| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sildenafil perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sildenafil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.176967 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.16118 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.131868 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.109509 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0856051 |
| PTK2 | protein tyrosine kinase 2 | 0.0850347 |
| PRRC2C | proline-rich coiled-coil 2C | 0.075556 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0748705 |
| CENPF | centromere protein F, 350/400kDa | 0.0738317 |
| CD109 | CD109 molecule | 0.0689858 |
| GOLGA4 | golgin A4 | 0.0665147 |
| DST | dystonin | 0.0628213 |
| AHR | aryl hydrocarbon receptor | 0.0624212 |
| SMAD3 | SMAD family member 3 | 0.0615973 |
| FAM13A | family with sequence similarity 13, member A | 0.0609537 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.060307 |
| VIM | vimentin | 0.0600235 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0593552 |
| OGA | O-GlcNAcase | 0.0588669 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0564915 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0561592 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0559467 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0538835 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0534248 |
| ZNF292 | zinc finger protein 292 | 0.0534205 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0528774 |
| ASPH | aspartate beta-hydroxylase | 0.0520264 |
| PRELID2 | PRELI domain containing 2 | 0.0497308 |
| MKI67 | marker of proliferation Ki-67 | 0.0488842 |
| RNF145 | ring finger protein 145 | 0.0486834 |
| SMYD3 | SET and MYND domain containing 3 | 0.0484791 |
| FNBP1 | formin binding protein 1 | 0.0483445 |
| HELZ | helicase with zinc finger | 0.0483054 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0475911 |
| AFDN | afadin, adherens junction formation factor | 0.0465944 |
| SUCO | SUN domain containing ossification factor | 0.0463887 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0448392 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0447603 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0446316 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0444811 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0437862 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0434126 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.043095 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0423238 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0422664 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.042116 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0407748 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0407158 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0405042 |
| MATR3 | matrin 3 | 0.039788 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0394793 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0393366 |
| ETV6 | ets variant 6 | 0.0392569 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0384616 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0383736 |
| VEGFC | vascular endothelial growth factor C | 0.0377812 |
| YME1L1 | YME1-like 1 ATPase | 0.0376912 |
| TXNRD1 | thioredoxin reductase 1 | 0.0374518 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0373307 |
| RUNX1 | runt-related transcription factor 1 | 0.0372421 |
| EZR | ezrin | 0.0369518 |
| JMJD1C | jumonji domain containing 1C | 0.0366211 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0363335 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0359207 |
| SLTM | SAFB-like, transcription modulator | 0.0357764 |
| NAV2 | neuron navigator 2 | 0.0355713 |
| RPS6 | ribosomal protein S6 | 0.0354531 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0352624 |
| ITGA1 | integrin, alpha 1 | 0.0352477 |
| RTN4 | reticulon 4 | 0.035146 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0349809 |
| COG5 | component of oligomeric golgi complex 5 | 0.0347268 |
| TPM3 | tropomyosin 3 | 0.0344089 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0339498 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0333518 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0332173 |
| TXNIP | thioredoxin interacting protein | 0.0331218 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0330545 |
| CD44 | CD44 molecule (Indian blood group) | 0.0326615 |
| TPR | translocated promoter region, nuclear basket protein | 0.0322639 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0322524 |
| GPC6 | glypican 6 | 0.0320453 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0319262 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0316534 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0314811 |
| TFG | TRK-fused gene | 0.0311111 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0306094 |
| DIAPH3 | diaphanous-related formin 3 | 0.0305897 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0304784 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.030285 |
| ANLN | anillin, actin binding protein | 0.0302375 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.029965 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0296913 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0296178 |
| RBM39 | RNA binding motif protein 39 | 0.0294832 |
| ZNF638 | zinc finger protein 638 | 0.0294649 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0294167 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0289413 |
| ANO6 | anoctamin 6 | 0.0281821 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0280979 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.257978 |
| NRG1 | neuregulin 1 | -0.253503 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.203073 |
| FN1 | fibronectin 1 | -0.11229 |
| TMSB10 | thymosin beta 10 | -0.0726742 |
| HLA-B | major histocompatibility complex, class I, B | -0.0707049 |
| VCL | vinculin | -0.0642502 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0517862 |
| INTS6 | integrator complex subunit 6 | -0.0510196 |
| HMGA2 | high mobility group AT-hook 2 | -0.050664 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0498644 |
| PALLD | palladin, cytoskeletal associated protein | -0.0471018 |
| AEBP2 | AE binding protein 2 | -0.045966 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0433866 |
| FTL | ferritin, light polypeptide | -0.0426101 |
| SQSTM1 | sequestosome 1 | -0.0409556 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0402951 |
| B2M | beta-2-microglobulin | -0.0355127 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0342277 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0326772 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0316051 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0301279 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0296661 |
| EGR1 | early growth response 1 | -0.0296652 |
| ACTG1 | actin gamma 1 | -0.0290894 |
| NTN4 | netrin 4 | -0.0290303 |
| RAI14 | retinoic acid induced 14 | -0.0279973 |
| CANX | calnexin | -0.0279127 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0278317 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0273696 |
| HLA-A | major histocompatibility complex, class I, A | -0.0268121 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0267459 |
| TMSB4X | thymosin beta 4, X-linked | -0.0263001 |
| S100A6 | S100 calcium binding protein A6 | -0.0261891 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0261115 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0257564 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0253917 |
| RPL31 | ribosomal protein L31 | -0.025303 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0250579 |
| ZNF217 | zinc finger protein 217 | -0.0250233 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0248296 |
| TGFB1 | transforming growth factor, beta 1 | -0.0248178 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0245985 |
| GNAS | GNAS complex locus | -0.0243707 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0238036 |
| MMP13 | matrix metallopeptidase 13 | -0.0234785 |
| LRRC23 | leucine rich repeat containing 23 | -0.0231418 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0222645 |
| TENM4 | teneurin transmembrane protein 4 | -0.0217006 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0216666 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0211093 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0203108 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0202448 |
| DUSP6 | dual specificity phosphatase 6 | -0.0198317 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.019585 |
| STC2 | stanniocalcin 2 | -0.0190773 |
| CCDC138 | coiled-coil domain containing 138 | -0.0187931 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0186652 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0186018 |
| GLCCI1 | glucocorticoid induced 1 | -0.0183668 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0176078 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.017493 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0173858 |
| CD63 | CD63 molecule | -0.0173452 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0173074 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0172755 |
| CP | ceruloplasmin (ferroxidase) | -0.0168002 |
| ACOXL | acyl-CoA oxidase-like | -0.0167247 |
| PPARA | peroxisome proliferator-activated receptor alpha | -0.0167171 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0167117 |
| IL6 | interleukin 6 | -0.0166187 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0164577 |
| PTMA | prothymosin, alpha | -0.0163932 |
| BMERB1 | bMERB domain containing 1 | -0.0162084 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.016132 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0160875 |
| LAMB3 | laminin, beta 3 | -0.0160686 |
| CADM2 | cell adhesion molecule 2 | -0.0160419 |
| RAB10 | RAB10, member RAS oncogene family | -0.0160085 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0159318 |
| RBM47 | RNA binding motif protein 47 | -0.0158807 |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 | -0.0158597 |
| MT2A | metallothionein 2A | -0.0158394 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0153694 |
| MORF4L2 | mortality factor 4 like 2 | -0.0153491 |
| CTSD | cathepsin D | -0.0152883 |
| RNF220 | ring finger protein 220 | -0.0152246 |
| JUN | jun proto-oncogene | -0.0151829 |
| FAM20C | family with sequence similarity 20, member C | -0.0150103 |
| TMEM178B | transmembrane protein 178B | -0.0150077 |
| POU2F2 | POU class 2 homeobox 2 | -0.0149686 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0148941 |
| RPL35A | ribosomal protein L35a | -0.0148927 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0148328 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0145843 |
| RTN3 | reticulon 3 | -0.0144472 |
| RSU1 | Ras suppressor protein 1 | -0.0143927 |
| UBAP2 | ubiquitin associated protein 2 | -0.0143282 |
| RPS28 | ribosomal protein S28 | -0.014286 |
| RPL23 | ribosomal protein L23 | -0.014199 |
