| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5312125 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Silodosin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF449 | zinc finger protein 449 | 3.1 |
| SERF2 | small EDRK-rich factor 2 | 1.05 |
| METAP2 | methionyl aminopeptidase 2 | 0.94 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.66 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | 0.65 |
| ERICH5 | glutamate-rich 5 | 0.63 |
| ZNF91 | zinc finger protein 91 | 0.63 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.55 |
| TIGD2 | tigger transposable element derived 2 | 0.54 |
| RPL31 | ribosomal protein L31 | 0.53 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.51 |
| R3HDM4 | R3H domain containing 4 | 0.51 |
| TNXB | tenascin XB | 0.49 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.46 |
| IL17RB | interleukin 17 receptor B | 0.45 |
| ZNF805 | zinc finger protein 805 | 0.44 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.43 |
| PRR5 | proline rich 5 (renal) | 0.39 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.39 |
| KIAA0586 | KIAA0586 | 0.38 |
| PSEN2 | presenilin 2 | 0.36 |
| UBQLN2 | ubiquilin 2 | 0.36 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 0.36 |
| ZNF503 | zinc finger protein 503 | 0.36 |
| H1-0 | H1.0 linker histone | 0.35 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.35 |
| CAPN6 | calpain 6 | 0.34 |
| DBF4 | DBF4 zinc finger | 0.34 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.34 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.34 |
| UBQLN1 | ubiquilin 1 | 0.33 |
| KIAA0753 | KIAA0753 | 0.33 |
| RPLP1 | ribosomal protein, large, P1 | 0.33 |
| KCTD18 | potassium channel tetramerization domain containing 18 | 0.33 |
| MYOM3 | myomesin 3 | 0.33 |
| PPP1R2B | PPP1R2 family member B | 0.33 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.33 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.32 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.32 |
| NFYA | nuclear transcription factor Y, alpha | 0.32 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.32 |
| EYS | eyes shut homolog (Drosophila) | 0.32 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.32 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.31 |
| DST | dystonin | 0.31 |
| WDR60 | WD repeat domain 60 | 0.31 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.31 |
| DOCK3 | dedicator of cytokinesis 3 | 0.3 |
| FOXP1 | forkhead box P1 | 0.3 |
| RPL23A | ribosomal protein L23a | 0.3 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.3 |
| PMF1 | polyamine-modulated factor 1 | 0.3 |
| L1RE1 | LINE1 retrotransposable element 1 | 0.3 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.3 |
| ZNF275 | zinc finger protein 275 | 0.3 |
| CCDC112 | coiled-coil domain containing 112 | 0.29 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.29 |
| TMEM179B | transmembrane protein 179B | 0.29 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.29 |
| NHP2 | NHP2 ribonucleoprotein | 0.28 |
| H1-3 | H1.3 linker histone, cluster member | 0.28 |
| ZNF280B | zinc finger protein 280B | 0.28 |
| YAP1 | Yes-associated protein 1 | 0.28 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.28 |
| IMMT | inner membrane protein, mitochondrial | 0.28 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.28 |
| HMCES | 5-hydroxymethylcytosine (hmC) binding, ES cell-specific | 0.28 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.28 |
| LIME1 | Lck interacting transmembrane adaptor 1 | 0.28 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.28 |
| TMEM101 | transmembrane protein 101 | 0.28 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.28 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.28 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.28 |
| EIF4E2 | eukaryotic translation initiation factor 4E family member 2 | 0.27 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.27 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | 0.27 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.27 |
| H3C1 | H3 clustered histone 1 | 0.26 |
| CTSV | cathepsin V | 0.26 |
| SON | SON DNA binding protein | 0.26 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | 0.26 |
| GRAMD2B | GRAM domain containing 2B | 0.26 |
| GGT1 | gamma-glutamyltransferase 1 | 0.26 |
| PEMT | phosphatidylethanolamine N-methyltransferase | 0.26 |
| ENO1 | enolase 1, (alpha) | 0.25 |
| MANEA | mannosidase, endo-alpha | 0.25 |
| TMEM189 | transmembrane protein 189 | 0.25 |
| DNM1 | dynamin 1 | 0.25 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.25 |
| DENND5A | DENN/MADD domain containing 5A | 0.25 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.25 |
| FANCF | Fanconi anemia, complementation group F | 0.25 |
| ZNF296 | zinc finger protein 296 | 0.25 |
| EPDR1 | ependymin related 1 | 0.25 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.25 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.24 |
| CEP89 | centrosomal protein 89kDa | 0.24 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.24 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | -2.04 |
| BCOR | BCL6 corepressor | -1.1 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.84 |
| PRDM16 | PR domain containing 16 | -0.75 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | -0.75 |
| ABHD18 | abhydrolase domain containing 18 | -0.71 |
| ACTBL2 | actin, beta-like 2 | -0.66 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.64 |
| HOXA7 | homeobox A7 | -0.62 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.55 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.52 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.5 |
| HIST1H1T | histone cluster 1, H1t | -0.5 |
| IPMK | inositol polyphosphate multikinase | -0.44 |
| NGFR | nerve growth factor receptor | -0.43 |
| XBP1 | X-box binding protein 1 | -0.42 |
| CFAP410 | cilia and flagella associated protein 410 | -0.42 |
| SRRD | SRR1 domain containing | -0.42 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | -0.41 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.38 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.38 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.37 |
| VWA1 | von Willebrand factor A domain containing 1 | -0.37 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.36 |
| PRR36 | proline rich 36 | -0.35 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.35 |
| FLNA | filamin A, alpha | -0.35 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.34 |
| FAM171B | family with sequence similarity 171, member B | -0.34 |
| ZNF746 | zinc finger protein 746 | -0.33 |
| CBX7 | chromobox homolog 7 | -0.33 |
| ABHD17C | abhydrolase domain containing 17C | -0.33 |
| C6ORF141 | chromosome 6 open reading frame 141 | -0.32 |
| RAB5IF | RAB5 interacting factor | -0.32 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.31 |
| STOML1 | stomatin (EPB72)-like 1 | -0.31 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | -0.31 |
| SNTA1 | syntrophin, alpha 1 | -0.3 |
| ZNF394 | zinc finger protein 394 | -0.3 |
| GSTZ1 | glutathione S-transferase zeta 1 | -0.3 |
| CDC25B | cell division cycle 25B | -0.3 |
| PUM1 | pumilio RNA-binding family member 1 | -0.3 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.3 |
| TTYH3 | tweety family member 3 | -0.3 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.29 |
| HBA1 | hemoglobin, alpha 1 | -0.29 |
| HFE | hemochromatosis | -0.28 |
| SEC61B | Sec61 beta subunit | -0.28 |
| MTF1 | metal-regulatory transcription factor 1 | -0.28 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.28 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | -0.27 |
| YIPF1 | Yip1 domain family, member 1 | -0.27 |
| LYST | lysosomal trafficking regulator | -0.27 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.27 |
| PACRGL | PARK2 co-regulated-like | -0.27 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | -0.26 |
| RNF169 | ring finger protein 169 | -0.26 |
| LRRC58 | leucine rich repeat containing 58 | -0.26 |
| SP4 | Sp4 transcription factor | -0.26 |
| NMU | neuromedin U | -0.25 |
| FSTL1 | follistatin-like 1 | -0.25 |
| MED22 | mediator complex subunit 22 | -0.25 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.25 |
| ZNF385B | zinc finger protein 385B | -0.25 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.25 |
| ATMIN | ATM interactor | -0.25 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.24 |
| MROH6 | maestro heat-like repeat family member 6 | -0.24 |
| RAB36 | RAB36, member RAS oncogene family | -0.24 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.24 |
| NAV2 | neuron navigator 2 | -0.23 |
| ZNF787 | zinc finger protein 787 | -0.23 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.23 |
| LIAS | lipoic acid synthetase | -0.23 |
| C2ORF72 | chromosome 2 open reading frame 72 | -0.23 |
| CCDC110 | coiled-coil domain containing 110 | -0.23 |
| SLC16A6 | solute carrier family 16, member 6 | -0.23 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | -0.23 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.23 |
| DEAF1 | DEAF1 transcription factor | -0.23 |
| XDH | xanthine dehydrogenase | -0.23 |
| CNST | consortin, connexin sorting protein | -0.23 |
| TMCO1 | transmembrane and coiled-coil domains 1 | -0.22 |
| SELENOW | selenoprotein W | -0.22 |
| E2F2 | E2F transcription factor 2 | -0.22 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.22 |
| MUC16 | mucin 16, cell surface associated | -0.22 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | -0.22 |
| RBM4B | RNA binding motif protein 4B | -0.22 |
| MPZL2 | myelin protein zero-like 2 | -0.22 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | -0.22 |
| GLRX5 | glutaredoxin 5 | -0.22 |
| DESI1 | desumoylating isopeptidase 1 | -0.22 |
| RGN | regucalcin | -0.22 |
| CCDC97 | coiled-coil domain containing 97 | -0.21 |
| CSNK1G1 | casein kinase 1, gamma 1 | -0.21 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.21 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.21 |
| HELQ | helicase, POLQ-like | -0.21 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.21 |
