Silodosin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Silodosin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.154921
LSAMP limbic system-associated membrane protein 0.117301
RBMS3 RNA binding motif, single stranded interacting protein 3 0.063799
LPIN1 lipin 1 0.0558358
RNF213 ring finger protein 213 0.0557341
DST dystonin 0.052078
PTPRD protein tyrosine phosphatase, receptor type, D 0.0508656
CDH10 cadherin 10, type 2 (T2-cadherin) 0.049506
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0493564
TRIO trio Rho guanine nucleotide exchange factor 0.0489008
THSD4 thrombospondin, type I, domain containing 4 0.0478072
NALF1 NALCN channel auxiliary factor 1 0.0474201
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0470728
XPO1 exportin 1 0.0465371
CHD9 chromodomain helicase DNA binding protein 9 0.0446346
MSI2 musashi RNA-binding protein 2 0.0410193
PRKCA protein kinase C, alpha 0.0409457
LINGO2 leucine rich repeat and Ig domain containing 2 0.0391551
DNM3 dynamin 3 0.0387344
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0383732
ANTXR1 anthrax toxin receptor 1 0.0373318
AUTS2 autism susceptibility candidate 2 0.0371056
TAS2R14 taste receptor, type 2, member 14 0.0367045
UNC5C unc-5 homolog C (C. elegans) 0.0361655
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0354986
SOS1 son of sevenless homolog 1 (Drosophila) 0.0344095
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0343156
COL3A1 collagen, type III, alpha 1 0.0341988
RPTOR regulatory associated protein of MTOR, complex 1 0.0337877
SMYD3 SET and MYND domain containing 3 0.0336694
PUM2 pumilio RNA-binding family member 2 0.0334479
MX2 MX dynamin-like GTPase 2 0.0332346
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0331014
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0329482
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0321286
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0319716
CANX calnexin 0.0309528
VMP1 vacuole membrane protein 1 0.0307111
EXT1 exostosin glycosyltransferase 1 0.0304564
BBX bobby sox homolog (Drosophila) 0.0304074
ITGAV integrin, alpha V 0.0297879
BICD1 bicaudal D homolog 1 (Drosophila) 0.0297744
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0295126
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0294643
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0293725
NCAM2 neural cell adhesion molecule 2 0.0290388
CEMIP2 cell migration inducing hyaluronidase 2 0.0289246
NRP1 neuropilin 1 0.0284524
DGKH diacylglycerol kinase, eta 0.0284384
BPTF bromodomain PHD finger transcription factor 0.0283682
TBC1D5 TBC1 domain family, member 5 0.0282839
EFNA5 ephrin-A5 0.0282639
N4BP2L2 NEDD4 binding protein 2-like 2 0.0276269
KLHL13 kelch-like family member 13 0.0273524
RAD51B RAD51 paralog B 0.0268751
ZNF638 zinc finger protein 638 0.0265796
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0265526
PDE4D phosphodiesterase 4D, cAMP-specific 0.0264368
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0263648
DSCAM Down syndrome cell adhesion molecule 0.0263637
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0259256
PTEN phosphatase and tensin homolog 0.0258495
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0257814
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0257801
APP amyloid beta (A4) precursor protein 0.0256454
CSNK1A1 casein kinase 1, alpha 1 0.0255328
SH3PXD2A SH3 and PX domains 2A 0.0254273
RIGI RNA sensor RIG-I 0.0253002
NREP neuronal regeneration related protein 0.0252213
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0251865
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0251596
SIK3 SIK family kinase 3 0.0249569
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0245272
MAML2 mastermind-like 2 (Drosophila) 0.0244701
NAMPT nicotinamide phosphoribosyltransferase 0.0244676
PDZRN3 PDZ domain containing ring finger 3 0.0243141
RC3H1 ring finger and CCCH-type domains 1 0.0241721
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0240959
FTO fat mass and obesity associated 0.0239748
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0239329
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0234651
OSBPL1A oxysterol binding protein-like 1A 0.0234638
WDR43 WD repeat domain 43 0.023306
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0232426
SOX4 SRY (sex determining region Y)-box 4 0.0232287
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0229662
EIF4B eukaryotic translation initiation factor 4B 0.0229659
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0229485
CUX1 cut-like homeobox 1 0.0229267
TULP4 tubby like protein 4 0.0228255
CCDC14 coiled-coil domain containing 14 0.0227348
DENND4C DENN/MADD domain containing 4C 0.0226236
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0226084
ARHGAP9 Rho GTPase activating protein 9 0.0225813
DLC1 DLC1 Rho GTPase activating protein 0.0225551
KDM5A lysine (K)-specific demethylase 5A 0.0224153
PCBP2 poly(rC) binding protein 2 0.0223234
CLINT1 clathrin interactor 1 0.0222431
LARP4B La ribonucleoprotein domain family, member 4B 0.0222146
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0221811

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208733
IGF2 insulin-like growth factor 2 -0.164988
VIM vimentin -0.131331
PTMA prothymosin, alpha -0.109501
RPL23 ribosomal protein L23 -0.0903123
RPLP1 ribosomal protein, large, P1 -0.0751641
RPL34 ribosomal protein L34 -0.0748166
RPL35A ribosomal protein L35a -0.0713843
TPT1 tumor protein, translationally-controlled 1 -0.0614416
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0592979
EIF1 eukaryotic translation initiation factor 1 -0.0571463
RPL19 ribosomal protein L19 -0.0563566
RPS6 ribosomal protein S6 -0.0519668
TMSB10 thymosin beta 10 -0.0518073
RPS19 ribosomal protein S19 -0.0505495
RPS3 ribosomal protein S3 -0.0502674
RPL27 ribosomal protein L27 -0.0500155
RPS24 ribosomal protein S24 -0.0495693
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0474437
S100A6 S100 calcium binding protein A6 -0.0472693
AKAP12 A kinase (PRKA) anchor protein 12 -0.0472507
RPL31 ribosomal protein L31 -0.0467755
RPS8 ribosomal protein S8 -0.0462365
RPS17 ribosomal protein S17 -0.0451429
ACTG1 actin gamma 1 -0.0444729
FTL ferritin, light polypeptide -0.0433815
RPL35 ribosomal protein L35 -0.0428211
VCL vinculin -0.0424415
RPL32 ribosomal protein L32 -0.0412539
RPL7A ribosomal protein L7a -0.0404395
RPL36 ribosomal protein L36 -0.0398317
RPL12 ribosomal protein L12 -0.0389295
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0384006
RPL38 ribosomal protein L38 -0.0378194
RPS11 ribosomal protein S11 -0.0372717
FAM162A family with sequence similarity 162, member A -0.0369285
EEF2 eukaryotic translation elongation factor 2 -0.0366295
STC1 stanniocalcin 1 -0.0365231
HLA-A major histocompatibility complex, class I, A -0.0345569
RPS12 ribosomal protein S12 -0.033877
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0337273
IER3 immediate early response 3 -0.0334472
RPL9 ribosomal protein L9 -0.0332014
RPL11 ribosomal protein L11 -0.0329131
RPS27 ribosomal protein S27 -0.0320544
RPL18 ribosomal protein L18 -0.0318
HAND2 heart and neural crest derivatives expressed 2 -0.0312735
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0311597
ATF4 activating transcription factor 4 -0.029871
SQSTM1 sequestosome 1 -0.0296914
RPS27A ribosomal protein S27a -0.0295532
RPS13 ribosomal protein S13 -0.0294696
RACK1 receptor for activated C kinase 1 -0.0287423
RPLP0 ribosomal protein, large, P0 -0.0285578
RPLP2 ribosomal protein, large, P2 -0.0285137
GPC5 glypican 5 -0.027973
B2M beta-2-microglobulin -0.0278292
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027652
S100A9 S100 calcium binding protein A9 -0.0275611
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0274976
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0272287
RPL30 ribosomal protein L30 -0.0271598
RPS16 ribosomal protein S16 -0.0264213
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0263602
RPL7 ribosomal protein L7 -0.0261879
RPL37 ribosomal protein L37 -0.0261431
TPST1 tyrosylprotein sulfotransferase 1 -0.0256692
DDIT4 DNA-damage-inducible transcript 4 -0.0255681
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0251408
RPL28 ribosomal protein L28 -0.0250624
GARS1 glycyl-tRNA synthetase 1 -0.0250346
SLC38A2 solute carrier family 38, member 2 -0.0249352
ARF1 ADP-ribosylation factor 1 -0.0247797
FMN1 formin 1 -0.0247636
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0242568
PKM pyruvate kinase, muscle -0.0240981
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0237186
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0236777
RPL36A ribosomal protein L36a -0.0236719
RPS29 ribosomal protein S29 -0.0233875
NDRG1 N-myc downstream regulated 1 -0.0232419
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0225538
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0220121
SERF2 small EDRK-rich factor 2 -0.0217948
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0216517
RPL15 ribosomal protein L15 -0.0215288
RPS21 ribosomal protein S21 -0.0214899
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0214063
GDF15 growth differentiation factor 15 -0.0213307
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0213127
TKT transketolase -0.0210211
RPL10A ribosomal protein L10a -0.0210053
SEPTIN2 septin 2 -0.0209389
WDR45B WD repeat domain 45B -0.0205106
DCAF7 DDB1 and CUL4 associated factor 7 -0.0204723
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0203053
MEIS2 Meis homeobox 2 -0.0202825
RIC1 RAB6A GEF complex partner 1 -0.0199724
FTH1 ferritin, heavy polypeptide 1 -0.0199555
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0198533