metastasis suppressor 1 | 0.065947 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0651756 |
| PCBP2 | poly(rC) binding protein 2 | 0.0647452 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.06453 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0635273 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0607324 |
| DST | dystonin | 0.0597748 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0592597 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0579429 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0577628 |
| PRELID2 | PRELI domain containing 2 | 0.0574198 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0549425 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0540806 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0539282 |
| SEPTIN9 | septin 9 | 0.052866 |
| ATXN1 | ataxin 1 | 0.0515679 |
| PTK2 | protein tyrosine kinase 2 | 0.0488702 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0479838 |
| EFNA5 | ephrin-A5 | 0.0477974 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0472305 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0463275 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0456782 |
| HMGA2 | high mobility group AT-hook 2 | 0.0433169 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0429238 |
| RUNX1 | runt-related transcription factor 1 | 0.0420368 |
| PRKCA | protein kinase C, alpha | 0.0419042 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0415586 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0412535 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0411826 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0411003 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0408003 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0403058 |
| FLNB | filamin B, beta | 0.0394501 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0394232 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0388145 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0384111 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0384079 |
| OXR1 | oxidation resistance 1 | 0.0383408 |
| MEF2A | myocyte enhancer factor 2A | 0.0380003 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0379032 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0371982 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0370959 |
| DIAPH2 | diaphanous-related formin 2 | 0.0368043 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0365766 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0365637 |
| SIK3 | SIK family kinase 3 | 0.0362141 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0359401 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0357482 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0352692 |
| RAI14 | retinoic acid induced 14 | 0.0348599 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | 0.0344984 |
| LOXL2 | lysyl oxidase-like 2 | 0.0342089 |
| DOCK5 | dedicator of cytokinesis 5 | 0.034149 |
| CEP250 | centrosomal protein 250kDa | 0.0336439 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0333634 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0333587 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.033051 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0329588 |
| NHSL1 | NHS-like 1 | 0.0329455 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0328982 |
| CTNNBL1 | catenin, beta like 1 | 0.0328671 |
| CCNY | cyclin Y | 0.0328576 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.032611 |
| JMJD1C | jumonji domain containing 1C | 0.0323829 |
| HDAC9 | histone deacetylase 9 | 0.0323259 |
| NAV1 | neuron navigator 1 | 0.0322394 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0319709 |
| FNIP1 | folliculin interacting protein 1 | 0.0315676 |
| FBN1 | fibrillin 1 | 0.031517 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0314953 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0314785 |
| NBAS | neuroblastoma amplified sequence | 0.0311194 |
| DENND1A | DENN/MADD domain containing 1A | 0.0309102 |
| FMNL2 | formin-like 2 | 0.0306805 |
| EHBP1 | EH domain binding protein 1 | 0.030562 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0303429 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0301688 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.030014 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0296507 |
| MYO1B | myosin IB | 0.0294667 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0292968 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0292193 |
| VEGFC | vascular endothelial growth factor C | 0.0290498 |
| MCL1 | myeloid cell leukemia 1 | 0.0289261 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16893 |
| TMSB10 | thymosin beta 10 | -0.127286 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111581 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0844099 |
| FTL | ferritin, light polypeptide | -0.0836862 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0696352 |
| CD44 | CD44 molecule (Indian blood group) | -0.0678415 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0669015 |
| MT2A | metallothionein 2A | -0.0591479 |
| RPLP1 | ribosomal protein, large, P1 | -0.0584481 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.054608 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0456066 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0438718 |
| LMAN1 | lectin, mannose-binding, 1 | -0.042676 |
| RPL23 | ribosomal protein L23 | -0.0426395 |
| IER3 | immediate early response 3 | -0.0397671 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0396122 |
| RPL35A | ribosomal protein L35a | -0.039126 |
| RPS19 | ribosomal protein S19 | -0.0382516 |
| RPL36 | ribosomal protein L36 | -0.0381713 |
| RPS24 | ribosomal protein S24 | -0.0362894 |
| OSMR | oncostatin M receptor | -0.0346419 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0334784 |
| NPC1 | Niemann-Pick disease, type C1 | -0.031566 |
| RPL32 | ribosomal protein L32 | -0.0312971 |
| RPL12 | ribosomal protein L12 | -0.0312786 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0309842 |
| RPS21 | ribosomal protein S21 | -0.0309192 |
| KYNU | kynureninase | -0.0299205 |
| GLCCI1 | glucocorticoid induced 1 | -0.0288943 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0287401 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0282574 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0277128 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0276364 |
| RACK1 | receptor for activated C kinase 1 | -0.0275553 |
| RPL34 | ribosomal protein L34 | -0.0274857 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0265723 |
| NTN4 | netrin 4 | -0.0265355 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0264298 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0263268 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0263259 |
| PTMA | prothymosin, alpha | -0.0260252 |
| GNAS | GNAS complex locus | -0.0256473 |
| RPS6 | ribosomal protein S6 | -0.0243183 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0240807 |
| WDR45B | WD repeat domain 45B | -0.0237368 |
| RPL28 | ribosomal protein L28 | -0.0235724 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0234398 |
| HLA-B | major histocompatibility complex, class I, B | -0.0233295 |
| B2M | beta-2-microglobulin | -0.0230681 |
| RPS29 | ribosomal protein S29 | -0.0228807 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.022786 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0226737 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0224335 |
| RPLP2 | ribosomal protein, large, P2 | -0.0222081 |
| RPLP0 | ribosomal protein, large, P0 | -0.021847 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0211525 |
| TNNC1 | troponin C type 1 (slow) | -0.0211023 |
| RPL38 | ribosomal protein L38 | -0.0209648 |
| RPL9 | ribosomal protein L9 | -0.0209409 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0207766 |
| RPS16 | ribosomal protein S16 | -0.0207635 |
| CCNI | cyclin I | -0.0203123 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0202573 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0200471 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0200036 |
| VIM | vimentin | -0.0198934 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0196411 |
| TXNRD1 | thioredoxin reductase 1 | -0.0192167 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0191792 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0190602 |
| EGR1 | early growth response 1 | -0.0190402 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0190031 |
| RPS8 | ribosomal protein S8 | -0.0189634 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0188554 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0188075 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0183975 |
| RPS25 | ribosomal protein S25 | -0.0183293 |
| S100A9 | S100 calcium binding protein A9 | -0.018116 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0180686 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0180659 |
| GLG1 | golgi glycoprotein 1 | -0.017923 |
| RPL11 | ribosomal protein L11 | -0.0175558 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0175429 |
| RPL27A | ribosomal protein L27a | -0.0175277 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0174286 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.017298 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0172666 |
| RPL37A | ribosomal protein L37a | -0.0172053 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0170442 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0170083 |
| SRGN | serglycin | -0.0169962 |
| LOX | lysyl oxidase | -0.0169948 |
| RPL26 | ribosomal protein L26 | -0.0169266 |
| RPL31 | ribosomal protein L31 | -0.016865 |
| CANX | calnexin | -0.016719 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0166622 |
| RPS13 | ribosomal protein S13 | -0.016527 |
| RPL19 | ribosomal protein L19 | -0.0164644 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0161787 |
