| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sildenafil_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.104323 |
| VGF | VGF nerve growth factor inducible | 0.084023 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0837524 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0783904 |
| FN1 | fibronectin 1 | 0.0724522 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0706136 |
| GOLGA4 | golgin A4 | 0.0636427 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.063347 |
| HELZ | helicase with zinc finger | 0.0632071 |
| DST | dystonin | 0.0581942 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.057931 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0578432 |
| PTK2 | protein tyrosine kinase 2 | 0.0556472 |
| NDRG1 | N-myc downstream regulated 1 | 0.0550853 |
| NBAS | neuroblastoma amplified sequence | 0.0498889 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0497283 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0493187 |
| PDE10A | phosphodiesterase 10A | 0.0457578 |
| SETD5 | SET domain containing 5 | 0.0441523 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.044147 |
| CALR | calreticulin | 0.0435885 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.042507 |
| NKTR | natural killer cell triggering receptor | 0.0424544 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0423283 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.041952 |
| CDC73 | cell division cycle 73 | 0.0416782 |
| RTN4 | reticulon 4 | 0.0410292 |
| TFG | TRK-fused gene | 0.0406085 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0403035 |
| COL5A2 | collagen, type V, alpha 2 | 0.040245 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0398411 |
| MYOF | myoferlin | 0.0397297 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0395766 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0389989 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0384018 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0376525 |
| PRELID2 | PRELI domain containing 2 | 0.037449 |
| RNF24 | ring finger protein 24 | 0.0359939 |
| PHF21A | PHD finger protein 21A | 0.0352069 |
| NAV2 | neuron navigator 2 | 0.0351922 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0350362 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.034823 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0348158 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0347964 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0342504 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0341695 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0341232 |
| ANXA5 | annexin A5 | 0.0340129 |
| TPR | translocated promoter region, nuclear basket protein | 0.033412 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0332779 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0329776 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0323615 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0318823 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0318783 |
| PCBP3 | poly(rC) binding protein 3 | 0.0317878 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0316992 |
| CANX | calnexin | 0.0316959 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0316686 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0316162 |
| NFIA | nuclear factor I/A | 0.0315486 |
| AZIN1 | antizyme inhibitor 1 | 0.0314557 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0314147 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0311418 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0310232 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0309965 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0309501 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0306779 |
| COPA | coatomer protein complex, subunit alpha | 0.0306539 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0306066 |
| RYBP | RING1 and YY1 binding protein | 0.0303993 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0301631 |
| NGLY1 | N-glycanase 1 | 0.0300474 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0299837 |
| ATP11B | ATPase, class VI, type 11B | 0.0299618 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0299051 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0298874 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0295973 |
| SPAG9 | sperm associated antigen 9 | 0.0294978 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0294387 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0293863 |
| SBF2 | SET binding factor 2 | 0.0291905 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0291231 |
| NBEAL1 | neurobeachin-like 1 | 0.0289048 |
| FMN1 | formin 1 | 0.0289017 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0287873 |
| ATP11A | ATPase, class VI, type 11A | 0.0287476 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0285339 |
| UBQLN1 | ubiquilin 1 | 0.0285112 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.028483 |
| ATP13A3 | ATPase type 13A3 | 0.0284159 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0283866 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.028212 |
| SEC24A | SEC24 family member A | 0.0280888 |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide | 0.028036 |
| CD109 | CD109 molecule | 0.0279007 |
| COLEC11 | collectin sub-family member 11 | 0.0278054 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0277806 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0277601 |
| USP48 | ubiquitin specific peptidase 48 | 0.027703 |
| CFDP1 | craniofacial development protein 1 | 0.0276552 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.237109 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.147984 |
| LAMB3 | laminin, beta 3 | -0.145508 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.141085 |
| ATOSA | atos homolog A | -0.126419 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.124438 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.12421 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.10624 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0902132 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0896915 |
| TXNRD1 | thioredoxin reductase 1 | -0.0880693 |
| SVIL | supervillin | -0.085897 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0823901 |
| ABHD17C | abhydrolase domain containing 17C | -0.0820811 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.079784 |
| RBM47 | RNA binding motif protein 47 | -0.0763792 |
| MUC16 | mucin 16, cell surface associated | -0.0752124 |
| PARD3 | par-3 family cell polarity regulator | -0.0751716 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0739507 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0711312 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0670534 |
| EZR | ezrin | -0.0632062 |
| HMGA2 | high mobility group AT-hook 2 | -0.0622206 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0599677 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0586949 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0584687 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0571642 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0561004 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0552943 |
| TJP1 | tight junction protein 1 | -0.0545912 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0543041 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0541452 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0517014 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0509494 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0508376 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0507495 |
| JMJD1C | jumonji domain containing 1C | -0.0501813 |
| AHNAK | AHNAK nucleoprotein | -0.0498555 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0489632 |
| ZNF638 | zinc finger protein 638 | -0.0481316 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0476578 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0473437 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0464841 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0461762 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0445412 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0438832 |
| STC1 | stanniocalcin 1 | -0.043671 |
| FOXP1 | forkhead box P1 | -0.0435675 |
| MACC1 | metastasis associated in colon cancer 1 | -0.043263 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0423638 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0420132 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0414989 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.040209 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0398864 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0389869 |
| CMIP | c-Maf inducing protein | -0.0386664 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0378661 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0377582 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0377113 |
| TXNIP | thioredoxin interacting protein | -0.0374468 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0368255 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0367854 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.036657 |
| LAMC2 | laminin, gamma 2 | -0.0366466 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.03663 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0363767 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0363003 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0362701 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0361716 |
| ERBIN | erbb2 interacting protein | -0.0359548 |
| KLF6 | Kruppel-like factor 6 | -0.0349469 |
| ZNF207 | zinc finger protein 207 | -0.0346406 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0346327 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0344087 |
| KIF13B | kinesin family member 13B | -0.0338507 |
| TUSC3 | tumor suppressor candidate 3 | -0.0338479 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0336354 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0335327 |
| ITGB4 | integrin, beta 4 | -0.0334812 |
| DIAPH1 | diaphanous-related formin 1 | -0.0331852 |
| CDK13 | cyclin-dependent kinase 13 | -0.0330644 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0330016 |
| TBL1X | transducin (beta)-like 1X-linked | -0.032877 |
| PRKCA | protein kinase C, alpha | -0.0327829 |
| SIK3 | SIK family kinase 3 | -0.0325549 |
| EGFR | epidermal growth factor receptor | -0.0322363 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0320843 |
| FOXO1 | forkhead box O1 | -0.0316502 |
| CCNI | cyclin I | -0.0316392 |
| MCL1 | myeloid cell leukemia 1 | -0.0315781 |
| TMSB10 | thymosin beta 10 | -0.0315059 |
| HPCAL1 | hippocalcin-like 1 | -0.0311531 |
| ETV6 | ets variant 6 | -0.0311303 |
| NCOR2 | nuclear receptor corepressor 2 | -0.030997 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0306433 |
| MCU | mitochondrial calcium uniporter | -0.0305756 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0305349 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | -0.0302825 |
| BPTF | bromodomain PHD finger transcription factor | -0.0301284 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0301074 |
