Sildenafil_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.139858
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0976268
ZFAND3 zinc finger, AN1-type domain 3 0.095927
SAMD4A sterile alpha motif domain containing 4A 0.0948592
TPM3 tropomyosin 3 0.0896327
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0889862
FMNL2 formin-like 2 0.0834757
MACF1 microtubule-actin crosslinking factor 1 0.0828756
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0828679
KTN1 kinectin 1 (kinesin receptor) 0.0810912
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.07552
TRIO trio Rho guanine nucleotide exchange factor 0.0752376
FNDC3B fibronectin type III domain containing 3B 0.0717879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0656936
USP3 ubiquitin specific peptidase 3 0.0652522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0621761
APP amyloid beta (A4) precursor protein 0.0611892
WDR43 WD repeat domain 43 0.059619
PUM2 pumilio RNA-binding family member 2 0.0588651
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0586608
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0576712
MATR3 matrin 3 0.0576423
UBASH3B ubiquitin associated and SH3 domain containing B 0.0574557
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0572203
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0567093
KMT2E lysine (K)-specific methyltransferase 2E 0.0557626
PTK2 protein tyrosine kinase 2 0.0556238
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0552066
PARD3 par-3 family cell polarity regulator 0.0548254
TPD52 tumor protein D52 0.0543551
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0543267
CMIP c-Maf inducing protein 0.0538897
BCLAF1 BCL2-associated transcription factor 1 0.0531264
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0521866
FAM168A family with sequence similarity 168, member A 0.0514557
RBM25 RNA binding motif protein 25 0.0497189
BIRC6 baculoviral IAP repeat containing 6 0.0486042
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.04719
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0468307
AKAP13 A kinase (PRKA) anchor protein 13 0.0467065
KDM3A lysine (K)-specific demethylase 3A 0.0455352
CALR calreticulin 0.0453184
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0452891
DOCK4 dedicator of cytokinesis 4 0.0452584
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0450362
MYOF myoferlin 0.0446816
FXR1 fragile X mental retardation, autosomal homolog 1 0.0446098
PYGL phosphorylase, glycogen, liver 0.0444446
RNF145 ring finger protein 145 0.0431984
RBM39 RNA binding motif protein 39 0.0430803
ANKRD11 ankyrin repeat domain 11 0.0424406
PUM1 pumilio RNA-binding family member 1 0.042319
WAC WW domain containing adaptor with coiled-coil 0.0421465
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0413348
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0412004
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0407858
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.040412
YBX3 Y box binding protein 3 0.0402689
JAK1 Janus kinase 1 0.039999
ERBIN erbb2 interacting protein 0.0393275
TLK1 tousled-like kinase 1 0.0391746
VIM vimentin 0.0387763
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.038666
DOCK5 dedicator of cytokinesis 5 0.0382649
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.038036
GLS2 glutaminase 2 (liver, mitochondrial) 0.0378663
TFG TRK-fused gene 0.0372712
RAB1A RAB1A, member RAS oncogene family 0.0372248
FOXO3 forkhead box O3 0.0369153
TRA2A transformer 2 alpha homolog (Drosophila) 0.0368865
ADAM9 ADAM metallopeptidase domain 9 0.0368117
RSRC2 arginine/serine-rich coiled-coil 2 0.0366669
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0362201
RICTOR RPTOR independent companion of MTOR, complex 2 0.0354698
ZNF292 zinc finger protein 292 0.0353531
CAMTA1 calmodulin binding transcription activator 1 0.035249
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0352045
IGFBP3 insulin-like growth factor binding protein 3 0.0347485
HDGF hepatoma-derived growth factor 0.0347062
PAWR PRKC, apoptosis, WT1, regulator 0.0346137
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0345997
RTN4 reticulon 4 0.034305
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0339758
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0337298
TRA2B transformer 2 beta homolog (Drosophila) 0.0334552
KIF5B kinesin family member 5B 0.0325078
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0324235
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323393
NAMPT nicotinamide phosphoribosyltransferase 0.0322838
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0321682
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0320931
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0319428
SFTPA2 surfactant protein A2 0.0319329
IQGAP1 IQ motif containing GTPase activating protein 1 0.0318002
ADAM17 ADAM metallopeptidase domain 17 0.03178
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316598
YAP1 Yes-associated protein 1 0.0315123
RBM33 RNA binding motif protein 33 0.0313723
LPP LIM domain containing preferred translocation partner in lipoma 0.0311904

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.186545
FTL ferritin, light polypeptide -0.16991
PM20D1 peptidase M20 domain containing 1 -0.140133
TXNRD1 thioredoxin reductase 1 -0.121342
GRAMD1B GRAM domain containing 1B -0.119135
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.104185
TMSB10 thymosin beta 10 -0.0940739
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0824187
EGR1 early growth response 1 -0.070277
TFPI2 tissue factor pathway inhibitor 2 -0.0653544
PDE4D phosphodiesterase 4D, cAMP-specific -0.0561597
OSMR oncostatin M receptor -0.0540114
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0528065
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0509687
KYNU kynureninase -0.0477912
HDAC9 histone deacetylase 9 -0.0455724
RPL19 ribosomal protein L19 -0.0404392
SLC38A2 solute carrier family 38, member 2 -0.0394682
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0390785
IGF2 insulin-like growth factor 2 -0.0382326
NTN4 netrin 4 -0.0374241
WWOX WW domain containing oxidoreductase -0.036025
RPLP0 ribosomal protein, large, P0 -0.0335063
RPLP1 ribosomal protein, large, P1 -0.0322842
VMP1 vacuole membrane protein 1 -0.0319802
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0319073
RAD21 RAD21 homolog (S. pombe) -0.0313938
EIF1 eukaryotic translation initiation factor 1 -0.0313552
NCOA7 nuclear receptor coactivator 7 -0.0310097
RPL23 ribosomal protein L23 -0.0309364
RAD51B RAD51 paralog B -0.0293729
KLF6 Kruppel-like factor 6 -0.0277898
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0274032
SPIDR scaffolding protein involved in DNA repair -0.0267883
TPT1 tumor protein, translationally-controlled 1 -0.0263125
THSD4 thrombospondin, type I, domain containing 4 -0.0259595
RHOA ras homolog family member A -0.0254511
LOC102724023 ES1 protein homolog, mitochondrial -0.0253475
PDE10A phosphodiesterase 10A -0.0244472
BICC1 BicC family RNA binding protein 1 -0.0238399
IGF1R insulin-like growth factor 1 receptor -0.0236391
FGG fibrinogen gamma chain -0.0234572
MT1X metallothionein 1X -0.0224947
RPL8 ribosomal protein L8 -0.0222262
RPS21 ribosomal protein S21 -0.0220474
FGB fibrinogen beta chain -0.0218525
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.021757
MBNL1 muscleblind-like splicing regulator 1 -0.0212457
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.0202496
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0202152
FBXL17 F-box and leucine-rich repeat protein 17 -0.0197384
AGO2 argonaute RISC catalytic component 2 -0.0193854
KPNB1 karyopherin (importin) beta 1 -0.019291
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0189703
NABP1 nucleic acid binding protein 1 -0.018831
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0186417
STEAP1B STEAP family member 1B -0.0182406
TUBB tubulin, beta class I -0.0172802
BICD1 bicaudal D homolog 1 (Drosophila) -0.0169769
RPS5 ribosomal protein S5 -0.0169565
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0169401
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0168862
RPS23 ribosomal protein S23 -0.0167717
MAML3 mastermind-like 3 (Drosophila) -0.0166812
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0163745
MIPOL1 mirror-image polydactyly 1 -0.0161867
ATP5F1B ATP synthase F1 subunit beta -0.0158437
ASPH aspartate beta-hydroxylase -0.0155292
TBC1D32 TBC1 domain family, member 32 -0.0154232
CXCL2 chemokine (C-X-C motif) ligand 2 -0.0152353
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0151392
GSTP1 glutathione S-transferase pi 1 -0.0149909
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0148729
RIMS2 regulating synaptic membrane exocytosis 2 -0.0148296
NSUN6 NOP2/Sun domain family, member 6 -0.0147663
ZNF804A zinc finger protein 804A -0.014669
MASTL microtubule associated serine/threonine kinase-like -0.0145925
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0144207
ATP5F1E ATP synthase F1 subunit epsilon -0.0143089
RPL36 ribosomal protein L36 -0.0142182
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0139858
TCIM transcriptional and immune response regulator -0.0138177
DTNB dystrobrevin, beta -0.0137324
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0137089
PRR11 proline rich 11 -0.0135988
RSPO3 R-spondin 3 -0.0135653
SSH1 slingshot protein phosphatase 1 -0.0135565
IER2 immediate early response 2 -0.0134421
STAU2 staufen double-stranded RNA binding protein 2 -0.0134383
PCLO piccolo presynaptic cytomatrix protein -0.0134128
AREG amphiregulin -0.0134113
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0132945
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0132806
AKAP12 A kinase (PRKA) anchor protein 12 -0.0132407
CDK12 cyclin-dependent kinase 12 -0.0132072
SERF2 small EDRK-rich factor 2 -0.0131744
RPS20 ribosomal protein S20 -0.0130057
TNPO1 transportin 1 -0.0126841
RPL35A ribosomal protein L35a -0.0126814
R3HDM2 R3H domain containing 2 -0.0126294