Sildenafil_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sildenafil_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.212679
TSC22D2 TSC22 domain family, member 2 0.134518
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.132852
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.121393
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.106363
ZNF292 zinc finger protein 292 0.0927284
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0913248
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0808051
MATR3 matrin 3 0.0716591
THBS1 thrombospondin 1 0.0650157
HDAC9 histone deacetylase 9 0.0640381
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0601592
CALR calreticulin 0.0558797
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0555173
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.055077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0547276
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0540906
DST dystonin 0.051535
USP3 ubiquitin specific peptidase 3 0.0494759
RYBP RING1 and YY1 binding protein 0.0482042
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0479538
PDGFC platelet derived growth factor C 0.0462253
MTF2 metal response element binding transcription factor 2 0.0455522
KMT2E lysine (K)-specific methyltransferase 2E 0.0441702
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0441333
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0440129
COL5A2 collagen, type V, alpha 2 0.0437095
NAMPT nicotinamide phosphoribosyltransferase 0.0433586
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0432232
CRY1 cryptochrome circadian clock 1 0.0425723
H1-4 H1.4 linker histone, cluster member 0.0423806
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0420751
ZFAND3 zinc finger, AN1-type domain 3 0.0420187
RHEB Ras homolog enriched in brain 0.0415327
TPM3 tropomyosin 3 0.0410427
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0400978
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0400371
CSDE1 cold shock domain containing E1, RNA-binding 0.03989
BCLAF1 BCL2-associated transcription factor 1 0.0393847
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.038837
NAP1L1 nucleosome assembly protein 1-like 1 0.0386065
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0376905
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0376501
ADAM9 ADAM metallopeptidase domain 9 0.0370307
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.0370142
RBM39 RNA binding motif protein 39 0.0369322
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0367645
YAP1 Yes-associated protein 1 0.0362844
SRSF1 serine/arginine-rich splicing factor 1 0.0361075
PUM2 pumilio RNA-binding family member 2 0.0359312
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0358476
ANXA1 annexin A1 0.0351115
RPL5 ribosomal protein L5 0.0350427
APP amyloid beta (A4) precursor protein 0.0349612
RAD21 RAD21 homolog (S. pombe) 0.034424
TBC1D12 TBC1 domain family, member 12 0.0343683
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0337628
SRSF3 serine/arginine-rich splicing factor 3 0.0337366
MACF1 microtubule-actin crosslinking factor 1 0.0335934
SPTSSA serine palmitoyltransferase, small subunit A 0.033573
TRA2A transformer 2 alpha homolog (Drosophila) 0.0334721
SEPTIN7 septin 7 0.0333357
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0333247
TMSB4X thymosin beta 4, X-linked 0.0330977
RPL3 ribosomal protein L3 0.0327756
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.032635
RBM33 RNA binding motif protein 33 0.0321384
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0320581
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0318706
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0312988
TCP1 t-complex 1 0.0312455
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0311534
NCKAP1 NCK-associated protein 1 0.0309927
RTN4 reticulon 4 0.0309709
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0308751
RAD23B RAD23 homolog B (S. cerevisiae) 0.0308097
FUBP1 far upstream element (FUSE) binding protein 1 0.030627
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0306241
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0301938
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0300028
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0298392
CFL2 cofilin 2 (muscle) 0.0297077
RPL4 ribosomal protein L4 0.0295658
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0293779
QKI QKI, KH domain containing, RNA binding 0.0293545
AKAP13 A kinase (PRKA) anchor protein 13 0.0290906
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0289911
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0289829
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0289537
U2SURP U2 snRNP-associated SURP domain containing 0.0288837
HSPH1 heat shock 105kDa/110kDa protein 1 0.02883
MB21D2 Mab-21 domain containing 2 0.0287962
USP9X ubiquitin specific peptidase 9, X-linked 0.0286645
SFPQ splicing factor proline/glutamine-rich 0.0286303
NOP58 NOP58 ribonucleoprotein 0.0285857
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0285663
SET SET nuclear proto-oncogene 0.028475
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0284261
PGK1 phosphoglycerate kinase 1 0.0282701
WDR43 WD repeat domain 43 0.0282658

decreased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.146288
COL11A1 collagen, type XI, alpha 1 -0.0948215
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0908662
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.088159
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0879353
CADM2 cell adhesion molecule 2 -0.0825436
GPC3 glypican 3 -0.0731005
PCDH9 protocadherin 9 -0.0646738
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0638624
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0615956
PCLO piccolo presynaptic cytomatrix protein -0.0606017
TMSB10 thymosin beta 10 -0.0601167
RAD51B RAD51 paralog B -0.0573318
VIM vimentin -0.0565709
ADGRL2 adhesion G protein-coupled receptor L2 -0.0559809
RPS16 ribosomal protein S16 -0.0558775
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0502542
LRRC4C leucine rich repeat containing 4C -0.048695
MPG N-methylpurine-DNA glycosylase -0.047804
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0467253
FOXP2 forkhead box P2 -0.0435375
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0434862
SLIT2 slit homolog 2 (Drosophila) -0.0434062
TTC28 tetratricopeptide repeat domain 28 -0.0414461
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0401338
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0398209
PLPP1 phospholipid phosphatase 1 -0.0395846
FTL ferritin, light polypeptide -0.0392432
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0355185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0353376
MDK midkine (neurite growth-promoting factor 2) -0.0340195
TPT1 tumor protein, translationally-controlled 1 -0.0330796
NRG1 neuregulin 1 -0.0320815
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0311843
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0308552
RPS8 ribosomal protein S8 -0.0307142
SYT1 synaptotagmin I -0.0299353
ANKRD12 ankyrin repeat domain 12 -0.0297382
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0295925
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0294531
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0289166
RNF13 ring finger protein 13 -0.0288588
TENM3 teneurin transmembrane protein 3 -0.0278231
SRP54 signal recognition particle 54kDa -0.0275659
RPL35A ribosomal protein L35a -0.0273807
MBD5 methyl-CpG binding domain protein 5 -0.0273265
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0269365
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0268998
STRN3 striatin, calmodulin binding protein 3 -0.0264625
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0264594
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0263464
LATS2 large tumor suppressor kinase 2 -0.0258005
KIAA1328 KIAA1328 -0.0254275
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0253501
ZFPM2 zinc finger protein, FOG family member 2 -0.0253186
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0246921
PARD3B par-3 family cell polarity regulator beta -0.0246884
RPS27A ribosomal protein S27a -0.0239612
PCDH7 protocadherin 7 -0.0235708
TENM2 teneurin transmembrane protein 2 -0.0234733
FAM177A1 family with sequence similarity 177, member A1 -0.0233491
NBEAL1 neurobeachin-like 1 -0.0232865
RPL37 ribosomal protein L37 -0.0231872
RPL31 ribosomal protein L31 -0.0231748
SOX5 SRY (sex determining region Y)-box 5 -0.0231153
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0229747
BBX bobby sox homolog (Drosophila) -0.0229638
SPAG9 sperm associated antigen 9 -0.0227906
TAS2R14 taste receptor, type 2, member 14 -0.0227407
INTS6 integrator complex subunit 6 -0.0226637
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0224509
FRY furry homolog (Drosophila) -0.022401
ZBTB20 zinc finger and BTB domain containing 20 -0.0223655
FAF1 Fas (TNFRSF6) associated factor 1 -0.022203
BRWD1 bromodomain and WD repeat domain containing 1 -0.022192
FNDC3A fibronectin type III domain containing 3A -0.0221276
PSPC1 paraspeckle component 1 -0.0219749
NFIA nuclear factor I/A -0.0218403
PATJ PATJ crumbs cell polarity complex component -0.0218339
HDAC8 histone deacetylase 8 -0.0217749
RPL9 ribosomal protein L9 -0.0217723
SIK2 salt-inducible kinase 2 -0.021722
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0216958
CDH19 cadherin 19, type 2 -0.0215145
DIPK1A divergent protein kinase domain 1A -0.0215109
PRRC2B proline-rich coiled-coil 2B -0.0214974
ANK2 ankyrin 2, neuronal -0.0214565
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0214218
MEIS2 Meis homeobox 2 -0.02132
MAP4 microtubule-associated protein 4 -0.021235
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0212262
DENND1A DENN/MADD domain containing 1A -0.0210105
BCAS3 breast carcinoma amplified sequence 3 -0.0209243
JMJD1C jumonji domain containing 1C -0.0207673
RPS19 ribosomal protein S19 -0.0207603
GPATCH8 G patch domain containing 8 -0.0205083
RPL26 ribosomal protein L26 -0.0204738
RPL36A ribosomal protein L36a -0.0203892
UTRN utrophin -0.020318
MAML2 mastermind-like 2 (Drosophila) -0.0202073