Silicosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. (Human Disease Ontology, DOID_10325)
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Genes

336 genes co-occuring with the disease Silicosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TGFB1 transforming growth factor, beta 1 2.66
IL1B interleukin 1, beta 2.649
ZC3H4 zinc finger CCCH-type containing 4 2.486
TNF tumor necrosis factor 2.484
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.48
NLRP3 NLR family, pyrin domain containing 3 2.431
IL6 interleukin 6 2.331
IL18 interleukin 18 2.327
IFNG interferon, gamma 2.192
IL1A interleukin 1, alpha 2.131
FN1 fibronectin 1 2.112
IL10 interleukin 10 2.055
CD4 CD4 molecule 2.055
SMAD3 SMAD family member 3 2.038
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.037
IL4 interleukin 4 2.009
SMAD2 SMAD family member 2 2.002
CCL2 chemokine (C-C motif) ligand 2 1.99
IL13 interleukin 13 1.973
CTSB cathepsin B 1.965
MARCO macrophage receptor with collagenous structure 1.948
AIM2 absent in melanoma 2 1.943
IL17A interleukin 17A 1.938
ZC3H12A zinc finger CCCH-type containing 12A 1.929
TLR4 toll-like receptor 4 1.917
CXCL8 chemokine (C-X-C motif) ligand 8 1.893
NLRC4 NLR family, CARD domain containing 4 1.891
PYCARD PYD and CARD domain containing 1.853
FAM13A family with sequence similarity 13, member A 1.849
MYD88 myeloid differentiation primary response 88 1.846
SMAD7 SMAD family member 7 1.815
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.794
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 1.782
SFTPC surfactant protein C 1.778
HMOX1 heme oxygenase 1 1.772
ZNF740 zinc finger protein 740 1.772
CD8A CD8a molecule 1.765
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.761
MMP9 matrix metallopeptidase 9 1.76
NLRP1 NLR family, pyrin domain containing 1 1.756
CCN2 cellular communication network factor 2 1.744
ACE angiotensin I converting enzyme 1.743
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.728
GSDMD gasdermin D 1.728
IL1R1 interleukin 1 receptor, type I 1.719
PPP1R13B protein phosphatase 1, regulatory subunit 13B 1.718
IL5 interleukin 5 1.715
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.699
TIMP1 TIMP metallopeptidase inhibitor 1 1.693
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.69
CTSS cathepsin S 1.687
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.685
COL1A1 collagen, type I, alpha 1 1.682
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.679
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 1.676
ALB albumin 1.665
FASLG Fas ligand (TNF superfamily, member 6) 1.664
CGAS cyclic GMP-AMP synthase 1.662
BCL2 B-cell CLL/lymphoma 2 1.658
CCL3 chemokine (C-C motif) ligand 3 1.654
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.653
BECN1 beclin 1, autophagy related 1.649
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.645
SFTPD surfactant protein D 1.636
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.634
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.627
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.621
SEC14L3 SEC14-like 3 (S. cerevisiae) 1.609
MMP12 matrix metallopeptidase 12 1.609
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.588
HMGB1 high mobility group box 1 1.586
SPP1 secreted phosphoprotein 1 1.576
IL33 interleukin 33 1.575
NPNT nephronectin 1.573
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.563
MMP2 matrix metallopeptidase 2 1.563
TLR2 toll-like receptor 2 1.561
ACTB actin, beta 1.56
CRP C-reactive protein, pentraxin-related 1.56
MRC1 mannose receptor, C type 1 1.557
CD68 CD68 molecule 1.556
IL2 interleukin 2 1.555
CXCL10 chemokine (C-X-C motif) ligand 10 1.553
GPX3 glutathione peroxidase 3 1.551
PANX1 pannexin 1 1.541
TXNIP thioredoxin interacting protein 1.535
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.529
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.52
FOXP3 forkhead box P3 1.519
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.518
COL3A1 collagen, type III, alpha 1 1.516
MPO myeloperoxidase 1.505
PRTN3 proteinase 3 1.505
GPX2 glutathione peroxidase 2 1.504
GPX6 glutathione peroxidase 6 1.5
GPX8 glutathione peroxidase 8 (putative) 1.499
GPX5 glutathione peroxidase 5 1.499
JUN jun proto-oncogene 1.496
GPX7 glutathione peroxidase 7 1.496
TP53 tumor protein p53 1.477
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.475
NOX4 NADPH oxidase 4 1.47
SCARB1 scavenger receptor class B, member 1 1.463
NEK7 NIMA-related kinase 7 1.461
SNAI1 snail family zinc finger 1 1.453
ELANE elastase, neutrophil expressed 1.445
NFE2L2 nuclear factor, erythroid 2-like 2 1.441
NLRP6 NLR family, pyrin domain containing 6 1.439
ARG1 arginase 1 1.431
FGF2 fibroblast growth factor 2 (basic) 1.429
IL1RN interleukin 1 receptor antagonist 1.426
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.421
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.419
CYBB cytochrome b-245, beta polypeptide 1.417
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.416
IFNB1 interferon, beta 1, fibroblast 1.413
FAS Fas cell surface death receptor 1.413
MAPK3 mitogen-activated protein kinase 3 1.412
MUC1 mucin 1, cell surface associated 1.407
PTPRC protein tyrosine phosphatase, receptor type, C 1.405
NLRP12 NLR family, pyrin domain containing 12 1.404
PXDNL peroxidasin-like 1.404
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.404
PXDN peroxidasin 1.402
MSR1 macrophage scavenger receptor 1 1.4
BAX BCL2-associated X protein 1.394
IRF3 interferon regulatory factor 3 1.383
TLR9 toll-like receptor 9 1.376
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.375
STAT1 signal transducer and activator of transcription 1, 91kDa 1.373
SCARB2 scavenger receptor class B, member 2 1.372
CCR2 chemokine (C-C motif) receptor 2 1.37
CCL5 chemokine (C-C motif) ligand 5 1.365
ATAT1 alpha tubulin acetyltransferase 1 1.362
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.358
CD36 CD36 molecule (thrombospondin receptor) 1.351
CYCS cytochrome c, somatic 1.347
BMP7 bone morphogenetic protein 7 1.346
R3HDM4 R3H domain containing 4 1.345
ACE2 angiotensin I converting enzyme 2 1.342
ATG5 autophagy related 5 1.336
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.334
TGFBR1 transforming growth factor, beta receptor 1 1.333
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.332
SQSTM1 sequestosome 1 1.328
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.327
NLRP7 NLR family, pyrin domain containing 7 1.325
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.324
TADA2A transcriptional adaptor 2A 1.321
ANKRD42 ankyrin repeat domain 42 1.32
PPARG peroxisome proliferator-activated receptor gamma 1.316
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.316
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.315
IL9 interleukin 9 1.314
CAV1 caveolin 1, caveolae protein, 22kDa 1.309
ICAM1 intercellular adhesion molecule 1 1.309
CD163 CD163 molecule 1.308
PINK1 PTEN induced putative kinase 1 1.305
TXN thioredoxin 1.298
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.292
MAP1A microtubule-associated protein 1A 1.291
CCL4 chemokine (C-C motif) ligand 4 1.29
NOD2 nucleotide-binding oligomerization domain containing 2 1.29
TLR3 toll-like receptor 3 1.289
FGF7 fibroblast growth factor 7 1.286
CCL11 chemokine (C-C motif) ligand 11 1.282
NAIP NLR family, apoptosis inhibitory protein 1.281
CXCL2 chemokine (C-X-C motif) ligand 2 1.277
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.275
MEFV Mediterranean fever 1.275
IFI16 interferon, gamma-inducible protein 16 1.275
CARD18 caspase recruitment domain family, member 18 1.269
ELN elastin 1.269
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.268
SMIM19 small integral membrane protein 19 1.262
CENPB centromere protein B, 80kDa 1.26
OCSTAMP osteoclast stimulatory transmembrane protein 1.258
MMP1 matrix metallopeptidase 1 1.251
COL1A2 collagen, type I, alpha 2 1.25
CFAP73 cilia and flagella associated protein 73 1.246
LGALS3 lectin, galactoside-binding, soluble, 3 1.242
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.234
RIOX2 ribosomal oxygenase 2 1.233
CD86 CD86 molecule 1.228
IL22 interleukin 22 1.227
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.226
RHOA ras homolog family member A 1.225
ZEB1 zinc finger E-box binding homeobox 1 1.221
TUB tubby bipartite transcription factor 1.219
KEAP1 kelch-like ECH-associated protein 1 1.218
NLRP4 NLR family, pyrin domain containing 4 1.218
ZNF416 zinc finger protein 416 1.217
PYURF PIGY upstream reading frame 1.217
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.216
TOLLIP toll interacting protein 1.216
GSDMA gasdermin A 1.216
CYBA cytochrome b-245, alpha polypeptide 1.216
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.212
SYK spleen tyrosine kinase 1.209
MLKL mixed lineage kinase domain-like 1.207
GSK3B glycogen synthase kinase 3 beta 1.207
TBK1 TANK-binding kinase 1 1.204
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.203
FOXK2 forkhead box K2 1.199
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.195
AGER advanced glycosylation end product-specific receptor 1.188
SMAD4 SMAD family member 4 1.188
EGFR epidermal growth factor receptor 1.18
JAK2 Janus kinase 2 1.18
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.179
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.179
MAPK8 mitogen-activated protein kinase 8 1.17
ANXA1 annexin A1 1.166
CHIT1 chitinase 1 (chitotriosidase) 1.163
SFTPA2 surfactant protein A2 1.162
THY1 Thy-1 cell surface antigen 1.16
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.154
STING1 stimulator of interferon response cGAMP interactor 1 1.153
CFAP157 cilia and flagella associated protein 157 1.151
IL17F interleukin 17F 1.147
CCND1 cyclin D1 1.143
FGF10 fibroblast growth factor 10 1.143
AGTR2 angiotensin II receptor, type 2 1.141
ARG2 arginase 2 1.139
NCF1 neutrophil cytosolic factor 1 1.139
PTEN phosphatase and tensin homolog 1.134
FGF13 fibroblast growth factor 13 1.134
ANXA5 annexin A5 1.134
SIRT1 sirtuin 1 1.131
BBC3 BCL2 binding component 3 1.131
CSF1 colony stimulating factor 1 (macrophage) 1.128
ESX1 ESX homeobox 1 1.128
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 1.127
GATA3 GATA binding protein 3 1.126
CD44 CD44 molecule (Indian blood group) 1.126
EGF epidermal growth factor 1.122
CCK cholecystokinin 1.122
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.121
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.119
GREM1 gremlin 1, DAN family BMP antagonist 1.119
CXCL12 chemokine (C-X-C motif) ligand 12 1.119
CD80 CD80 molecule 1.119
CD63 CD63 molecule 1.117
BCL2L1 BCL2-like 1 1.107
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.106
RETNLB resistin like beta 1.106
SFTPB surfactant protein B 1.106
EGR1 early growth response 1 1.104
TLR7 toll-like receptor 7 1.103
ADGRG3 adhesion G protein-coupled receptor G3 1.101
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.099
CTSG cathepsin G 1.098
NOX1 NADPH oxidase 1 1.096
VCAM1 vascular cell adhesion molecule 1 1.095
IFNA1 interferon, alpha 1 1.095
RIPK3 receptor-interacting serine-threonine kinase 3 1.093
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.092
IRAK1 interleukin-1 receptor-associated kinase 1 1.091
IL17RA interleukin 17 receptor A 1.091
GSDME gasdermin E 1.09
GAS6 growth arrest-specific 6 1.089
NOS2 nitric oxide synthase 2, inducible 1.088
CP ceruloplasmin (ferroxidase) 1.087
AHR aryl hydrocarbon receptor 1.086
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.083
N4BP2 NEDD4 binding protein 2 1.08
ENO2 enolase 2 (gamma, neuronal) 1.079
ACRV1 acrosomal vesicle protein 1 1.079
MAP1S microtubule-associated protein 1S 1.078
TBX21 T-box 21 1.078
MMP13 matrix metallopeptidase 13 1.077
IL4R interleukin 4 receptor 1.076
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.074
IGF1 insulin-like growth factor 1 (somatomedin C) 1.074
C3 complement component 3 1.073
TFEB transcription factor EB 1.071
SOX3 SRY (sex determining region Y)-box 3 1.07
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.069
FGF18 fibroblast growth factor 18 1.066
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.066
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.065
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 1.065
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.064
CIITA class II, major histocompatibility complex, transactivator 1.063
CSF3 colony stimulating factor 3 (granulocyte) 1.063
FGF9 fibroblast growth factor 9 1.057
FGF17 fibroblast growth factor 17 1.057
CD69 CD69 molecule 1.055
LTA lymphotoxin alpha 1.052
CCL7 chemokine (C-C motif) ligand 7 1.05
FGF22 fibroblast growth factor 22 1.05
CD274 CD274 molecule 1.049
FGF6 fibroblast growth factor 6 1.048
FGF16 fibroblast growth factor 16 1.048
NLRC5 NLR family, CARD domain containing 5 1.048
FGF20 fibroblast growth factor 20 1.046
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.041
FGF5 fibroblast growth factor 5 1.04
CAMP cathelicidin antimicrobial peptide 1.04
CARD8 caspase recruitment domain family, member 8 1.039
ELMOD2 ELMO/CED-12 domain containing 2 1.037
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.037
FGF3 fibroblast growth factor 3 1.035
ARRDC1 arrestin domain containing 1 1.034
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 1.034
TSG101 tumor susceptibility 101 1.033
LAMP1 lysosomal-associated membrane protein 1 1.033
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.03
CD40 CD40 molecule, TNF receptor superfamily member 5 1.03
CD34 CD34 molecule 1.029
NCF4 neutrophil cytosolic factor 4, 40kDa 1.029
NLRP10 NLR family, pyrin domain containing 10 1.028
FGF4 fibroblast growth factor 4 1.025
FGF8 fibroblast growth factor 8 (androgen-induced) 1.025
TERT telomerase reverse transcriptase 1.024
IL7 interleukin 7 1.024
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.022
SELL selectin L 1.022
MAP1B microtubule-associated protein 1B 1.021
EDN1 endothelin 1 1.02
REN renin 1.019
SOD2 superoxide dismutase 2, mitochondrial 1.018
PRDX1 peroxiredoxin 1 1.017
TMEM11 transmembrane protein 11 1.016
WNT5A wingless-type MMTV integration site family, member 5A 1.013
OR4D9 olfactory receptor, family 4, subfamily D, member 9 1.012
ZNF609 zinc finger protein 609 1.01
SOCS3 suppressor of cytokine signaling 3 1.008
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.008
TGFA transforming growth factor, alpha 1.005
TICAM1 toll-like receptor adaptor molecule 1 1.004
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.003
SIGMAR1 sigma non-opioid intracellular receptor 1 1.003
SREK1 splicing regulatory glutamine/lysine-rich protein 1 1.002
KCNK6 potassium channel, two pore domain subfamily K, member 6 1.002
TSLP thymic stromal lymphopoietin 1.0