Sildenafil_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.153481
TRIO trio Rho guanine nucleotide exchange factor 0.103866
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0846964
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0705664
ASPH aspartate beta-hydroxylase 0.0705587
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0661547
LIMCH1 LIM and calponin homology domains 1 0.0646794
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0641482
TXNRD1 thioredoxin reductase 1 0.0627968
DST dystonin 0.0621737
NEK7 NIMA-related kinase 7 0.0606279
FNDC3B fibronectin type III domain containing 3B 0.0601197
NAMPT nicotinamide phosphoribosyltransferase 0.0559148
RTN4 reticulon 4 0.0543726
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0539472
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0536704
SAMD4A sterile alpha motif domain containing 4A 0.0536575
MCL1 myeloid cell leukemia 1 0.0534274
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0502996
KDM6A lysine (K)-specific demethylase 6A 0.0484119
PTEN phosphatase and tensin homolog 0.0480805
SPAG9 sperm associated antigen 9 0.0458266
RBM39 RNA binding motif protein 39 0.0433846
KMT2C lysine (K)-specific methyltransferase 2C 0.04164
MYOF myoferlin 0.0402854
KYNU kynureninase 0.0375233
DOCK4 dedicator of cytokinesis 4 0.0369136
NBAS neuroblastoma amplified sequence 0.0362022
ATP13A3 ATPase type 13A3 0.0347123
BIRC6 baculoviral IAP repeat containing 6 0.0345196
WDR43 WD repeat domain 43 0.0343592
TGFBR1 transforming growth factor, beta receptor 1 0.0343409
GDA guanine deaminase 0.034328
CARD16 caspase recruitment domain family, member 16 0.0341232
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0339423
GRAMD1B GRAM domain containing 1B 0.0335641
PUM2 pumilio RNA-binding family member 2 0.0333283
OGA O-GlcNAcase 0.0329431
PCBP2 poly(rC) binding protein 2 0.0327849
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0327453
MSN moesin 0.0327218
COL4A6 collagen, type IV, alpha 6 0.0322048
CHD1 chromodomain helicase DNA binding protein 1 0.0320541
COL8A1 collagen, type VIII, alpha 1 0.0319638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0309183
UBA6 ubiquitin-like modifier activating enzyme 6 0.0308979
PTK2 protein tyrosine kinase 2 0.0308469
ERRFI1 ERBB receptor feedback inhibitor 1 0.0302741
PLCB4 phospholipase C, beta 4 0.0301146
USP9X ubiquitin specific peptidase 9, X-linked 0.0300994
TRA2A transformer 2 alpha homolog (Drosophila) 0.0300925
NUP58 nucleoporin 58 0.0299517
GOLGA4 golgin A4 0.0281713
CENPF centromere protein F, 350/400kDa 0.0274983
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0273653
HELZ helicase with zinc finger 0.0271467
PSME4 proteasome (prosome, macropain) activator subunit 4 0.027137
USP34 ubiquitin specific peptidase 34 0.027054
TSC22D2 TSC22 domain family, member 2 0.0269476
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0268641
RNF145 ring finger protein 145 0.0266743
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0266323
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0263063
ADAM9 ADAM metallopeptidase domain 9 0.0262846
ECT2 epithelial cell transforming 2 0.0262253
NCKAP1 NCK-associated protein 1 0.0261661
RUNX1 runt-related transcription factor 1 0.0259052
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0250892
FAM13A family with sequence similarity 13, member A 0.0249393
DPY19L1 dpy-19-like 1 (C. elegans) 0.0249019
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0248264
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0247083
ADAM17 ADAM metallopeptidase domain 17 0.0244658
CD109 CD109 molecule 0.0244228
CTSC cathepsin C 0.0243506
ELL2 elongation factor, RNA polymerase II, 2 0.0243466
PICALM phosphatidylinositol binding clathrin assembly protein 0.0242223
ARHGAP29 Rho GTPase activating protein 29 0.0242216
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0241643
MED13L mediator complex subunit 13-like 0.0241436
CDC73 cell division cycle 73 0.0241124
CTIF CBP80/20-dependent translation initiation factor 0.0241093
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0239824
SUCO SUN domain containing ossification factor 0.0239182
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0237738
SFPQ splicing factor proline/glutamine-rich 0.0237599
MCTP1 multiple C2 domains, transmembrane 1 0.0236813
CUL3 cullin 3 0.0236675
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0234722
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0231487
AGFG1 ArfGAP with FG repeats 1 0.0230693
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0228646
RLIM ring finger protein, LIM domain interacting 0.0228641
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0227784
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0227347
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0226452
ANKRD17 ankyrin repeat domain 17 0.022456
NRCAM neuronal cell adhesion molecule 0.0224222
LAMA1 laminin, alpha 1 0.0222593
PDLIM5 PDZ and LIM domain 5 0.0221785

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.306081
FN1 fibronectin 1 -0.235759
VIM vimentin -0.145652
TPT1 tumor protein, translationally-controlled 1 -0.13791
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129862
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.125318
RPLP1 ribosomal protein, large, P1 -0.109072
TMSB10 thymosin beta 10 -0.102384
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0856574
RPS6 ribosomal protein S6 -0.0826019
FTL ferritin, light polypeptide -0.0814809
RPL26 ribosomal protein L26 -0.0809057
PDE4D phosphodiesterase 4D, cAMP-specific -0.0787253
PTMA prothymosin, alpha -0.0754773
RPL31 ribosomal protein L31 -0.0728767
RPS8 ribosomal protein S8 -0.0702141
RPS24 ribosomal protein S24 -0.0690669
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0656834
RPL35A ribosomal protein L35a -0.0654789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0640329
RPL37A ribosomal protein L37a -0.0632547
RPL12 ribosomal protein L12 -0.0628399
RPS27A ribosomal protein S27a -0.0563295
SOX4 SRY (sex determining region Y)-box 4 -0.0550937
RPS19 ribosomal protein S19 -0.0544887
RPS12 ribosomal protein S12 -0.0542361
RPLP0 ribosomal protein, large, P0 -0.0542265
RPS3 ribosomal protein S3 -0.0535225
RPL36A ribosomal protein L36a -0.0511352
RPL38 ribosomal protein L38 -0.0481621
RPS27 ribosomal protein S27 -0.0479774
RPL19 ribosomal protein L19 -0.0479152
RPL37 ribosomal protein L37 -0.0475976
S100A6 S100 calcium binding protein A6 -0.0468816
RPL34 ribosomal protein L34 -0.0464106
HLA-B major histocompatibility complex, class I, B -0.0446056
RPL7A ribosomal protein L7a -0.0443787
RPS23 ribosomal protein S23 -0.044295
CTSL cathepsin L -0.0433167
RPL9 ribosomal protein L9 -0.0429858
RPS29 ribosomal protein S29 -0.0425744
RPL23 ribosomal protein L23 -0.0416347
STC1 stanniocalcin 1 -0.0414938
MT2A metallothionein 2A -0.0414109
RPLP2 ribosomal protein, large, P2 -0.041179
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0399589
PCBP3 poly(rC) binding protein 3 -0.0394776
RPL36 ribosomal protein L36 -0.0379301
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0375293
CDH13 cadherin 13 -0.0369897
RPL11 ribosomal protein L11 -0.0366949
RACK1 receptor for activated C kinase 1 -0.0359343
RPS16 ribosomal protein S16 -0.0358368
EIF1 eukaryotic translation initiation factor 1 -0.0356322
RPS14 ribosomal protein S14 -0.0355786
S100A10 S100 calcium binding protein A10 -0.0350105
RPL13A ribosomal protein L13a -0.0348189
MAP7 microtubule-associated protein 7 -0.0347093
NAP1L1 nucleosome assembly protein 1-like 1 -0.0341841
WSB1 WD repeat and SOCS box containing 1 -0.0333152
NALF1 NALCN channel auxiliary factor 1 -0.0330645
GNAS GNAS complex locus -0.0323939
RPS25 ribosomal protein S25 -0.0320823
INHBA inhibin, beta A -0.0319207
RPS4X ribosomal protein S4, X-linked -0.0312033
IER3 immediate early response 3 -0.0309238
TGFBI transforming growth factor, beta-induced, 68kDa -0.0300531
ADGRD1 adhesion G protein-coupled receptor D1 -0.030012
RPL35 ribosomal protein L35 -0.0297364
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0296771
TMSB4X thymosin beta 4, X-linked -0.029478
RPS21 ribosomal protein S21 -0.0289561
TFPI2 tissue factor pathway inhibitor 2 -0.0284067
RPL27 ribosomal protein L27 -0.0282838
RPS13 ribosomal protein S13 -0.028144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0279521
ESM1 endothelial cell-specific molecule 1 -0.0276564
NCKAP5 NCK-associated protein 5 -0.0273023
RPL32 ribosomal protein L32 -0.0272677
RPL28 ribosomal protein L28 -0.0269918
TENM3 teneurin transmembrane protein 3 -0.0269533
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0268251
PYGL phosphorylase, glycogen, liver -0.0267384
NCOA7 nuclear receptor coactivator 7 -0.0263131
B2M beta-2-microglobulin -0.0260774
FOXC1 forkhead box C1 -0.025059
RPL39 ribosomal protein L39 -0.0250436
CANX calnexin -0.0244857
BTG1 B-cell translocation gene 1, anti-proliferative -0.0241483
PCDH9 protocadherin 9 -0.0235976
RPS17 ribosomal protein S17 -0.0235327
ACTG1 actin gamma 1 -0.0233908
SQSTM1 sequestosome 1 -0.0233652
RPL8 ribosomal protein L8 -0.0232261
RHOB ras homolog family member B -0.0232133
RPS28 ribosomal protein S28 -0.0231039
IFIH1 interferon induced with helicase C domain 1 -0.0230961
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0227561
BASP1 brain abundant, membrane attached signal protein 1 -0.0225484
CHL1 cell adhesion molecule L1-like -0.022452