| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sildenafil_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.147572 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127948 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.109775 |
| PDE10A | phosphodiesterase 10A | 0.0990753 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0981028 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.097217 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0818776 |
| CADM1 | cell adhesion molecule 1 | 0.0795108 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.077308 |
| FNIP1 | folliculin interacting protein 1 | 0.0726693 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0674161 |
| MSN | moesin | 0.0673379 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0638168 |
| DST | dystonin | 0.0618521 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0610072 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0595988 |
| GOLGA4 | golgin A4 | 0.0591513 |
| HELZ | helicase with zinc finger | 0.0580673 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.057909 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0564941 |
| HDAC9 | histone deacetylase 9 | 0.0561184 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0557868 |
| FMNL2 | formin-like 2 | 0.055338 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0550535 |
| NAV2 | neuron navigator 2 | 0.0536192 |
| CDH13 | cadherin 13 | 0.052876 |
| JMJD1C | jumonji domain containing 1C | 0.0519095 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.048571 |
| ATP13A3 | ATPase type 13A3 | 0.0484089 |
| SNX9 | sorting nexin 9 | 0.0481852 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.047563 |
| FLNB | filamin B, beta | 0.0469627 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0459138 |
| ZNF292 | zinc finger protein 292 | 0.0457127 |
| SFTPA2 | surfactant protein A2 | 0.0454096 |
| NDRG1 | N-myc downstream regulated 1 | 0.0444656 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0443922 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0440333 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0437031 |
| OPTN | optineurin | 0.0436531 |
| APP | amyloid beta (A4) precursor protein | 0.0429492 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0426496 |
| ADM | adrenomedullin | 0.0425912 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0424386 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.042374 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0423296 |
| VEGFA | vascular endothelial growth factor A | 0.0423026 |
| OGA | O-GlcNAcase | 0.0416179 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0413443 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0412547 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0407111 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0399685 |
| CALR | calreticulin | 0.0393645 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0389282 |
| PCBP2 | poly(rC) binding protein 2 | 0.0387193 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0380578 |
| RBM39 | RNA binding motif protein 39 | 0.0371535 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0370586 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370439 |
| RND3 | Rho family GTPase 3 | 0.0368779 |
| YEATS2 | YEATS domain containing 2 | 0.0366627 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0365895 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0362428 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0358289 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0351829 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0349216 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0346504 |
| PLIN2 | perilipin 2 | 0.0343844 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0342597 |
| CANX | calnexin | 0.0333355 |
| SETD5 | SET domain containing 5 | 0.0332323 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0329914 |
| DUSP10 | dual specificity phosphatase 10 | 0.0328643 |
| SEPTIN9 | septin 9 | 0.0324981 |
| AFF4 | AF4/FMR2 family, member 4 | 0.032353 |
| RAB7A | RAB7A, member RAS oncogene family | 0.032194 |
| NEK6 | NIMA-related kinase 6 | 0.0320558 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0319792 |
| MYOF | myoferlin | 0.0316657 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0314927 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0313952 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.031279 |
| CCNL1 | cyclin L1 | 0.0312253 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0310792 |
| ERBIN | erbb2 interacting protein | 0.0309516 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0306794 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0303098 |
| ENO1 | enolase 1, (alpha) | 0.030227 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0302216 |
| MMP12 | matrix metallopeptidase 12 | 0.0299849 |
| MYO10 | myosin X | 0.0298213 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0297065 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0295706 |
| FAM219A | family with sequence similarity 219, member A | 0.0295518 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0295507 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0295167 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0294366 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0290115 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0288428 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0285904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BICC1 | BicC family RNA binding protein 1 | -0.11919 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.106699 |
| TMSB10 | thymosin beta 10 | -0.0962371 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0905532 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0842569 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0785969 |
| HLA-B | major histocompatibility complex, class I, B | -0.0665262 |
| FN1 | fibronectin 1 | -0.063125 |
| VCL | vinculin | -0.0618608 |
| MT2A | metallothionein 2A | -0.0539683 |
| RPS24 | ribosomal protein S24 | -0.0482173 |
| RPL23 | ribosomal protein L23 | -0.0464026 |
| RPL35A | ribosomal protein L35a | -0.0461221 |
| OSMR | oncostatin M receptor | -0.045798 |
| FTL | ferritin, light polypeptide | -0.0455917 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0407517 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0402944 |
| RPLP2 | ribosomal protein, large, P2 | -0.0402696 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0400464 |
| KLF6 | Kruppel-like factor 6 | -0.0399602 |
| IER3 | immediate early response 3 | -0.0392811 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0390461 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0383324 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0374401 |
| NABP1 | nucleic acid binding protein 1 | -0.0373192 |
| GNAS | GNAS complex locus | -0.0366157 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0363963 |
| RPL37A | ribosomal protein L37a | -0.0358202 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0355607 |
| MKI67 | marker of proliferation Ki-67 | -0.0342339 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.034022 |
| COL1A1 | collagen, type I, alpha 1 | -0.0337724 |
| FRMD4A | FERM domain containing 4A | -0.0335381 |
| RPS19 | ribosomal protein S19 | -0.0334209 |
| RIGI | RNA sensor RIG-I | -0.0333379 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0329201 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0326584 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0322323 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321853 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.031996 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0309778 |
| CD44 | CD44 molecule (Indian blood group) | -0.0309308 |
| PALLD | palladin, cytoskeletal associated protein | -0.0304267 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0294891 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0292993 |
| THBS1 | thrombospondin 1 | -0.0291122 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0273755 |
| RPL26 | ribosomal protein L26 | -0.0266875 |
| RPS21 | ribosomal protein S21 | -0.0266132 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0260722 |
| CENPF | centromere protein F, 350/400kDa | -0.0259073 |
| HDAC8 | histone deacetylase 8 | -0.0255202 |
| RPL19 | ribosomal protein L19 | -0.0249382 |
| RPL34 | ribosomal protein L34 | -0.0249189 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0248621 |
| THBS2 | thrombospondin 2 | -0.0247469 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.023801 |
| CLIC4 | chloride intracellular channel 4 | -0.0236602 |
| SLC38A1 | solute carrier family 38, member 1 | -0.023586 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0232871 |
| AHNAK | AHNAK nucleoprotein | -0.0232421 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0231928 |
| CENPE | centromere protein E, 312kDa | -0.023124 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0231168 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0230992 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0230145 |
| TGFB2 | transforming growth factor, beta 2 | -0.0230104 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0229765 |
| TUBB | tubulin, beta class I | -0.0228999 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0226075 |
| RPL36A | ribosomal protein L36a | -0.0220361 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0217196 |
| RPL38 | ribosomal protein L38 | -0.0209469 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0209029 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0208475 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0208314 |
| RTN4 | reticulon 4 | -0.0207581 |
| RRBP1 | ribosome binding protein 1 | -0.0207179 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0206915 |
| RPS28 | ribosomal protein S28 | -0.0205085 |
| SYAP1 | synapse associated protein 1 | -0.0203706 |
| MT1X | metallothionein 1X | -0.0203008 |
| B2M | beta-2-microglobulin | -0.0197613 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0197349 |
| RPL9 | ribosomal protein L9 | -0.0196605 |
| RPLP0 | ribosomal protein, large, P0 | -0.0196016 |
| MX1 | MX dynamin-like GTPase 1 | -0.0195771 |
| RPL36 | ribosomal protein L36 | -0.0195721 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0193597 |
| RPL32 | ribosomal protein L32 | -0.0192544 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0190772 |
| COL1A2 | collagen, type I, alpha 2 | -0.018958 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0185732 |
| RPL35 | ribosomal protein L35 | -0.0183744 |
| TMSB4X | thymosin beta 4, X-linked | -0.0182548 |
| STK17A | serine/threonine kinase 17a | -0.0182177 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0181099 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0179576 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0177703 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0176591 |
