Sildenafil_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.134915
SAMD4A sterile alpha motif domain containing 4A 0.0894758
FNDC3B fibronectin type III domain containing 3B 0.0733117
LIMCH1 LIM and calponin homology domains 1 0.0688712
LPP LIM domain containing preferred translocation partner in lipoma 0.0685665
IGFBP3 insulin-like growth factor binding protein 3 0.0669936
AHNAK AHNAK nucleoprotein 0.0526054
EFNA5 ephrin-A5 0.047994
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0424669
PTK2 protein tyrosine kinase 2 0.0420277
EXT1 exostosin glycosyltransferase 1 0.0396729
MSI2 musashi RNA-binding protein 2 0.0393428
TRIO trio Rho guanine nucleotide exchange factor 0.0366387
CCND1 cyclin D1 0.0364767
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0359431
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0343363
PLEC plectin 0.0338143
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0316458
VCL vinculin 0.0311015
CD109 CD109 molecule 0.0304493
SEC31A SEC31 homolog A (S. cerevisiae) 0.0266044
CTBP2 C-terminal binding protein 2 0.0265036
AHNAK2 AHNAK nucleoprotein 2 0.026453
FNIP1 folliculin interacting protein 1 0.0259215
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0259077
SH3KBP1 SH3-domain kinase binding protein 1 0.0258454
BZW1 basic leucine zipper and W2 domains 1 0.0255369
TM4SF1 transmembrane 4 L six family member 1 0.0253716
OSBPL3 oxysterol binding protein-like 3 0.0249387
RAI14 retinoic acid induced 14 0.0243027
ZBTB20 zinc finger and BTB domain containing 20 0.0241978
IRF6 interferon regulatory factor 6 0.0241483
MCU mitochondrial calcium uniporter 0.0239198
ANKRD11 ankyrin repeat domain 11 0.0237889
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0237514
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0236373
KDM5B lysine (K)-specific demethylase 5B 0.0236352
STRN3 striatin, calmodulin binding protein 3 0.0235643
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0235534
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0235126
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.023461
PLAU plasminogen activator, urokinase 0.023137
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0229641
PDLIM5 PDZ and LIM domain 5 0.0227738
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0217513
COPA coatomer protein complex, subunit alpha 0.0208193
FBXO34 F-box protein 34 0.0207074
KRT8 keratin 8, type II 0.0206859
LMO7 LIM domain 7 0.020452
MAML2 mastermind-like 2 (Drosophila) 0.0202403
FLNB filamin B, beta 0.0199956
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0199428
MX2 MX dynamin-like GTPase 2 0.0198427
BLZF1 basic leucine zipper nuclear factor 1 0.0197754
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0196165
KMT2C lysine (K)-specific methyltransferase 2C 0.0195846
CERT1 ceramide transporter 1 0.0195786
MACF1 microtubule-actin crosslinking factor 1 0.0194011
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0190953
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.019032
FBXL2 F-box and leucine-rich repeat protein 2 0.0190003
RASAL2 RAS protein activator like 2 0.0189797
AOPEP aminopeptidase O (putative) 0.0189242
RNF213 ring finger protein 213 0.0186819
PPARD peroxisome proliferator-activated receptor delta 0.0185388
AKAP13 A kinase (PRKA) anchor protein 13 0.0183204
MAML3 mastermind-like 3 (Drosophila) 0.0181922
SOX4 SRY (sex determining region Y)-box 4 0.018069
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0180302
PARP14 poly (ADP-ribose) polymerase family, member 14 0.017901
TIMP2 TIMP metallopeptidase inhibitor 2 0.0178776
ETV6 ets variant 6 0.0178317
ARHGAP20 Rho GTPase activating protein 20 0.0178145
WARS1 tryptophanyl-tRNA synthetase 1 0.0177063
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0176682
PTPRK protein tyrosine phosphatase, receptor type, K 0.017628
LAMB3 laminin, beta 3 0.0171561
TTC3 tetratricopeptide repeat domain 3 0.0171546
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0171325
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0170888
TMEM123 transmembrane protein 123 0.0170711
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0170334
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0169642
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0167727
ZSWIM6 zinc finger, SWIM-type containing 6 0.0167522
UBAP1 ubiquitin associated protein 1 0.0167411
SIK3 SIK family kinase 3 0.0167206
PICALM phosphatidylinositol binding clathrin assembly protein 0.0165905
IFI16 interferon, gamma-inducible protein 16 0.0164546
DUSP10 dual specificity phosphatase 10 0.0162966
SEC24D SEC24 family member D 0.0161665
ANKIB1 ankyrin repeat and IBR domain containing 1 0.01613
UBE2H ubiquitin-conjugating enzyme E2H 0.016026
H1-0 H1.0 linker histone 0.0159339
RIGI RNA sensor RIG-I 0.015914
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0159082
WASF2 WAS protein family, member 2 0.0157538
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0156252
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0154871
ENO2 enolase 2 (gamma, neuronal) 0.0154223

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232069
NDRG1 N-myc downstream regulated 1 -0.226532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.211645
POTEF POTE ankyrin domain family, member F -0.163906
FTL ferritin, light polypeptide -0.15429
S100A6 S100 calcium binding protein A6 -0.109216
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0995716
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0911166
MT2A metallothionein 2A -0.0889787
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0845634
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0836802
RPS6 ribosomal protein S6 -0.0822671
GOLGA4 golgin A4 -0.0814411
PTMA prothymosin, alpha -0.0806272
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0800577
RPS2 ribosomal protein S2 -0.0759526
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0745939
ASPH aspartate beta-hydroxylase -0.0742395
RPLP2 ribosomal protein, large, P2 -0.0726562
RPS3 ribosomal protein S3 -0.0712284
TPT1 tumor protein, translationally-controlled 1 -0.0700518
EIF1 eukaryotic translation initiation factor 1 -0.0694188
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0666324
RPL8 ribosomal protein L8 -0.0660715
ACTG1 actin gamma 1 -0.0656868
HMGA1 high mobility group AT-hook 1 -0.0647563
RPL32 ribosomal protein L32 -0.0647061
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0640237
RPLP1 ribosomal protein, large, P1 -0.0631918
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0631545
RPS23 ribosomal protein S23 -0.0624749
RPS8 ribosomal protein S8 -0.0619671
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0600016
RPL9 ribosomal protein L9 -0.0595883
RPS19 ribosomal protein S19 -0.0587889
HSPA8 heat shock 70kDa protein 8 -0.058409
LAMC2 laminin, gamma 2 -0.057812
RPS12 ribosomal protein S12 -0.0577168
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0555802
RPL37A ribosomal protein L37a -0.0553979
SLC38A1 solute carrier family 38, member 1 -0.0542345
RPL7 ribosomal protein L7 -0.0534448
RPL11 ribosomal protein L11 -0.0525557
UBC ubiquitin C -0.0518465
RPL12 ribosomal protein L12 -0.0517769
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0512691
RACK1 receptor for activated C kinase 1 -0.0505948
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0496737
RPL37 ribosomal protein L37 -0.0492767
RPS13 ribosomal protein S13 -0.048592
HMGB2 high mobility group box 2 -0.0484731
RPL19 ribosomal protein L19 -0.048268
BHLHE40 basic helix-loop-helix family, member e40 -0.0482195
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0468195
NAMPT nicotinamide phosphoribosyltransferase -0.0462079
RPS29 ribosomal protein S29 -0.0455528
PRRC2C proline-rich coiled-coil 2C -0.0444518
FN1 fibronectin 1 -0.0438408
DSTN destrin (actin depolymerizing factor) -0.0432763
RPLP0 ribosomal protein, large, P0 -0.0430116
TXNRD1 thioredoxin reductase 1 -0.0425533
RPL34 ribosomal protein L34 -0.0422371
MKI67 marker of proliferation Ki-67 -0.0420069
TMSB10 thymosin beta 10 -0.0416554
RPS27A ribosomal protein S27a -0.041526
TMSB4X thymosin beta 4, X-linked -0.0409843
RPL23 ribosomal protein L23 -0.0408284
RPS14 ribosomal protein S14 -0.0407375
RPL5 ribosomal protein L5 -0.0405865
RPL28 ribosomal protein L28 -0.0403558
PAPOLA poly(A) polymerase alpha -0.0401829
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0401115
RPL15 ribosomal protein L15 -0.0390977
KTN1 kinectin 1 (kinesin receptor) -0.0390507
RPS17 ribosomal protein S17 -0.0390381
RPL26 ribosomal protein L26 -0.0383849
RPL30 ribosomal protein L30 -0.0381657
GPX4 glutathione peroxidase 4 -0.0380103
RBM25 RNA binding motif protein 25 -0.0367812
AREG amphiregulin -0.0358317
RPS27 ribosomal protein S27 -0.0358261
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0356422
RPL27A ribosomal protein L27a -0.0346002
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0345502
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0342506
RPS25 ribosomal protein S25 -0.0340613
S100A9 S100 calcium binding protein A9 -0.0336053
RPL38 ribosomal protein L38 -0.0335623
RPS5 ribosomal protein S5 -0.0334308
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0332493
BRD2 bromodomain containing 2 -0.0331927
ALCAM activated leukocyte cell adhesion molecule -0.0322255
NAP1L1 nucleosome assembly protein 1-like 1 -0.0321724
YBX3 Y box binding protein 3 -0.0321669
SDC4 syndecan 4 -0.0320818
GPBP1 GC-rich promoter binding protein 1 -0.0318656
EPCAM epithelial cell adhesion molecule -0.0318153
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0314061
CCNI cyclin I -0.031119
RPL36 ribosomal protein L36 -0.0309625