| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sildenafil_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.102016 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.098724 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0873805 |
| NRXN3 | neurexin 3 | 0.086485 |
| CDH13 | cadherin 13 | 0.0721853 |
| EGFR | epidermal growth factor receptor | 0.0698245 |
| ATP13A3 | ATPase type 13A3 | 0.0694639 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0598347 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0594895 |
| GRB10 | growth factor receptor-bound protein 10 | 0.058708 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0584787 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0583674 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0582244 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.057504 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.056504 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.054944 |
| ANXA5 | annexin A5 | 0.0547676 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0532726 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0532347 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0522341 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0515517 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0506812 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0505011 |
| FAM13A | family with sequence similarity 13, member A | 0.0498771 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0495132 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0493585 |
| COL1A2 | collagen, type I, alpha 2 | 0.0483441 |
| IL6 | interleukin 6 | 0.0460566 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0447354 |
| RNF145 | ring finger protein 145 | 0.0442788 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0438426 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0431821 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0428267 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0420682 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.041794 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0413777 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0407434 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0402329 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0391119 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0390836 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0387183 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0380879 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0375035 |
| APOL2 | apolipoprotein L, 2 | 0.0365675 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0363358 |
| STC2 | stanniocalcin 2 | 0.0360679 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0358857 |
| AUTS2 | autism susceptibility candidate 2 | 0.0358416 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0356517 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0351693 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0348213 |
| TNS3 | tensin 3 | 0.0347613 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0345394 |
| WTAP | Wilms tumor 1 associated protein | 0.0344246 |
| RASA2 | RAS p21 protein activator 2 | 0.0343227 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0341519 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0331602 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0331487 |
| KAZN | kazrin, periplakin interacting protein | 0.032958 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0325733 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.032347 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0315057 |
| PTK2 | protein tyrosine kinase 2 | 0.0313327 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0311227 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0306452 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.030431 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0303276 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.030253 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0294514 |
| SPAG9 | sperm associated antigen 9 | 0.0293097 |
| SEPTIN9 | septin 9 | 0.0292967 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0291665 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0288212 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.028767 |
| NCKAP1 | NCK-associated protein 1 | 0.0287636 |
| C1D | C1D nuclear receptor corepressor | 0.0285031 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0284433 |
| HELZ | helicase with zinc finger | 0.0284289 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0283348 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0281386 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0281382 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0280828 |
| COPA | coatomer protein complex, subunit alpha | 0.0280667 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0278845 |
| WASF2 | WAS protein family, member 2 | 0.0278549 |
| F11R | F11 receptor | 0.0277737 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0276302 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0275586 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0275362 |
| VIM | vimentin | 0.0275346 |
| FRMD4A | FERM domain containing 4A | 0.02745 |
| LDHA | lactate dehydrogenase A | 0.0272088 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0271388 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0270626 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.0270593 |
| YME1L1 | YME1-like 1 ATPase | 0.0266348 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0263328 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0261847 |
| NAV3 | neuron navigator 3 | 0.0261802 |
| RHOA | ras homolog family member A | 0.0261388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.280656 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.159047 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0795061 |
| B2M | beta-2-microglobulin | -0.0752446 |
| PTMA | prothymosin, alpha | -0.0727208 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0704692 |
| FN1 | fibronectin 1 | -0.0675397 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0658384 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.05514 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0525635 |
| SMYD3 | SET and MYND domain containing 3 | -0.0515408 |
| ANLN | anillin, actin binding protein | -0.0505399 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0503506 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0502991 |
| FTL | ferritin, light polypeptide | -0.048723 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0486708 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.045961 |
| H3-3B | H3.3 histone B | -0.045719 |
| LOX | lysyl oxidase | -0.0452365 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.043334 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0426456 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0419944 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0412308 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.039857 |
| RAD51B | RAD51 paralog B | -0.0396262 |
| MKI67 | marker of proliferation Ki-67 | -0.0388729 |
| PRELID2 | PRELI domain containing 2 | -0.0385392 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0383361 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0380573 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0377845 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0376221 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.037522 |
| DIAPH3 | diaphanous-related formin 3 | -0.0372025 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0369296 |
| HLA-B | major histocompatibility complex, class I, B | -0.036289 |
| RPS5 | ribosomal protein S5 | -0.0350055 |
| PTN | pleiotrophin | -0.0349521 |
| MEF2A | myocyte enhancer factor 2A | -0.0349443 |
| RPL11 | ribosomal protein L11 | -0.034735 |
| RACK1 | receptor for activated C kinase 1 | -0.0342581 |
| RBM6 | RNA binding motif protein 6 | -0.0339016 |
| TMSB10 | thymosin beta 10 | -0.0338744 |
| TMSB4X | thymosin beta 4, X-linked | -0.0336366 |
| MTPN | myotrophin | -0.0335069 |
| RSF1 | remodeling and spacing factor 1 | -0.0334602 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0331291 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0330302 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0330209 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0327292 |
| HMGA2 | high mobility group AT-hook 2 | -0.0325407 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0317684 |
| RPS16 | ribosomal protein S16 | -0.0317249 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0317005 |
| GNAS | GNAS complex locus | -0.0316192 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0314391 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | -0.0312199 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0308479 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0308064 |
| RPLP2 | ribosomal protein, large, P2 | -0.0306666 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0303537 |
| RPL26 | ribosomal protein L26 | -0.0303183 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0301939 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0301465 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0300299 |
| STC1 | stanniocalcin 1 | -0.0297584 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0294799 |
| RPL35A | ribosomal protein L35a | -0.029399 |
| CKAP2 | cytoskeleton associated protein 2 | -0.029378 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0292962 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.029047 |
| OGA | O-GlcNAcase | -0.0287946 |
| EGR1 | early growth response 1 | -0.0286488 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.0285969 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0284747 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0283488 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0277542 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0277499 |
| PTGES2 | prostaglandin E synthase 2 | -0.0277403 |
| ZNF736 | zinc finger protein 736 | -0.0276745 |
| RPS6 | ribosomal protein S6 | -0.0276043 |
| FNBP1 | formin binding protein 1 | -0.0274574 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0274504 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0273616 |
| RPL32 | ribosomal protein L32 | -0.0273142 |
| MAP1B | microtubule-associated protein 1B | -0.0273135 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0273026 |
| FUS | FUS RNA binding protein | -0.0271842 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0271358 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.027057 |
| UBXN4 | UBX domain protein 4 | -0.0268812 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0268314 |
| HMGB1 | high mobility group box 1 | -0.0267503 |
| TXNIP | thioredoxin interacting protein | -0.0266665 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0266327 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0264508 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0264218 |
| KIF5B | kinesin family member 5B | -0.0261321 |
| ACTG1 | actin gamma 1 | -0.0261147 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0260859 |
| HMGB2 | high mobility group box 2 | -0.0257913 |
