Silodosin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0355494
SULF1 sulfatase 1 0.0350578
DOCK5 dedicator of cytokinesis 5 0.0344184
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0341832
PRELID2 PRELI domain containing 2 0.0315852
RIN2 Ras and Rab interactor 2 0.0285279
CEMIP cell migration inducing protein, hyaluronan binding 0.0278144
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0272391
NRG1 neuregulin 1 0.0263352
NRIP1 nuclear receptor interacting protein 1 0.0248579
MBNL1 muscleblind-like splicing regulator 1 0.0233768
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0232417
MACF1 microtubule-actin crosslinking factor 1 0.023185
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.022206
NEK7 NIMA-related kinase 7 0.0219297
EFNA5 ephrin-A5 0.0211966
CAPRIN2 caprin family member 2 0.0201671
MTSS1 metastasis suppressor 1 0.0184373
MSN moesin 0.0183156
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0182694
SMAD3 SMAD family member 3 0.0179811
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0177397
DPYD dihydropyrimidine dehydrogenase 0.0174702
ZEB1 zinc finger E-box binding homeobox 1 0.0170092
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0164697
ADAM10 ADAM metallopeptidase domain 10 0.0163749
DOCK9 dedicator of cytokinesis 9 0.0161995
TBC1D5 TBC1 domain family, member 5 0.0155266
BLCAP bladder cancer associated protein 0.0154544
MYO10 myosin X 0.0151229
ASPH aspartate beta-hydroxylase 0.0146978
AOPEP aminopeptidase O (putative) 0.0146595
BCL2L1 BCL2-like 1 0.0146106
SBF2 SET binding factor 2 0.0143726
AMOTL1 angiomotin like 1 0.0142088
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0141463
LNPEP leucyl/cystinyl aminopeptidase 0.0139921
FN1 fibronectin 1 0.0138351
SLTM SAFB-like, transcription modulator 0.0137953
PRKCH protein kinase C, eta 0.0135888
EXOC4 exocyst complex component 4 0.0134346
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.01323
CUL4B cullin 4B 0.0131728
RAI14 retinoic acid induced 14 0.0131273
FNIP1 folliculin interacting protein 1 0.0131203
SMYD3 SET and MYND domain containing 3 0.0130688
IVNS1ABP influenza virus NS1A binding protein 0.0130276
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0129696
DOCK4 dedicator of cytokinesis 4 0.0129488
ATXN1 ataxin 1 0.0129461
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.012935
MAML2 mastermind-like 2 (Drosophila) 0.0127982
DOK5 docking protein 5 0.0126872
USP9X ubiquitin specific peptidase 9, X-linked 0.0126749
THSD4 thrombospondin, type I, domain containing 4 0.0126372
KIAA1217 KIAA1217 0.0124901
YEATS2 YEATS domain containing 2 0.012473
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0122915
LRRC8C leucine rich repeat containing 8 family, member C 0.0122546
COG6 component of oligomeric golgi complex 6 0.0122263
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0121967
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0116192
JAG1 jagged 1 0.0116023
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0115751
MYH9 myosin, heavy chain 9, non-muscle 0.0115485
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0114652
ZFC3H1 zinc finger, C3H1-type containing 0.0112586
EML6 echinoderm microtubule associated protein like 6 0.0112476
ARHGAP29 Rho GTPase activating protein 29 0.0112426
WDR26 WD repeat domain 26 0.011212
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0111081
ADGRL2 adhesion G protein-coupled receptor L2 0.0110946
AFAP1 actin filament associated protein 1 0.011039
FAR1 fatty acyl CoA reductase 1 0.0108759
CARD16 caspase recruitment domain family, member 16 0.0108401
EXOC6B exocyst complex component 6B 0.0108141
SFPQ splicing factor proline/glutamine-rich 0.0107718
FOXO1 forkhead box O1 0.0107418
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0104567
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0102901
EHBP1 EH domain binding protein 1 0.0102436
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0101419
EHF ets homologous factor 0.0101322
CD47 CD47 molecule 0.0101317
BMAL2 basic helix-loop-helix ARNT like 2 0.0101086
FOXP1 forkhead box P1 0.0101008
SDCCAG8 serologically defined colon cancer antigen 8 0.0100939
OSBPL3 oxysterol binding protein-like 3 0.0100337
TMF1 TATA element modulatory factor 1 0.00998708
RAD51B RAD51 paralog B 0.00998154
SSBP2 single-stranded DNA binding protein 2 0.00994068
ASCC3 activating signal cointegrator 1 complex subunit 3 0.00992811
ARID1A AT rich interactive domain 1A (SWI-like) 0.00985772
NBAS neuroblastoma amplified sequence 0.00971502
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00956936
CD46 CD46 molecule, complement regulatory protein 0.00938539
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00935098
N4BP2L2 NEDD4 binding protein 2-like 2 0.00929439
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.00927926
FRMD4A FERM domain containing 4A 0.00915347

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.183702
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181709
NDRG1 N-myc downstream regulated 1 -0.150629
B2M beta-2-microglobulin -0.115169
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.106868
MT2A metallothionein 2A -0.105863
TMSB10 thymosin beta 10 -0.0981679
PTMA prothymosin, alpha -0.0945
TPT1 tumor protein, translationally-controlled 1 -0.0919016
RPS6 ribosomal protein S6 -0.0787404
S100A10 S100 calcium binding protein A10 -0.07527
RPS8 ribosomal protein S8 -0.0750716
RPLP2 ribosomal protein, large, P2 -0.073349
RPS21 ribosomal protein S21 -0.0723777
IFITM3 interferon induced transmembrane protein 3 -0.0635679
RPS13 ribosomal protein S13 -0.0599352
GNAS GNAS complex locus -0.0595077
RPLP1 ribosomal protein, large, P1 -0.0577545
RPS19 ribosomal protein S19 -0.05773
LMNA lamin A/C -0.0574571
STC1 stanniocalcin 1 -0.0573644
RPL11 ribosomal protein L11 -0.057339
HLA-B major histocompatibility complex, class I, B -0.0549477
TMSB4X thymosin beta 4, X-linked -0.0524958
RPS3 ribosomal protein S3 -0.0512206
FTL ferritin, light polypeptide -0.05077
IGF2 insulin-like growth factor 2 -0.050525
ANXA1 annexin A1 -0.0502235
ENO1 enolase 1, (alpha) -0.0499849
LDHA lactate dehydrogenase A -0.0492785
RPS25 ribosomal protein S25 -0.048465
RPL37 ribosomal protein L37 -0.0482229
RPL8 ribosomal protein L8 -0.0475642
RPL35A ribosomal protein L35a -0.0472505
RPL12 ribosomal protein L12 -0.0468663
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0462478
S100A9 S100 calcium binding protein A9 -0.0462258
PGK1 phosphoglycerate kinase 1 -0.0454999
IFITM1 interferon induced transmembrane protein 1 -0.0451143
CLU clusterin -0.0447025
RPS12 ribosomal protein S12 -0.0425381
RPL34 ribosomal protein L34 -0.0420924
RPL23 ribosomal protein L23 -0.0420921
S100A11 S100 calcium binding protein A11 -0.042038
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.041925
KRT17 keratin 17, type I -0.0416967
S100A6 S100 calcium binding protein A6 -0.0407129
RPL19 ribosomal protein L19 -0.0405797
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0405255
RPL37A ribosomal protein L37a -0.0402945
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0393217
ANXA2 annexin A2 -0.0393156
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0389393
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0386338
S100A2 S100 calcium binding protein A2 -0.0385211
ALCAM activated leukocyte cell adhesion molecule -0.0383256
EIF1 eukaryotic translation initiation factor 1 -0.0374959
WASF2 WAS protein family, member 2 -0.0374873
SQSTM1 sequestosome 1 -0.0367759
CD44 CD44 molecule (Indian blood group) -0.035921
SQLE squalene epoxidase -0.0356211
RPL36 ribosomal protein L36 -0.0349121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348336
MT1X metallothionein 1X -0.0347919
RPS27A ribosomal protein S27a -0.0346151
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0342659
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0340176
POTEF POTE ankyrin domain family, member F -0.034001
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0338602
H1-0 H1.0 linker histone -0.0336807
RPL5 ribosomal protein L5 -0.0333719
RPL27A ribosomal protein L27a -0.0333689
RPS24 ribosomal protein S24 -0.0332837
LOC112694756 uncharaterized LOC112694756 -0.0328991
PKM pyruvate kinase, muscle -0.0324785
RPL31 ribosomal protein L31 -0.0322028
RPL7A ribosomal protein L7a -0.0321553
RPS27 ribosomal protein S27 -0.0320776
IFI6 interferon, alpha-inducible protein 6 -0.0315002
RPS16 ribosomal protein S16 -0.03142
CSTB cystatin B (stefin B) -0.0314086
RPS14 ribosomal protein S14 -0.0309963
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0309947
RPS29 ribosomal protein S29 -0.0308158
FTH1 ferritin, heavy polypeptide 1 -0.0307731
NAP1L1 nucleosome assembly protein 1-like 1 -0.0304455
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0302178
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0297747
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0295713
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0293064
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0292887
RPS23 ribosomal protein S23 -0.0292799
CAV1 caveolin 1, caveolae protein, 22kDa -0.0291884
PFN1 profilin 1 -0.029105
IFI27 interferon, alpha-inducible protein 27 -0.0290023
RPL28 ribosomal protein L28 -0.0287871
RPL32 ribosomal protein L32 -0.0287763
RPS11 ribosomal protein S11 -0.0287206
RACK1 receptor for activated C kinase 1 -0.0282539
HLA-A major histocompatibility complex, class I, A -0.0281579