Silodosin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Silodosin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.107423
IGFBP3 insulin-like growth factor binding protein 3 0.099278
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0680405
ASPH aspartate beta-hydroxylase 0.065989
ZBTB20 zinc finger and BTB domain containing 20 0.0651813
PSD3 pleckstrin and Sec7 domain containing 3 0.0628119
DST dystonin 0.0591141
CXCL8 chemokine (C-X-C motif) ligand 8 0.0575334
EXT1 exostosin glycosyltransferase 1 0.0559203
HMGA2 high mobility group AT-hook 2 0.053216
VCAN versican 0.0526409
DPYD dihydropyrimidine dehydrogenase 0.0464537
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0462315
ALCAM activated leukocyte cell adhesion molecule 0.0417756
FBN1 fibrillin 1 0.0388777
INHBA inhibin, beta A 0.0387894
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0384971
FNDC3B fibronectin type III domain containing 3B 0.0382136
CD44 CD44 molecule (Indian blood group) 0.0373723
GLIS3 GLIS family zinc finger 3 0.0373617
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0368073
FN1 fibronectin 1 0.0342805
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0332174
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0316309
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0308631
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0308589
VMP1 vacuole membrane protein 1 0.0306656
MAML2 mastermind-like 2 (Drosophila) 0.0301142
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0298741
JAK2 Janus kinase 2 0.0294508
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0294084
OSMR oncostatin M receptor 0.0291324
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0291117
VEGFA vascular endothelial growth factor A 0.0289849
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0289083
HAS2 hyaluronan synthase 2 0.0284122
LTBP1 latent transforming growth factor beta binding protein 1 0.0282189
SMAD3 SMAD family member 3 0.0281994
MTSS1 metastasis suppressor 1 0.0279602
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.02777
WWTR1 WW domain containing transcription regulator 1 0.0276714
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0274896
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272875
ZFPM2 zinc finger protein, FOG family member 2 0.0270914
ANTXR2 anthrax toxin receptor 2 0.0269791
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0269137
MYH9 myosin, heavy chain 9, non-muscle 0.0269052
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0267145
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0266797
MACF1 microtubule-actin crosslinking factor 1 0.0259879
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0258517
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0258488
CNTN5 contactin 5 0.0252212
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0248225
ADAM12 ADAM metallopeptidase domain 12 0.0244624
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0242439
DPYSL3 dihydropyrimidinase-like 3 0.024155
GPC6 glypican 6 0.0241286
BNC2 basonuclin 2 0.0234712
FAT1 FAT atypical cadherin 1 0.0234162
RUNX2 runt-related transcription factor 2 0.0221189
MAP1B microtubule-associated protein 1B 0.0220068
ZBTB38 zinc finger and BTB domain containing 38 0.0214976
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0209839
EHBP1 EH domain binding protein 1 0.0208149
ASCC3 activating signal cointegrator 1 complex subunit 3 0.020788
LRP1B low density lipoprotein receptor-related protein 1B 0.0202504
NAV1 neuron navigator 1 0.0200073
TRPS1 trichorhinophalangeal syndrome I 0.0199963
FER fer (fps/fes related) tyrosine kinase 0.0198562
CENPF centromere protein F, 350/400kDa 0.0197759
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0196515
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0192952
CLIC4 chloride intracellular channel 4 0.018375
PICALM phosphatidylinositol binding clathrin assembly protein 0.0183736
ZEB2 zinc finger E-box binding homeobox 2 0.0182629
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.018053
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0179592
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0177757
PDE4D phosphodiesterase 4D, cAMP-specific 0.0176897
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0175456
SVIL supervillin 0.0174945
SMC4 structural maintenance of chromosomes 4 0.0172799
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0172662
VEGFC vascular endothelial growth factor C 0.0172559
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0169475
ARHGAP29 Rho GTPase activating protein 29 0.0168151
ATP13A3 ATPase type 13A3 0.0166515
SFPQ splicing factor proline/glutamine-rich 0.0166093
AXL AXL receptor tyrosine kinase 0.016563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0164585
POSTN periostin, osteoblast specific factor 0.0161777
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0160884
WNT5A wingless-type MMTV integration site family, member 5A 0.0157689
MSRB3 methionine sulfoxide reductase B3 0.0155702
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0155584
SOCS5 suppressor of cytokine signaling 5 0.015549
STAU2 staufen double-stranded RNA binding protein 2 0.0154787
MYO10 myosin X 0.0154783
PRR16 proline rich 16 0.0154693

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.290733
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.240323
VIM vimentin -0.218802
MT2A metallothionein 2A -0.187961
TMSB10 thymosin beta 10 -0.116077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114265
FTL ferritin, light polypeptide -0.0940235
COL1A1 collagen, type I, alpha 1 -0.0787592
CADM1 cell adhesion molecule 1 -0.0768386
RPS8 ribosomal protein S8 -0.0746101
RPL35A ribosomal protein L35a -0.0718604
PTMA prothymosin, alpha -0.0711754
IER3 immediate early response 3 -0.0633197
RPS6 ribosomal protein S6 -0.0584532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0563698
TPT1 tumor protein, translationally-controlled 1 -0.0495297
RPS19 ribosomal protein S19 -0.0482602
CALR calreticulin -0.0475326
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0470289
RPL23 ribosomal protein L23 -0.045378
EEF2 eukaryotic translation elongation factor 2 -0.0438011
RPS3 ribosomal protein S3 -0.0436136
RAB2A RAB2A, member RAS oncogene family -0.0430758
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0422495
RPS12 ribosomal protein S12 -0.04106
TGFBI transforming growth factor, beta-induced, 68kDa -0.0409992
RPL19 ribosomal protein L19 -0.0405487
RPL12 ribosomal protein L12 -0.0403179
RPL5 ribosomal protein L5 -0.0398979
HLA-B major histocompatibility complex, class I, B -0.0368412
RPL26 ribosomal protein L26 -0.036812
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0365644
RPS16 ribosomal protein S16 -0.0363217
GOLGA4 golgin A4 -0.0362259
MT1X metallothionein 1X -0.036098
RPL37A ribosomal protein L37a -0.0357256
WSB1 WD repeat and SOCS box containing 1 -0.0353586
RPL8 ribosomal protein L8 -0.0352538
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0351397
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0342492
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0338162
RPL11 ribosomal protein L11 -0.0336298
MTDH metadherin -0.0330769
CAMTA1 calmodulin binding transcription activator 1 -0.0327731
S100A9 S100 calcium binding protein A9 -0.032534
RPLP2 ribosomal protein, large, P2 -0.0324631
RPLP1 ribosomal protein, large, P1 -0.0319942
RPL36 ribosomal protein L36 -0.0316904
RACK1 receptor for activated C kinase 1 -0.0314809
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0314265
TRIO trio Rho guanine nucleotide exchange factor -0.0308951
DPYSL2 dihydropyrimidinase-like 2 -0.0303714
RPL28 ribosomal protein L28 -0.030152
ADM adrenomedullin -0.0300653
RPL30 ribosomal protein L30 -0.0298627
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0297475
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0296564
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0293433
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0289626
RAP1B RAP1B, member of RAS oncogene family -0.0287742
ACTG1 actin gamma 1 -0.0287086
RPL32 ribosomal protein L32 -0.0284696
EIF1 eukaryotic translation initiation factor 1 -0.0283509
RPL34 ribosomal protein L34 -0.0280872
RAB1A RAB1A, member RAS oncogene family -0.0279199
RBM39 RNA binding motif protein 39 -0.0271837
RPS24 ribosomal protein S24 -0.0269192
RAB7A RAB7A, member RAS oncogene family -0.0267126
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0264927
WASF2 WAS protein family, member 2 -0.0264055
RPL9 ribosomal protein L9 -0.0261997
HILPDA hypoxia inducible lipid droplet-associated -0.0261146
RPS20 ribosomal protein S20 -0.0261034
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260291
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0259661
RPS17 ribosomal protein S17 -0.0259619
ANKRD11 ankyrin repeat domain 11 -0.0258967
GARS1 glycyl-tRNA synthetase 1 -0.0256699
CAVIN1 caveolae associated protein 1 -0.0252966
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0252636
RPL7 ribosomal protein L7 -0.0251949
IFITM3 interferon induced transmembrane protein 3 -0.0251495
RPL31 ribosomal protein L31 -0.0247813
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0246485
TSC22D2 TSC22 domain family, member 2 -0.0244343
RPS5 ribosomal protein S5 -0.0244152
ZFAND3 zinc finger, AN1-type domain 3 -0.0243782
RPS13 ribosomal protein S13 -0.024247
RPL37 ribosomal protein L37 -0.0240034
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0239486
RPS25 ribosomal protein S25 -0.0239178
LOXL2 lysyl oxidase-like 2 -0.0236768
PFN1 profilin 1 -0.0234643
RLF rearranged L-myc fusion -0.0233365
MYO9B myosin IXB -0.0232743
SEC61G Sec61 gamma subunit -0.0230576
RPS27A ribosomal protein S27a -0.0229849
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0228886
RPS11 ribosomal protein S11 -0.0227904
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0226873