Silodosin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.106438
PCBP2 poly(rC) binding protein 2 0.0695208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.066286
MGAT4C MGAT4 family, member C 0.0499471
MED13L mediator complex subunit 13-like 0.0480003
BIRC6 baculoviral IAP repeat containing 6 0.0471756
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0469452
USP34 ubiquitin specific peptidase 34 0.0451827
PUM2 pumilio RNA-binding family member 2 0.0444763
VMP1 vacuole membrane protein 1 0.0411523
EPHA6 EPH receptor A6 0.0381898
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0370255
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.035815
CCNL1 cyclin L1 0.0357389
FXR1 fragile X mental retardation, autosomal homolog 1 0.0354809
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0340762
JMJD1C jumonji domain containing 1C 0.0318198
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0309304
TBC1D5 TBC1 domain family, member 5 0.0290496
YAP1 Yes-associated protein 1 0.0285548
NEK7 NIMA-related kinase 7 0.0285185
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0284985
CPOX coproporphyrinogen oxidase 0.0276139
CEP192 centrosomal protein 192kDa 0.0264559
CHD1 chromodomain helicase DNA binding protein 1 0.0249372
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0247865
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0244268
TBK1 TANK-binding kinase 1 0.0243324
CLDND1 claudin domain containing 1 0.0240759
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0238804
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0235173
PCM1 pericentriolar material 1 0.0229213
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0226214
AKAP9 A kinase (PRKA) anchor protein 9 0.0220729
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0219856
TMEM41B transmembrane protein 41B 0.0218272
ECT2 epithelial cell transforming 2 0.0216517
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0212773
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0211363
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0206873
CARD16 caspase recruitment domain family, member 16 0.0204138
EIF4B eukaryotic translation initiation factor 4B 0.0203751
CEP70 centrosomal protein 70kDa 0.0203707
PDGFC platelet derived growth factor C 0.0202028
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.020092
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0200918
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0200834
ERRFI1 ERBB receptor feedback inhibitor 1 0.020058
MED13 mediator complex subunit 13 0.0199658
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0196875
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.01968
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0193183
KMT2C lysine (K)-specific methyltransferase 2C 0.0192999
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0192773
PICALM phosphatidylinositol binding clathrin assembly protein 0.0191601
MMP12 matrix metallopeptidase 12 0.0191586
PRKCI protein kinase C, iota 0.0187608
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0185628
PEG10 paternally expressed 10 0.0184602
WNK1 WNK lysine deficient protein kinase 1 0.0182089
CCN2 cellular communication network factor 2 0.0182068
NCKAP1 NCK-associated protein 1 0.0182028
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0181989
MEMO1 mediator of cell motility 1 0.0181559
SFPQ splicing factor proline/glutamine-rich 0.018059
TXNRD1 thioredoxin reductase 1 0.0180145
FAM168A family with sequence similarity 168, member A 0.017841
SNX13 sorting nexin 13 0.0176155
NEGR1 neuronal growth regulator 1 0.0176022
MICU3 mitochondrial calcium uptake family, member 3 0.0174597
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0174374
XPO1 exportin 1 0.0173816
ATL2 atlastin GTPase 2 0.0173044
GPBP1 GC-rich promoter binding protein 1 0.0171507
ZFAND3 zinc finger, AN1-type domain 3 0.0171317
BLTP1 bridge-like lipid transfer protein family member 1 0.0170724
PSME4 proteasome (prosome, macropain) activator subunit 4 0.017038
UBA6 ubiquitin-like modifier activating enzyme 6 0.0168767
CAND1 cullin-associated and neddylation-dissociated 1 0.0168254
GASK1B golgi associated kinase 1B 0.0167243
FAT1 FAT atypical cadherin 1 0.0167166
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0166853
HSPA4 heat shock 70kDa protein 4 0.0166449
NF1 neurofibromin 1 0.0165873
BCAS3 breast carcinoma amplified sequence 3 0.016489
POU2F1 POU class 2 homeobox 1 0.016398
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0163571
FRYL FRY-like 0.0163075
TBC1D32 TBC1 domain family, member 32 0.0162583
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0162123
PHF21A PHD finger protein 21A 0.0159994
USP24 ubiquitin specific peptidase 24 0.0159608
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0159265
TNRC6A trinucleotide repeat containing 6A 0.0159026
SRPK2 SRSF protein kinase 2 0.0158601
MATR3 matrin 3 0.0157709
CAMKMT calmodulin-lysine N-methyltransferase 0.0157336
PNN pinin, desmosome associated protein 0.0157295
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0157199
OSBPL8 oxysterol binding protein-like 8 0.0156705

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.259105
TMSB10 thymosin beta 10 -0.194714
AREG amphiregulin -0.150659
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115954
FTL ferritin, light polypeptide -0.10098
RPL35A ribosomal protein L35a -0.072444
RPL23 ribosomal protein L23 -0.0609156
MYL12B myosin, light chain 12B, regulatory -0.0599714
RPS3 ribosomal protein S3 -0.0587159
RPS19 ribosomal protein S19 -0.0558056
CNRIP1 cannabinoid receptor interacting protein 1 -0.0557885
RPL37A ribosomal protein L37a -0.0553268
RPS8 ribosomal protein S8 -0.0552587
RPS12 ribosomal protein S12 -0.0540277
PTMA prothymosin, alpha -0.053027
RPLP2 ribosomal protein, large, P2 -0.0526545
RPL12 ribosomal protein L12 -0.0509026
YBX3 Y box binding protein 3 -0.0497228
ACTG1 actin gamma 1 -0.0490966
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0490772
RPS27A ribosomal protein S27a -0.0468221
RPS16 ribosomal protein S16 -0.0450972
TPT1 tumor protein, translationally-controlled 1 -0.044845
RPLP1 ribosomal protein, large, P1 -0.0438221
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0436175
RPL19 ribosomal protein L19 -0.043455
RPL36 ribosomal protein L36 -0.0409828
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0398674
IFIH1 interferon induced with helicase C domain 1 -0.0372143
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0351791
RPL37 ribosomal protein L37 -0.0341623
RPS6 ribosomal protein S6 -0.0335157
RPL8 ribosomal protein L8 -0.0334879
RPS14 ribosomal protein S14 -0.0333017
ZNF804A zinc finger protein 804A -0.0328467
RACK1 receptor for activated C kinase 1 -0.0317977
RPL34 ribosomal protein L34 -0.0311683
TPI1 triosephosphate isomerase 1 -0.0305732
PFN1 profilin 1 -0.0301895
H1-0 H1.0 linker histone -0.0301879
RPS13 ribosomal protein S13 -0.0301638
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0300577
DLC1 DLC1 Rho GTPase activating protein -0.0298883
HMGA2 high mobility group AT-hook 2 -0.0293073
RPL9 ribosomal protein L9 -0.0292659
RPL36A ribosomal protein L36a -0.0292143
EIF1 eukaryotic translation initiation factor 1 -0.0290017
NLGN1 neuroligin 1 -0.0289374
TM4SF1 transmembrane 4 L six family member 1 -0.0286664
PCDH7 protocadherin 7 -0.0279913
RPL26 ribosomal protein L26 -0.0277361
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0272228
RPLP0 ribosomal protein, large, P0 -0.0271976
ADGRG6 adhesion G protein-coupled receptor G6 -0.0269577
RPL31 ribosomal protein L31 -0.026522
TUBA1B tubulin, alpha 1b -0.0263386
AHNAK AHNAK nucleoprotein -0.02632
CALR calreticulin -0.026314
RPS29 ribosomal protein S29 -0.0261968
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0260457
SMC4 structural maintenance of chromosomes 4 -0.025551
CLDN1 claudin 1 -0.0251658
MAP1B microtubule-associated protein 1B -0.0246751
HMGB1 high mobility group box 1 -0.0245654
RPL18 ribosomal protein L18 -0.0244043
RPL11 ribosomal protein L11 -0.0242103
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0241878
RPS10 ribosomal protein S10 -0.0241513
ADIPOR2 adiponectin receptor 2 -0.0238881
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0231853
S100A6 S100 calcium binding protein A6 -0.0230739
CAVIN1 caveolae associated protein 1 -0.022987
RPS17 ribosomal protein S17 -0.0228714
RPL7 ribosomal protein L7 -0.0228664
RPS5 ribosomal protein S5 -0.022748
LMO7 LIM domain 7 -0.0220356
RPS24 ribosomal protein S24 -0.0218951
RPS27 ribosomal protein S27 -0.0218123
RSL1D1 ribosomal L1 domain containing 1 -0.021803
MTAP methylthioadenosine phosphorylase -0.0217371
RPL38 ribosomal protein L38 -0.0213315
RPL10A ribosomal protein L10a -0.0213167
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0210999
BCHE butyrylcholinesterase -0.0210233
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0209754
TBCA tubulin folding cofactor A -0.0205471
RPL13A ribosomal protein L13a -0.0204659
MYPN myopalladin -0.0203166
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.020259
RPL32 ribosomal protein L32 -0.0200454
NDUFA4 NDUFA4, mitochondrial complex associated -0.0198385
CELF2 CUGBP, Elav-like family member 2 -0.0197163
RPL5 ribosomal protein L5 -0.0196937
RPL27 ribosomal protein L27 -0.0196513
RPS23 ribosomal protein S23 -0.0196508
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0194549
RPL7A ribosomal protein L7a -0.0192165
CMIP c-Maf inducing protein -0.0191787
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0190887
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0190856