| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sildenafil_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TBC1D5 | TBC1 domain family, member 5 | 0.0718259 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0705184 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0614474 |
| PRKCA | protein kinase C, alpha | 0.0572749 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0568877 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0555084 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.051314 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0478297 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0433536 |
| ZNF292 | zinc finger protein 292 | 0.0430005 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0424323 |
| PYGL | phosphorylase, glycogen, liver | 0.04202 |
| ATXN1 | ataxin 1 | 0.0404779 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0402776 |
| PHF21A | PHD finger protein 21A | 0.0398621 |
| SRPK2 | SRSF protein kinase 2 | 0.0393128 |
| ANLN | anillin, actin binding protein | 0.0386345 |
| ASPH | aspartate beta-hydroxylase | 0.0385764 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0376674 |
| MATR3 | matrin 3 | 0.0375553 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370822 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.036475 |
| PARD3 | par-3 family cell polarity regulator | 0.0356522 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0344401 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0336675 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0319047 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0318471 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0316814 |
| SEPTIN9 | septin 9 | 0.0316023 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0312312 |
| NUP153 | nucleoporin 153kDa | 0.0307144 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.029401 |
| YAP1 | Yes-associated protein 1 | 0.0293122 |
| PAPOLA | poly(A) polymerase alpha | 0.0291212 |
| ECT2 | epithelial cell transforming 2 | 0.02797 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.027893 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0274843 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0273642 |
| SNX9 | sorting nexin 9 | 0.027083 |
| RNF145 | ring finger protein 145 | 0.0269143 |
| WWOX | WW domain containing oxidoreductase | 0.0266895 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0265787 |
| DST | dystonin | 0.0265475 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.026532 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0265236 |
| NEK6 | NIMA-related kinase 6 | 0.0264719 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0264284 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0260415 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0258013 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0257888 |
| ATG7 | autophagy related 7 | 0.0257148 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0256347 |
| INSIG2 | insulin induced gene 2 | 0.0255971 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0252985 |
| MCL1 | myeloid cell leukemia 1 | 0.0252284 |
| EXOC4 | exocyst complex component 4 | 0.0250482 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.024935 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0248652 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0248527 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0247894 |
| PTK2 | protein tyrosine kinase 2 | 0.0245641 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0243935 |
| CEP250 | centrosomal protein 250kDa | 0.0242849 |
| STK24 | serine/threonine kinase 24 | 0.0242468 |
| ZNF609 | zinc finger protein 609 | 0.0242301 |
| DCP1A | decapping mRNA 1A | 0.0240969 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0239993 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0239686 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0239391 |
| MYO9A | myosin IXA | 0.0238982 |
| TAOK1 | TAO kinase 1 | 0.0237966 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0236542 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0234564 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0234102 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0234023 |
| FAM13A | family with sequence similarity 13, member A | 0.0233298 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0232738 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.023232 |
| TMEM245 | transmembrane protein 245 | 0.0229645 |
| NUP58 | nucleoporin 58 | 0.0228528 |
| HELZ | helicase with zinc finger | 0.0227606 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0227493 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0227239 |
| ACTN1 | actinin, alpha 1 | 0.0227196 |
| COG6 | component of oligomeric golgi complex 6 | 0.0226916 |
| KLC1 | kinesin light chain 1 | 0.0226509 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0224507 |
| AHNAK | AHNAK nucleoprotein | 0.0223606 |
| SLMAP | sarcolemma associated protein | 0.0222135 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0221575 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0220842 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0219068 |
| XPO1 | exportin 1 | 0.0218731 |
| UBQLN1 | ubiquilin 1 | 0.0218633 |
| PHF3 | PHD finger protein 3 | 0.0216365 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0215834 |
| COG5 | component of oligomeric golgi complex 5 | 0.0215708 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0214934 |
| FMNL2 | formin-like 2 | 0.0214778 |
| NBEAL1 | neurobeachin-like 1 | 0.0214662 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.411992 |
| VIM | vimentin | -0.118262 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0956314 |
| TMSB10 | thymosin beta 10 | -0.0676638 |
| RPLP1 | ribosomal protein, large, P1 | -0.0675706 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0651744 |
| RPS6 | ribosomal protein S6 | -0.0620722 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0533676 |
| RPS13 | ribosomal protein S13 | -0.0502511 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0499674 |
| RPL35A | ribosomal protein L35a | -0.0498595 |
| RPS25 | ribosomal protein S25 | -0.0489401 |
| RPL36 | ribosomal protein L36 | -0.0471183 |
| MT2A | metallothionein 2A | -0.046187 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0455663 |
| ACTG1 | actin gamma 1 | -0.0449623 |
| RPLP2 | ribosomal protein, large, P2 | -0.0446206 |
| RPL32 | ribosomal protein L32 | -0.0443232 |
| RPS27A | ribosomal protein S27a | -0.0438908 |
| PTMA | prothymosin, alpha | -0.0435822 |
| RPS17 | ribosomal protein S17 | -0.0432965 |
| UBB | ubiquitin B | -0.0429029 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0420658 |
| RPL23 | ribosomal protein L23 | -0.041614 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0413696 |
| GNAS | GNAS complex locus | -0.0410603 |
| RPL19 | ribosomal protein L19 | -0.0408596 |
| RPS12 | ribosomal protein S12 | -0.0400289 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0399648 |
| OSMR | oncostatin M receptor | -0.0398751 |
| CD44 | CD44 molecule (Indian blood group) | -0.0392289 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0389839 |
| RPS21 | ribosomal protein S21 | -0.0381213 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0376274 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0374412 |
| RPL37 | ribosomal protein L37 | -0.0371224 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0367703 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0367303 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0366843 |
| RPL12 | ribosomal protein L12 | -0.0366642 |
| RPS14 | ribosomal protein S14 | -0.0362808 |
| RPL34 | ribosomal protein L34 | -0.0360732 |
| RPL28 | ribosomal protein L28 | -0.0349926 |
| RPS8 | ribosomal protein S8 | -0.0348522 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0343271 |
| GOLGA4 | golgin A4 | -0.0342641 |
| RPL11 | ribosomal protein L11 | -0.0338037 |
| YBX3 | Y box binding protein 3 | -0.0336434 |
| RPS29 | ribosomal protein S29 | -0.0335572 |
| RPL9 | ribosomal protein L9 | -0.0333472 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0331818 |
| RPL31 | ribosomal protein L31 | -0.0327865 |
| FTL | ferritin, light polypeptide | -0.0324414 |
| LDHA | lactate dehydrogenase A | -0.032323 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0322294 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0322045 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0321381 |
| RPS19 | ribosomal protein S19 | -0.0318934 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0312988 |
| RACK1 | receptor for activated C kinase 1 | -0.0312248 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0307863 |
| RPL35 | ribosomal protein L35 | -0.0306709 |
| H3-3B | H3.3 histone B | -0.0298981 |
| DIAPH3 | diaphanous-related formin 3 | -0.0298842 |
| S100A9 | S100 calcium binding protein A9 | -0.0296617 |
| B2M | beta-2-microglobulin | -0.0288538 |
| RPL26 | ribosomal protein L26 | -0.0286176 |
| RPS28 | ribosomal protein S28 | -0.028563 |
| MKI67 | marker of proliferation Ki-67 | -0.0282605 |
| RPS20 | ribosomal protein S20 | -0.0280688 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0279407 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.027433 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0273602 |
| RPL37A | ribosomal protein L37a | -0.026454 |
| HMGB1 | high mobility group box 1 | -0.0263407 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0263315 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0260442 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0257846 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0256855 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0256463 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0256084 |
| RPS15 | ribosomal protein S15 | -0.0252098 |
| RPL27 | ribosomal protein L27 | -0.0251873 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0251326 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0248344 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.02464 |
| RPLP0 | ribosomal protein, large, P0 | -0.0243569 |
| RSU1 | Ras suppressor protein 1 | -0.0238253 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0235217 |
| RPL15 | ribosomal protein L15 | -0.0234776 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0234708 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0234268 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0233761 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0229771 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0228892 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -0.0228739 |
| RPS3 | ribosomal protein S3 | -0.0228027 |
| RIGI | RNA sensor RIG-I | -0.0226893 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0225592 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.022059 |
