Silodosin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARHGAP26 Rho GTPase activating protein 26 0.075734
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0439427
GMDS GDP-mannose 4,6-dehydratase 0.0439008
SORBS1 sorbin and SH3 domain containing 1 0.0432448
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.041973
PTBP3 polypyrimidine tract binding protein 3 0.0405084
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0380771
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0363025
DSCAM Down syndrome cell adhesion molecule 0.0358673
UBAC2 UBA domain containing 2 0.0332985
IFNGR1 interferon gamma receptor 1 0.0325635
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0321552
RUNX1 runt-related transcription factor 1 0.0305988
MSI2 musashi RNA-binding protein 2 0.0299375
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0292113
IGF1R insulin-like growth factor 1 receptor 0.0290325
NEBL nebulette 0.0285969
ETV6 ets variant 6 0.0284066
ZNF652 zinc finger protein 652 0.0280201
SSH2 slingshot protein phosphatase 2 0.0272836
RNF43 ring finger protein 43 0.0272616
PHIP pleckstrin homology domain interacting protein 0.0270851
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0263948
BCLAF1 BCL2-associated transcription factor 1 0.0258253
AFF1 AF4/FMR2 family, member 1 0.0254296
ASPH aspartate beta-hydroxylase 0.0253095
TMEM39A transmembrane protein 39A 0.0251255
KIF16B kinesin family member 16B 0.0250213
PTK2 protein tyrosine kinase 2 0.025003
HBS1L HBS1-like translational GTPase 0.024901
ATXN1 ataxin 1 0.0247338
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0243228
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0237428
PTPRJ protein tyrosine phosphatase, receptor type, J 0.02272
DUSP16 dual specificity phosphatase 16 0.0226629
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224073
GIGYF2 GRB10 interacting GYF protein 2 0.022254
TRIO trio Rho guanine nucleotide exchange factor 0.0221097
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0218816
PDZD8 PDZ domain containing 8 0.0218305
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0216897
SETX senataxin 0.0212799
MACF1 microtubule-actin crosslinking factor 1 0.0211051
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.021038
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0206433
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0205989
VCL vinculin 0.0204583
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.020301
SPRED1 sprouty-related, EVH1 domain containing 1 0.0202629
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0199141
TNIK TRAF2 and NCK interacting kinase 0.0197886
YEATS2 YEATS domain containing 2 0.0195847
LPP LIM domain containing preferred translocation partner in lipoma 0.0194292
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.019191
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0191763
TXNRD1 thioredoxin reductase 1 0.0191029
TM9SF2 transmembrane 9 superfamily member 2 0.019013
UBA6 ubiquitin-like modifier activating enzyme 6 0.0187675
ERRFI1 ERBB receptor feedback inhibitor 1 0.0186709
LMTK2 lemur tyrosine kinase 2 0.0185947
MED13 mediator complex subunit 13 0.0184984
FNDC3A fibronectin type III domain containing 3A 0.0184307
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0182188
STEAP2 STEAP family member 2, metalloreductase 0.0181657
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0180085
TMEM161B transmembrane protein 161B 0.0179773
UBL3 ubiquitin-like 3 0.0178389
LY75-CD302 LY75-CD302 readthrough 0.0177594
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0177216
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0176236
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0174801
PTEN phosphatase and tensin homolog 0.0173488
BIRC6 baculoviral IAP repeat containing 6 0.0173245
DST dystonin 0.0173109
TC2N tandem C2 domains, nuclear 0.0172444
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.0172235
RABGAP1L RAB GTPase activating protein 1-like 0.017175
SMYD3 SET and MYND domain containing 3 0.0170899
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0170089
ARL15 ADP-ribosylation factor-like 15 0.0169957
BIRC3 baculoviral IAP repeat containing 3 0.0169813
FAT1 FAT atypical cadherin 1 0.0169309
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0168797
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.016735
ADAM10 ADAM metallopeptidase domain 10 0.0167172
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0164217
NBAS neuroblastoma amplified sequence 0.0163229
FNIP1 folliculin interacting protein 1 0.0163066
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0161889
IQGAP1 IQ motif containing GTPase activating protein 1 0.0161847
GLS2 glutaminase 2 (liver, mitochondrial) 0.0161581
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0160215
MINK1 misshapen-like kinase 1 0.016012
ALG11 ALG11, alpha-1,2-mannosyltransferase 0.0160048
R3HDM2 R3H domain containing 2 0.0159832
MTMR3 myotubularin related protein 3 0.0159673
DIAPH1 diaphanous-related formin 1 0.0159627
TCERG1 transcription elongation regulator 1 0.0159261
IL20RA interleukin 20 receptor, alpha 0.0159137
RAB22A RAB22A, member RAS oncogene family 0.0158159

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.196207
B2M beta-2-microglobulin -0.168935
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11621
HLA-B major histocompatibility complex, class I, B -0.111848
NDRG1 N-myc downstream regulated 1 -0.0863464
PTMA prothymosin, alpha -0.0811479
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0771564
H1-0 H1.0 linker histone -0.0744754
MT2A metallothionein 2A -0.0738342
TMSB10 thymosin beta 10 -0.0724944
RPL35A ribosomal protein L35a -0.0712248
FTL ferritin, light polypeptide -0.0689882
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0618752
PKM pyruvate kinase, muscle -0.0594348
IFI6 interferon, alpha-inducible protein 6 -0.0592982
RPL23 ribosomal protein L23 -0.0539832
RPS8 ribosomal protein S8 -0.0539789
SLC38A1 solute carrier family 38, member 1 -0.0526501
RPS3 ribosomal protein S3 -0.049007
RPL37 ribosomal protein L37 -0.0484663
EIF1 eukaryotic translation initiation factor 1 -0.0481978
RPLP1 ribosomal protein, large, P1 -0.0470847
RPL19 ribosomal protein L19 -0.0469123
RPS27 ribosomal protein S27 -0.0458302
LYZ lysozyme -0.0458
LCN2 lipocalin 2 -0.0448522
RPL26 ribosomal protein L26 -0.0445783
RPL34 ribosomal protein L34 -0.0444994
RPS6 ribosomal protein S6 -0.0436976
EGR1 early growth response 1 -0.0434986
HLA-A major histocompatibility complex, class I, A -0.0434551
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0434358
ANXA2 annexin A2 -0.0421842
CSTB cystatin B (stefin B) -0.0418587
RPS12 ribosomal protein S12 -0.0415025
TPI1 triosephosphate isomerase 1 -0.0414416
C6ORF132 chromosome 6 open reading frame 132 -0.0408581
RPS24 ribosomal protein S24 -0.0405045
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0403661
IFI27 interferon, alpha-inducible protein 27 -0.0391899
RPL7A ribosomal protein L7a -0.0380453
IFITM3 interferon induced transmembrane protein 3 -0.037958
KRT19 keratin 19, type I -0.0362389
RPL12 ribosomal protein L12 -0.03566
SP100 SP100 nuclear antigen -0.0345017
PRRC2C proline-rich coiled-coil 2C -0.0340896
GOLGA4 golgin A4 -0.0335405
XAF1 XIAP associated factor 1 -0.0334958
RPS19 ribosomal protein S19 -0.0330002
CALR calreticulin -0.0329717
GNAS GNAS complex locus -0.0325996
HLA-C major histocompatibility complex, class I, C -0.031974
AHNAK AHNAK nucleoprotein -0.0315577
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0315258
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.030788
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0305391
MUC20 mucin 20, cell surface associated -0.0303986
PGK1 phosphoglycerate kinase 1 -0.0303878
KLF6 Kruppel-like factor 6 -0.0297554
RACK1 receptor for activated C kinase 1 -0.0294356
RNF149 ring finger protein 149 -0.0294135
AREG amphiregulin -0.029408
RPL37A ribosomal protein L37a -0.0293142
S100A6 S100 calcium binding protein A6 -0.0293104
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0291734
WSB1 WD repeat and SOCS box containing 1 -0.0290975
MT1X metallothionein 1X -0.0290165
FN1 fibronectin 1 -0.0288762
FAM162A family with sequence similarity 162, member A -0.0286798
RPS27A ribosomal protein S27a -0.0285716
NIPBL Nipped-B homolog (Drosophila) -0.028312
RPL18 ribosomal protein L18 -0.0282513
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0282137
HLA-E major histocompatibility complex, class I, E -0.0280722
UBC ubiquitin C -0.028015
S100A10 S100 calcium binding protein A10 -0.0278821
PERP PERP, TP53 apoptosis effector -0.0278001
LOC102724023 ES1 protein homolog, mitochondrial -0.0272405
IGFBP3 insulin-like growth factor binding protein 3 -0.027186
SPATA13 spermatogenesis associated 13 -0.0271246
NACA nascent polypeptide-associated complex alpha subunit -0.0270318
RAB7A RAB7A, member RAS oncogene family -0.0270164
RPS29 ribosomal protein S29 -0.026935
MKI67 marker of proliferation Ki-67 -0.0269155
RPS13 ribosomal protein S13 -0.0264071
RPL31 ribosomal protein L31 -0.0263942
TMPRSS4 transmembrane protease, serine 4 -0.0263929
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0263914
MTDH metadherin -0.0262471
S100A9 S100 calcium binding protein A9 -0.0260958
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0260572
RPS16 ribosomal protein S16 -0.0260497
ISG15 ISG15 ubiquitin-like modifier -0.0258626
TMEM165 transmembrane protein 165 -0.0258343
WDR45B WD repeat domain 45B -0.0256783
RPL27 ribosomal protein L27 -0.0256757
TFF3 trefoil factor 3 (intestinal) -0.0256662
IER3 immediate early response 3 -0.0255354
GCC2 GRIP and coiled-coil domain containing 2 -0.0255012
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0254731