Sildenafil_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sildenafil perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sildenafil_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0911447
EZR ezrin 0.0900288
RBM39 RNA binding motif protein 39 0.0812766
RTN4 reticulon 4 0.0800377
GOLGA4 golgin A4 0.0778929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.077719
TXNRD1 thioredoxin reductase 1 0.0734886
ZNF292 zinc finger protein 292 0.0719167
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0701958
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0660033
ZFAND3 zinc finger, AN1-type domain 3 0.0653363
CAMTA1 calmodulin binding transcription activator 1 0.0642551
NAMPT nicotinamide phosphoribosyltransferase 0.0637245
FLNB filamin B, beta 0.0636097
KDM3A lysine (K)-specific demethylase 3A 0.0588663
ADAM10 ADAM metallopeptidase domain 10 0.0578529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0576066
EXT1 exostosin glycosyltransferase 1 0.0559706
PDE4D phosphodiesterase 4D, cAMP-specific 0.0555765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0555244
EML4 echinoderm microtubule associated protein like 4 0.0548123
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0532187
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0528624
ECT2 epithelial cell transforming 2 0.0512382
LPP LIM domain containing preferred translocation partner in lipoma 0.0509143
KMT2E lysine (K)-specific methyltransferase 2E 0.0504765
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0502923
RNF145 ring finger protein 145 0.0501501
DSCAM Down syndrome cell adhesion molecule 0.0500436
SSBP2 single-stranded DNA binding protein 2 0.0495603
QKI QKI, KH domain containing, RNA binding 0.0492755
ZEB1 zinc finger E-box binding homeobox 1 0.0487462
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0482676
ELOVL5 ELOVL fatty acid elongase 5 0.0482198
NBAS neuroblastoma amplified sequence 0.0471823
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0461117
PDGFC platelet derived growth factor C 0.0453283
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0440056
KDM6A lysine (K)-specific demethylase 6A 0.0427521
TFG TRK-fused gene 0.0424763
CCNL1 cyclin L1 0.0424569
GARS1 glycyl-tRNA synthetase 1 0.0419955
ANK2 ankyrin 2, neuronal 0.041791
PTK2 protein tyrosine kinase 2 0.0414995
PICALM phosphatidylinositol binding clathrin assembly protein 0.0414983
TBC1D5 TBC1 domain family, member 5 0.0414759
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.040921
BRWD1 bromodomain and WD repeat domain containing 1 0.0398525
NCKAP1 NCK-associated protein 1 0.0397211
MED13L mediator complex subunit 13-like 0.039674
PUM2 pumilio RNA-binding family member 2 0.0396178
PYGB phosphorylase, glycogen; brain 0.0388218
GSK3B glycogen synthase kinase 3 beta 0.0382611
COG5 component of oligomeric golgi complex 5 0.0379363
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.037768
MATR3 matrin 3 0.0377634
JMJD1C jumonji domain containing 1C 0.0376657
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0372443
TMEM41B transmembrane protein 41B 0.0369221
TGFBR3 transforming growth factor, beta receptor III 0.0363667
BIRC6 baculoviral IAP repeat containing 6 0.0355392
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0355058
FBXO11 F-box protein 11 0.035301
WDR43 WD repeat domain 43 0.0352182
ZCCHC7 zinc finger, CCHC domain containing 7 0.0341665
PTBP2 polypyrimidine tract binding protein 2 0.0340924
RAB1A RAB1A, member RAS oncogene family 0.0340312
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0337824
ANKRD11 ankyrin repeat domain 11 0.0336733
TMEM39A transmembrane protein 39A 0.0332818
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0332722
NUP58 nucleoporin 58 0.0331102
ASXL1 additional sex combs like transcriptional regulator 1 0.0330604
APP amyloid beta (A4) precursor protein 0.0328794
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0325443
PRELID2 PRELI domain containing 2 0.0324673
FXR1 fragile X mental retardation, autosomal homolog 1 0.0324008
YAP1 Yes-associated protein 1 0.0314514
PNISR PNN-interacting serine/arginine-rich protein 0.0314312
BCLAF1 BCL2-associated transcription factor 1 0.031244
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0309889
PUM1 pumilio RNA-binding family member 1 0.0303385
CDC73 cell division cycle 73 0.0302651
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0301398
SOX6 SRY (sex determining region Y)-box 6 0.0299579
SLMAP sarcolemma associated protein 0.0299171
ZC3H11A zinc finger CCCH-type containing 11A 0.0297692
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0295691
ADAM9 ADAM metallopeptidase domain 9 0.0295678
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0295207
FNDC3B fibronectin type III domain containing 3B 0.0294853
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0294467
SRSF1 serine/arginine-rich splicing factor 1 0.0293117
CRY1 cryptochrome circadian clock 1 0.0292191
CALU calumenin 0.0291986
MSI2 musashi RNA-binding protein 2 0.0291316
TMEM65 transmembrane protein 65 0.0291065
EIF4A2 eukaryotic translation initiation factor 4A2 0.0289657
TTC3 tetratricopeptide repeat domain 3 0.0289405
ZMYM2 zinc finger, MYM-type 2 0.0289031

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.124029
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0850045
BMP10 bone morphogenetic protein 10 -0.0745645
RPS6 ribosomal protein S6 -0.0730384
TPT1 tumor protein, translationally-controlled 1 -0.0692689
RPL35A ribosomal protein L35a -0.0641108
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0623315
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0603327
RPS8 ribosomal protein S8 -0.0495198
RPL31 ribosomal protein L31 -0.0430419
RPL34 ribosomal protein L34 -0.04128
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0397556
RPL19 ribosomal protein L19 -0.0389042
RPLP1 ribosomal protein, large, P1 -0.0379521
MKI67 marker of proliferation Ki-67 -0.0368373
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355605
RPLP2 ribosomal protein, large, P2 -0.0354611
PDE4B phosphodiesterase 4B, cAMP-specific -0.0345671
RPL26 ribosomal protein L26 -0.0336601
RPLP0 ribosomal protein, large, P0 -0.0322802
RPL37A ribosomal protein L37a -0.03112
HSPB1 heat shock 27kDa protein 1 -0.0300908
RPL12 ribosomal protein L12 -0.0298454
RPL9 ribosomal protein L9 -0.0279367
RPL7A ribosomal protein L7a -0.0277463
RPS27A ribosomal protein S27a -0.0275405
RPS3 ribosomal protein S3 -0.0270142
RPL36 ribosomal protein L36 -0.0265281
ACTG1 actin gamma 1 -0.0259379
RPS13 ribosomal protein S13 -0.0251893
RPL23 ribosomal protein L23 -0.0248983
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0248398
FTL ferritin, light polypeptide -0.0245587
CUX1 cut-like homeobox 1 -0.0241403
NAV2 neuron navigator 2 -0.0241353
RPS12 ribosomal protein S12 -0.0238584
RPS19 ribosomal protein S19 -0.0238132
RPL8 ribosomal protein L8 -0.0230501
RPS14 ribosomal protein S14 -0.0229685
S100A4 S100 calcium binding protein A4 -0.0227087
RPS27 ribosomal protein S27 -0.0224388
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0224262
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0217961
RPS17 ribosomal protein S17 -0.0213299
RPL27A ribosomal protein L27a -0.0210759
IFITM3 interferon induced transmembrane protein 3 -0.0208872
TMSB10 thymosin beta 10 -0.0207614
RACK1 receptor for activated C kinase 1 -0.0201203
DIAPH3 diaphanous-related formin 3 -0.0195777
S100A9 S100 calcium binding protein A9 -0.0194162
ZNF438 zinc finger protein 438 -0.0191763
RPS25 ribosomal protein S25 -0.019156
RPL30 ribosomal protein L30 -0.0190579
POTEF POTE ankyrin domain family, member F -0.0188545
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0187187
RPL38 ribosomal protein L38 -0.0185176
FOXP1 forkhead box P1 -0.0183207
PRSS23 protease, serine, 23 -0.0181406
TUBB4B tubulin, beta 4B class IVb -0.0181121
PDE7B phosphodiesterase 7B -0.0179764
PFN1 profilin 1 -0.0179416
S100A6 S100 calcium binding protein A6 -0.0179286
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0177159
RPL11 ribosomal protein L11 -0.017365
RPS21 ribosomal protein S21 -0.0172404
SDK1 sidekick cell adhesion molecule 1 -0.0170319
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0168917
RPS24 ribosomal protein S24 -0.0166176
RPL28 ribosomal protein L28 -0.0165175
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0164764
RPS5 ribosomal protein S5 -0.0161218
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0157736
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0157326
SMC4 structural maintenance of chromosomes 4 -0.0156368
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.015636
RPL32 ribosomal protein L32 -0.0155338
RPL36A ribosomal protein L36a -0.0153835
SEPTIN9 septin 9 -0.0153521
MYO5C myosin VC -0.0153502
GLI3 GLI family zinc finger 3 -0.0153065
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0149783
MACROD2 MACRO domain containing 2 -0.0148961
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0147704
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0147703
RFC3 replication factor C (activator 1) 3, 38kDa -0.0147174
EMP3 epithelial membrane protein 3 -0.0145731
RPS23 ribosomal protein S23 -0.0145148
ITGA10 integrin, alpha 10 -0.0144396
GNAS GNAS complex locus -0.0144221
RPL37 ribosomal protein L37 -0.0144006
RPS11 ribosomal protein S11 -0.0143153
RPS16 ribosomal protein S16 -0.0140159
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0140001
MT2A metallothionein 2A -0.0138738
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0138422
IRS1 insulin receptor substrate 1 -0.0134975
HJURP Holliday junction recognition protein -0.0134118
RPS15 ribosomal protein S15 -0.0133099
RPL18 ribosomal protein L18 -0.0131457
RPS28 ribosomal protein S28 -0.0130335