| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Silodosin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Silodosin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.258737 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.232748 |
| FBN1 | fibrillin 1 | 0.137894 |
| COL1A2 | collagen, type I, alpha 2 | 0.0838018 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0836298 |
| PLAT | plasminogen activator, tissue | 0.0747333 |
| COL3A1 | collagen, type III, alpha 1 | 0.0642778 |
| ATP13A3 | ATPase type 13A3 | 0.0637582 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0610673 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0531788 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0511428 |
| SUCNR1 | succinate receptor 1 | 0.0505749 |
| CD44 | CD44 molecule (Indian blood group) | 0.0483168 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0469692 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0464573 |
| COL5A2 | collagen, type V, alpha 2 | 0.045724 |
| MEIS2 | Meis homeobox 2 | 0.0454408 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0427793 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0423245 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0398869 |
| XPO1 | exportin 1 | 0.0382055 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0381641 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0381377 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0364896 |
| GPC6 | glypican 6 | 0.0355098 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0353706 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0328943 |
| RNF145 | ring finger protein 145 | 0.03272 |
| RTN4 | reticulon 4 | 0.0316929 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0316732 |
| OPTN | optineurin | 0.0311106 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0304852 |
| EHBP1 | EH domain binding protein 1 | 0.029904 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0299021 |
| NPR2 | natriuretic peptide receptor 2 | 0.0298486 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0295324 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0294523 |
| USP3 | ubiquitin specific peptidase 3 | 0.0292765 |
| MEF2A | myocyte enhancer factor 2A | 0.029187 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0286909 |
| NCKAP1 | NCK-associated protein 1 | 0.0286065 |
| MAP4 | microtubule-associated protein 4 | 0.028604 |
| LAMB1 | laminin, beta 1 | 0.0285276 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0284062 |
| B2M | beta-2-microglobulin | 0.0284001 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0280919 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0280282 |
| GLIS3 | GLIS family zinc finger 3 | 0.0279064 |
| ZNF148 | zinc finger protein 148 | 0.027695 |
| ITM2B | integral membrane protein 2B | 0.0276901 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.027021 |
| NUP58 | nucleoporin 58 | 0.0270177 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0266506 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0263915 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0257401 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.025703 |
| RNF24 | ring finger protein 24 | 0.025647 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0253496 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0252983 |
| WDR26 | WD repeat domain 26 | 0.0246686 |
| SP3 | Sp3 transcription factor | 0.0243958 |
| TMEM41B | transmembrane protein 41B | 0.0241086 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0240215 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.023943 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0238316 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0234325 |
| TBC1D5 | TBC1 domain family, member 5 | 0.023324 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0228963 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.022832 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0227317 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0226769 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.022578 |
| OGA | O-GlcNAcase | 0.0224954 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0224594 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0224397 |
| KIFAP3 | kinesin-associated protein 3 | 0.0224217 |
| MICU3 | mitochondrial calcium uptake family, member 3 | 0.0224029 |
| ITGAV | integrin, alpha V | 0.0223988 |
| CD47 | CD47 molecule | 0.0221315 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0220739 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.0220323 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0219952 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.021723 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0215359 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0213184 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0212862 |
| NBAS | neuroblastoma amplified sequence | 0.0210781 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0210575 |
| SNX9 | sorting nexin 9 | 0.0210268 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0209817 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.0209272 |
| VMP1 | vacuole membrane protein 1 | 0.0209201 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0208696 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0208423 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0206495 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0206492 |
| TPR | translocated promoter region, nuclear basket protein | 0.0205187 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0204679 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0203298 |
| CLU | clusterin | 0.0203189 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.190004 |
| VIM | vimentin | -0.154846 |
| COL5A1 | collagen, type V, alpha 1 | -0.148204 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.128402 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.113648 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.112561 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.106932 |
| NDRG1 | N-myc downstream regulated 1 | -0.0953771 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0917114 |
| CSTB | cystatin B (stefin B) | -0.0898833 |
| AHNAK | AHNAK nucleoprotein | -0.0852864 |
| LMNA | lamin A/C | -0.0834887 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0790912 |
| LOX | lysyl oxidase | -0.0774181 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0732602 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0724065 |
| CDH13 | cadherin 13 | -0.0699077 |
| EGFR | epidermal growth factor receptor | -0.0680131 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0643236 |
| TMSB10 | thymosin beta 10 | -0.0642279 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0616134 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0602407 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.057948 |
| PRELID2 | PRELI domain containing 2 | -0.0575094 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0523161 |
| FN1 | fibronectin 1 | -0.0522774 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0521514 |
| HDAC9 | histone deacetylase 9 | -0.0485866 |
| RIGI | RNA sensor RIG-I | -0.0483878 |
| RND3 | Rho family GTPase 3 | -0.0470225 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0445993 |
| FSTL1 | follistatin-like 1 | -0.0436983 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0425741 |
| THBS2 | thrombospondin 2 | -0.0407325 |
| CENPF | centromere protein F, 350/400kDa | -0.0393519 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0384468 |
| ANXA2 | annexin A2 | -0.0383071 |
| EFNA5 | ephrin-A5 | -0.0380592 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0368769 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0364537 |
| VCL | vinculin | -0.0363115 |
| FTL | ferritin, light polypeptide | -0.0358709 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0358444 |
| MT2A | metallothionein 2A | -0.0356365 |
| FLNA | filamin A, alpha | -0.0354141 |
| RUNX1 | runt-related transcription factor 1 | -0.0346816 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0340552 |
| MYOF | myoferlin | -0.0338508 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0334493 |
| NAV2 | neuron navigator 2 | -0.033384 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0333765 |
| INTS6 | integrator complex subunit 6 | -0.0324038 |
| CANX | calnexin | -0.0321491 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0318383 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.031836 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0303084 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0302784 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0300427 |
| AEBP2 | AE binding protein 2 | -0.0297244 |
| RPLP2 | ribosomal protein, large, P2 | -0.0292659 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0291472 |
| PODXL | podocalyxin-like | -0.0287528 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0282313 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0279943 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0278748 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0277736 |
| HLA-B | major histocompatibility complex, class I, B | -0.0277722 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0277664 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0274454 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0273187 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0272298 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0268652 |
| RPL12 | ribosomal protein L12 | -0.0265275 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0264971 |
| SQSTM1 | sequestosome 1 | -0.0263439 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0262857 |
| MAP1B | microtubule-associated protein 1B | -0.0262107 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0262022 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0257976 |
| RPL23 | ribosomal protein L23 | -0.02579 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0256468 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0252325 |
| SEC61G | Sec61 gamma subunit | -0.0249007 |
| CALR | calreticulin | -0.0247065 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0246307 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0245469 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0243237 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.024174 |
| ANXA1 | annexin A1 | -0.0234213 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0230897 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0230435 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0226282 |
| RPL28 | ribosomal protein L28 | -0.0226254 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0225602 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.022432 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0220567 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0219595 |
| HLA-C | major histocompatibility complex, class I, C | -0.0219061 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0218977 |
| HM13 | histocompatibility (minor) 13 | -0.021882 |
