| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sildenafil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0734574 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0704402 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0531802 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0506849 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0480114 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0447743 |
| MCL1 | myeloid cell leukemia 1 | 0.0428242 |
| PTK2 | protein tyrosine kinase 2 | 0.0420612 |
| SMAD3 | SMAD family member 3 | 0.0393525 |
| FMNL2 | formin-like 2 | 0.0389983 |
| COPA | coatomer protein complex, subunit alpha | 0.0381213 |
| CCNL1 | cyclin L1 | 0.0380954 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0380445 |
| PDE10A | phosphodiesterase 10A | 0.0358514 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0344606 |
| PHF21A | PHD finger protein 21A | 0.0324467 |
| DENND1A | DENN/MADD domain containing 1A | 0.0323602 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0315853 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0309021 |
| TFG | TRK-fused gene | 0.0295603 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0289685 |
| ATXN1 | ataxin 1 | 0.0286656 |
| AHNAK | AHNAK nucleoprotein | 0.0282101 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0278557 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0277997 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0275857 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0273948 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0273813 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0273019 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0272811 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0261467 |
| PARD3 | par-3 family cell polarity regulator | 0.0258727 |
| HMGA2 | high mobility group AT-hook 2 | 0.0253715 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0243588 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0240141 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0238902 |
| MSI2 | musashi RNA-binding protein 2 | 0.0235808 |
| OSMR | oncostatin M receptor | 0.0235757 |
| RAD51B | RAD51 paralog B | 0.0235479 |
| DIDO1 | death inducer-obliterator 1 | 0.0234633 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0233647 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0232786 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0227456 |
| ATP13A3 | ATPase type 13A3 | 0.0222186 |
| RAB1A | RAB1A, member RAS oncogene family | 0.022208 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0220738 |
| EXOC4 | exocyst complex component 4 | 0.0219394 |
| NF1 | neurofibromin 1 | 0.0215611 |
| SMYD3 | SET and MYND domain containing 3 | 0.0210572 |
| DENND5B | DENN/MADD domain containing 5B | 0.0209973 |
| VCL | vinculin | 0.0209104 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0208785 |
| EHBP1 | EH domain binding protein 1 | 0.0207735 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0206775 |
| RNF213 | ring finger protein 213 | 0.0206611 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0200326 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0196911 |
| TMEM165 | transmembrane protein 165 | 0.019573 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0195544 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0195212 |
| AEBP2 | AE binding protein 2 | 0.0193446 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0192671 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0192466 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0191875 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0187389 |
| RBM39 | RNA binding motif protein 39 | 0.0186179 |
| VMP1 | vacuole membrane protein 1 | 0.0185713 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0184743 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.018259 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0180819 |
| RLIM | ring finger protein, LIM domain interacting | 0.0178624 |
| FAM168A | family with sequence similarity 168, member A | 0.0178007 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0177843 |
| FOXJ3 | forkhead box J3 | 0.0176934 |
| KIAA1328 | KIAA1328 | 0.0176844 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0176679 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0176108 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.017582 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0175658 |
| WDR43 | WD repeat domain 43 | 0.0173307 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0172501 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0172131 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0170309 |
| CDK17 | cyclin-dependent kinase 17 | 0.0170107 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0169483 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0168632 |
| YAP1 | Yes-associated protein 1 | 0.0167366 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0166364 |
| RREB1 | ras responsive element binding protein 1 | 0.0166334 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0165142 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0164927 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0164918 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0163312 |
| SPPL3 | signal peptide peptidase like 3 | 0.0161867 |
| PRELID2 | PRELI domain containing 2 | 0.0158485 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0157226 |
| ATL2 | atlastin GTPase 2 | 0.0155832 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0155816 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0155474 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0155062 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.263194 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.149018 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.123582 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10848 |
| PTMA | prothymosin, alpha | -0.103148 |
| YBX3 | Y box binding protein 3 | -0.0913481 |
| RPS8 | ribosomal protein S8 | -0.0747079 |
| TPI1 | triosephosphate isomerase 1 | -0.0734429 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.069344 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0668817 |
| RPS3 | ribosomal protein S3 | -0.0647397 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0643839 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0617458 |
| VIM | vimentin | -0.0609017 |
| RPL26 | ribosomal protein L26 | -0.0595008 |
| RPL37 | ribosomal protein L37 | -0.058157 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0575327 |
| TMSB10 | thymosin beta 10 | -0.0565207 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.055898 |
| RPS2 | ribosomal protein S2 | -0.0535413 |
| MKI67 | marker of proliferation Ki-67 | -0.0525471 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0519222 |
| RPL37A | ribosomal protein L37a | -0.0483784 |
| RPL12 | ribosomal protein L12 | -0.0480581 |
| ACTG1 | actin gamma 1 | -0.0463474 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0457479 |
| RPS29 | ribosomal protein S29 | -0.0443262 |
| RPS21 | ribosomal protein S21 | -0.0442805 |
| RPS12 | ribosomal protein S12 | -0.0439705 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0433432 |
| RPLP1 | ribosomal protein, large, P1 | -0.0429079 |
| RPLP2 | ribosomal protein, large, P2 | -0.0424712 |
| RPS15 | ribosomal protein S15 | -0.0422477 |
| RPL38 | ribosomal protein L38 | -0.0416585 |
| RPL19 | ribosomal protein L19 | -0.0411471 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0396097 |
| MT2A | metallothionein 2A | -0.0394364 |
| SET | SET nuclear proto-oncogene | -0.0394195 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0392072 |
| RPS19 | ribosomal protein S19 | -0.0387019 |
| TXNRD1 | thioredoxin reductase 1 | -0.0383816 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0381295 |
| RPS27 | ribosomal protein S27 | -0.0379979 |
| CENPF | centromere protein F, 350/400kDa | -0.0379284 |
| RPL23 | ribosomal protein L23 | -0.0374678 |
| RPS6 | ribosomal protein S6 | -0.0363941 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0363678 |
| RPS27A | ribosomal protein S27a | -0.036162 |
| RPL9 | ribosomal protein L9 | -0.0353802 |
| RPL7A | ribosomal protein L7a | -0.0351242 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0334977 |
| RPL32 | ribosomal protein L32 | -0.0332278 |
| RPL5 | ribosomal protein L5 | -0.0328336 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0327024 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0326672 |
| SEPTIN7 | septin 7 | -0.0324874 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0322714 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0315071 |
| STC1 | stanniocalcin 1 | -0.0314909 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0313631 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0313038 |
| TPM3 | tropomyosin 3 | -0.0311149 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0309652 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0309137 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0305002 |
| RPL11 | ribosomal protein L11 | -0.0304929 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0304635 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0304264 |
| HLA-B | major histocompatibility complex, class I, B | -0.0302185 |
| RPS17 | ribosomal protein S17 | -0.0301469 |
| RPS10 | ribosomal protein S10 | -0.0300175 |
| YBX1 | Y box binding protein 1 | -0.0298393 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.029756 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0297049 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0295756 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0294168 |
| RACK1 | receptor for activated C kinase 1 | -0.0289711 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0288203 |
| PFN1 | profilin 1 | -0.0286598 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0286246 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0285061 |
| CBX3 | chromobox homolog 3 | -0.0278379 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0275772 |
| RPLP0 | ribosomal protein, large, P0 | -0.0275384 |
| IGF2 | insulin-like growth factor 2 | -0.0275169 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0272622 |
| LDHB | lactate dehydrogenase B | -0.027247 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0272339 |
| RPL36 | ribosomal protein L36 | -0.027212 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0271139 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0270559 |
| KRT18 | keratin 18, type I | -0.026808 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0265963 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0264106 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0262765 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0262347 |
| CAVIN1 | caveolae associated protein 1 | -0.0261423 |
| RPL28 | ribosomal protein L28 | -0.0256425 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0248764 |
| RPL30 | ribosomal protein L30 | -0.0247243 |
