Silicosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. (Human Disease Ontology, DOID_10325)
External Link https://www.disgenet.org/browser/0/1/0/C0037116
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Genes

110 genes associated with the disease Silicosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 angiopoietin 1
APOA1 apolipoprotein A-I
ARG1 arginase 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BBC3 BCL2 binding component 3
BMP7 bone morphogenetic protein 7
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C4B_2 complement component 4B (Chido blood group), copy 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL7 chemokine (C-C motif) ligand 7
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CENPB centromere protein B, 80kDa
CHIA chitinase, acidic
COX2
CPM carboxypeptidase M
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
DSP desmoplakin
EGR1 early growth response 1
ELN elastin
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FN1 fibronectin 1
FSTL1 follistatin-like 1
GAS6 growth arrest-specific 6
GSTP1 glutathione S-transferase pi 1
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
IFNG interferon, gamma
IGLL5 immunoglobulin lambda-like polypeptide 5
IL10 interleukin 10
IL12B interleukin 12B
IL17A interleukin 17A
IL17F interleukin 17F
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
INTS4 integrator complex subunit 4
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
MARCO macrophage receptor with collagenous structure
MBL2 mannose-binding lectin (protein C) 2, soluble
MGMT O-6-methylguanine-DNA methyltransferase
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMRN1 multimerin 1
MSC musculin
MUC1 mucin 1, cell surface associated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NPNT nephronectin
PDZRN4 PDZ domain containing ring finger 4
PPARG peroxisome proliferator-activated receptor gamma
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRB1 proline-rich protein BstNI subfamily 1
PRKCB protein kinase C, beta
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REN renin
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SELL selectin L
SFTPD surfactant protein D
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
TEK TEK tyrosine kinase, endothelial
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TM7SF2 transmembrane 7 superfamily member 2
TNF tumor necrosis factor
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TP53 tumor protein p53
WNT3 wingless-type MMTV integration site family, member 3
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1