Sildenafil_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.132007
NAMPT nicotinamide phosphoribosyltransferase 0.112035
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.101763
PTK2 protein tyrosine kinase 2 0.0945558
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0871671
SLMAP sarcolemma associated protein 0.0854389
NDRG1 N-myc downstream regulated 1 0.0843224
SPAG9 sperm associated antigen 9 0.083796
CCNY cyclin Y 0.079981
NKD1 naked cuticle homolog 1 (Drosophila) 0.0770163
MYOF myoferlin 0.0744854
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.074025
HELZ helicase with zinc finger 0.0735571
USP34 ubiquitin specific peptidase 34 0.0734818
LDHA lactate dehydrogenase A 0.0731075
PGK1 phosphoglycerate kinase 1 0.0715578
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0694053
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0679059
NAP1L1 nucleosome assembly protein 1-like 1 0.0676164
DTNA dystrobrevin, alpha 0.0664018
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0647504
RCOR1 REST corepressor 1 0.0647326
PDE4D phosphodiesterase 4D, cAMP-specific 0.0640124
ZFAND3 zinc finger, AN1-type domain 3 0.0608624
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0601921
MED13 mediator complex subunit 13 0.0599096
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0591426
NABP1 nucleic acid binding protein 1 0.0588432
WAC WW domain containing adaptor with coiled-coil 0.0578479
PARD3 par-3 family cell polarity regulator 0.0575875
EXT1 exostosin glycosyltransferase 1 0.0556619
JARID2 jumonji, AT rich interactive domain 2 0.0543546
SEPTIN7 septin 7 0.0540847
FXR1 fragile X mental retardation, autosomal homolog 1 0.0523757
DST dystonin 0.051508
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0512954
NCOA3 nuclear receptor coactivator 3 0.0506188
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0494916
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.048629
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0474181
PDLIM5 PDZ and LIM domain 5 0.0473098
RORA RAR-related orphan receptor A 0.0465303
MATR3 matrin 3 0.045709
KMT2C lysine (K)-specific methyltransferase 2C 0.0451392
KDM3A lysine (K)-specific demethylase 3A 0.044766
PDIA3 protein disulfide isomerase family A, member 3 0.0443832
KDM7A lysine (K)-specific demethylase 7A 0.0442582
COL5A2 collagen, type V, alpha 2 0.0441521
YAP1 Yes-associated protein 1 0.0440979
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0438489
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0425536
CHD7 chromodomain helicase DNA binding protein 7 0.0425257
XRN2 5'-3' exoribonuclease 2 0.0422415
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0420076
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0414981
PTPRG protein tyrosine phosphatase, receptor type, G 0.040751
EIF4A1 eukaryotic translation initiation factor 4A1 0.0407409
ZNF292 zinc finger protein 292 0.0403908
RUNX1 runt-related transcription factor 1 0.039408
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0391252
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0388294
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.038783
STK24 serine/threonine kinase 24 0.0381898
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0378317
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0377796
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0371888
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0371586
UBA6 ubiquitin-like modifier activating enzyme 6 0.0371281
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0364222
ANKRD28 ankyrin repeat domain 28 0.03543
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0353394
MED13L mediator complex subunit 13-like 0.0351868
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0326526
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0322354
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0322041
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0321787
VIM vimentin 0.0319177
KIF5B kinesin family member 5B 0.0318565
BCLAF1 BCL2-associated transcription factor 1 0.0318287
PRRC2C proline-rich coiled-coil 2C 0.0316106
RPS23 ribosomal protein S23 0.0302704
GOLGA4 golgin A4 0.0299064
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0290583
RBM39 RNA binding motif protein 39 0.0282959
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0274504
MARCHF6 membrane associated ring-CH-type finger 6 0.027163
GNAS GNAS complex locus 0.0270028
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0267914
CANX calnexin 0.0266491
PTBP3 polypyrimidine tract binding protein 3 0.0266039
TAS2R14 taste receptor, type 2, member 14 0.0263771
TSC22D2 TSC22 domain family, member 2 0.0252815
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0248489
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0241633
WSB1 WD repeat and SOCS box containing 1 0.0241626
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0240654
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0234964
FLNB filamin B, beta 0.0232915
FAM13A family with sequence similarity 13, member A 0.0227029
PKM pyruvate kinase, muscle 0.0217241

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.207527
TMSB10 thymosin beta 10 -0.162177
LPP LIM domain containing preferred translocation partner in lipoma -0.151533
PTMA prothymosin, alpha -0.133985
SLTM SAFB-like, transcription modulator -0.129344
RPS6 ribosomal protein S6 -0.128676
THSD4 thrombospondin, type I, domain containing 4 -0.12683
PRKCA protein kinase C, alpha -0.116288
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102857
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.102656
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0992071
RPLP1 ribosomal protein, large, P1 -0.0951847
RPL37A ribosomal protein L37a -0.0937094
RPL34 ribosomal protein L34 -0.0927157
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0926356
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0918886
ANKRD12 ankyrin repeat domain 12 -0.0897407
ITGA6 integrin, alpha 6 -0.0892392
ANXA2 annexin A2 -0.0860771
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0818568
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0759899
RAB10 RAB10, member RAS oncogene family -0.0741472
MT2A metallothionein 2A -0.0736054
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0724644
LMO7 LIM domain 7 -0.0724299
B2M beta-2-microglobulin -0.0722139
NHSL1 NHS-like 1 -0.0707457
RPS21 ribosomal protein S21 -0.0655972
NFIA nuclear factor I/A -0.0638801
RPS27A ribosomal protein S27a -0.0638282
ATXN1 ataxin 1 -0.0616733
EFNA5 ephrin-A5 -0.0611925
RPL31 ribosomal protein L31 -0.060285
RPL30 ribosomal protein L30 -0.0589855
IGF2 insulin-like growth factor 2 -0.0588779
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0574755
FOXP1 forkhead box P1 -0.0566252
FCHSD2 FCH and double SH3 domains 2 -0.0537706
MED12 mediator complex subunit 12 -0.0531741
KTN1 kinectin 1 (kinesin receptor) -0.0510868
RPS27 ribosomal protein S27 -0.049588
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.047348
ASPH aspartate beta-hydroxylase -0.0467431
RPS8 ribosomal protein S8 -0.0462166
RPS16 ribosomal protein S16 -0.0441706
ACTG1 actin gamma 1 -0.0441121
RPL8 ribosomal protein L8 -0.0422521
FTL ferritin, light polypeptide -0.0416063
TPT1 tumor protein, translationally-controlled 1 -0.0414612
RPL23 ribosomal protein L23 -0.0413654
RPL15 ribosomal protein L15 -0.0407936
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0395574
SMYD3 SET and MYND domain containing 3 -0.0387744
RBM25 RNA binding motif protein 25 -0.037686
RPS12 ribosomal protein S12 -0.037613
RPS3 ribosomal protein S3 -0.037168
FN1 fibronectin 1 -0.0366987
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0365013
VCL vinculin -0.0350126
GSK3B glycogen synthase kinase 3 beta -0.0348414
AKAP12 A kinase (PRKA) anchor protein 12 -0.0297089
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0292448
RPL19 ribosomal protein L19 -0.0276142
DSCAM Down syndrome cell adhesion molecule -0.026678
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.026276
RNF213 ring finger protein 213 -0.0252818
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0249535
RPS19 ribosomal protein S19 -0.0240272
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0239019
TPR translocated promoter region, nuclear basket protein -0.0229476
TBC1D22A TBC1 domain family, member 22A -0.0225238
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0217808
TTC3 tetratricopeptide repeat domain 3 -0.0208662
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0188983
NALF1 NALCN channel auxiliary factor 1 -0.0184014
CAMTA1 calmodulin binding transcription activator 1 -0.017497
FNDC3B fibronectin type III domain containing 3B -0.0163846
PCBP2 poly(rC) binding protein 2 -0.0159402
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0141258
JMJD1C jumonji domain containing 1C -0.013507
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0130455
RYBP RING1 and YY1 binding protein -0.0126191
LCOR ligand dependent nuclear receptor corepressor -0.0123365
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0114053
GPBP1 GC-rich promoter binding protein 1 -0.0110834
FNBP1L formin binding protein 1-like -0.0107991
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0095421
RPL35A ribosomal protein L35a -0.00796658
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00765028
CNKSR3 CNKSR family member 3 -0.00652111
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00606689
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.00567865
ENO1 enolase 1, (alpha) -0.0054826
ANO6 anoctamin 6 -0.00469964
CALR calreticulin -0.00420256
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00363011
EIF3H eukaryotic translation initiation factor 3, subunit H -0.00289021
RPS13 ribosomal protein S13 -0.00277156
PDS5B PDS5 cohesin associated factor B -0.00190808
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.00130027