Silodosin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0290834
EREG epiregulin 0.0191961
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0167307
FTH1 ferritin, heavy polypeptide 1 0.0164719
CD46 CD46 molecule, complement regulatory protein 0.0159192
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0155903
RNF145 ring finger protein 145 0.0152674
UBA6 ubiquitin-like modifier activating enzyme 6 0.0140746
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0136075
RNF43 ring finger protein 43 0.0134594
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0130819
MON2 MON2 homolog (S. cerevisiae) 0.0126907
COPA coatomer protein complex, subunit alpha 0.0121095
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0118085
ESRP1 epithelial splicing regulatory protein 1 0.0116293
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0113232
MBNL2 muscleblind-like splicing regulator 2 0.0113072
ZNF292 zinc finger protein 292 0.0112283
NCKAP1 NCK-associated protein 1 0.0111464
KDM6A lysine (K)-specific demethylase 6A 0.0110245
EIF4B eukaryotic translation initiation factor 4B 0.0107505
DERA deoxyribose-phosphate aldolase (putative) 0.0106898
PICALM phosphatidylinositol binding clathrin assembly protein 0.0104995
NUP58 nucleoporin 58 0.0101411
CDC73 cell division cycle 73 0.0100712
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00970406
SEC31A SEC31 homolog A (S. cerevisiae) 0.00969153
YTHDC1 YTH domain containing 1 0.0096822
SEC24D SEC24 family member D 0.00968212
TMEM39A transmembrane protein 39A 0.00934176
PTEN phosphatase and tensin homolog 0.009282
MAT2A methionine adenosyltransferase II, alpha 0.00921854
AFDN afadin, adherens junction formation factor 0.00917864
CUL3 cullin 3 0.00917355
RCOR3 REST corepressor 3 0.00902623
SCAF8 SR-related CTD-associated factor 8 0.00866503
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00856798
TCEA1 transcription elongation factor A (SII), 1 0.00842542
SNX13 sorting nexin 13 0.00839071
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00833487
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00831448
BTBD9 BTB (POZ) domain containing 9 0.00818052
SUCO SUN domain containing ossification factor 0.0081562
RFX7 regulatory factor X, 7 0.00812312
JAG1 jagged 1 0.00805585
GRB10 growth factor receptor-bound protein 10 0.00786557
CEMIP2 cell migration inducing hyaluronidase 2 0.00782728
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00780725
TOM1L1 target of myb1 (chicken)-like 1 0.00774391
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0076938
UBQLN1 ubiquilin 1 0.00751833
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00750867
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.00746958
PTBP2 polypyrimidine tract binding protein 2 0.00745114
TFRC transferrin receptor 0.0074044
SPRED1 sprouty-related, EVH1 domain containing 1 0.00738835
PCDHB16 protocadherin beta 16 0.00737578
NAMPT nicotinamide phosphoribosyltransferase 0.00728088
COG5 component of oligomeric golgi complex 5 0.00724956
ZC3H11A zinc finger CCCH-type containing 11A 0.00719563
NFXL1 nuclear transcription factor, X-box binding-like 1 0.00718138
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.00713968
TXNRD1 thioredoxin reductase 1 0.00711137
RSRC2 arginine/serine-rich coiled-coil 2 0.00711118
DDB2 damage-specific DNA binding protein 2, 48kDa 0.00707763
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.00703513
COG6 component of oligomeric golgi complex 6 0.00699194
GLCE glucuronic acid epimerase 0.00691771
NBAS neuroblastoma amplified sequence 0.00691097
TET2 tet methylcytosine dioxygenase 2 0.00689997
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.00689548
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00688498
FCHO2 FCH domain only 2 0.00686535
MED13L mediator complex subunit 13-like 0.00684731
SOS2 son of sevenless homolog 2 (Drosophila) 0.00684448
SKIC3 SKI3 subunit of superkiller complex 0.00681497
HELZ helicase with zinc finger 0.00678572
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00677771
ANO6 anoctamin 6 0.00673867
LMAN1 lectin, mannose-binding, 1 0.00659068
ETNK1 ethanolamine kinase 1 0.00655438
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00652186
RAB18 RAB18, member RAS oncogene family 0.00648039
USP24 ubiquitin specific peptidase 24 0.00645553
PCNX1 pecanex 1 0.00644385
PTCH1 patched 1 0.00643474
USP25 ubiquitin specific peptidase 25 0.00639499
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.00638073
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.00637722
WDR41 WD repeat domain 41 0.0063582
PGM3 phosphoglucomutase 3 0.00631275
NEBL nebulette 0.00627451
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.00627273
BCLAF1 BCL2-associated transcription factor 1 0.00626657
CLINT1 clathrin interactor 1 0.00623081
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0061956
CSNK1G3 casein kinase 1, gamma 3 0.00613894
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.00611797
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00611207
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.00610787

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.289575
PTMA prothymosin, alpha -0.275024
TMSB10 thymosin beta 10 -0.226435
TPT1 tumor protein, translationally-controlled 1 -0.126094
RPS6 ribosomal protein S6 -0.121758
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.107777
RPS8 ribosomal protein S8 -0.0891142
S100A6 S100 calcium binding protein A6 -0.0749341
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0741015
RPS12 ribosomal protein S12 -0.0739104
NPSR1 neuropeptide S receptor 1 -0.0731771
RPL23 ribosomal protein L23 -0.0731553
RPL35A ribosomal protein L35a -0.0730606
RPS19 ribosomal protein S19 -0.0730025
RPS27A ribosomal protein S27a -0.0724402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0702713
RPLP1 ribosomal protein, large, P1 -0.0684015
FTL ferritin, light polypeptide -0.0681158
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0664268
RPL12 ribosomal protein L12 -0.0639265
PKM pyruvate kinase, muscle -0.0628106
RPL9 ribosomal protein L9 -0.0622564
RPLP2 ribosomal protein, large, P2 -0.0621912
RPS3 ribosomal protein S3 -0.0617841
ACTG1 actin gamma 1 -0.0609184
KRT8 keratin 8, type II -0.0606201
RPL34 ribosomal protein L34 -0.0603128
KRT18 keratin 18, type I -0.0585783
ITGA6 integrin, alpha 6 -0.0583222
EEF2 eukaryotic translation elongation factor 2 -0.0572827
RPL37A ribosomal protein L37a -0.0561692
ENO1 enolase 1, (alpha) -0.0560673
UBC ubiquitin C -0.0535302
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0517137
RPL19 ribosomal protein L19 -0.0510784
RPL36 ribosomal protein L36 -0.0510644
RPL26 ribosomal protein L26 -0.0499807
MT2A metallothionein 2A -0.0494095
NALF1 NALCN channel auxiliary factor 1 -0.0486489
RPS23 ribosomal protein S23 -0.0479365
TPM4 tropomyosin 4 -0.0468462
RPL8 ribosomal protein L8 -0.0466504
ACTN4 actinin, alpha 4 -0.0466229
RPL31 ribosomal protein L31 -0.0448105
LOC102724023 ES1 protein homolog, mitochondrial -0.0444939
AREG amphiregulin -0.0444271
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0443975
S100A10 S100 calcium binding protein A10 -0.0438596
RPS25 ribosomal protein S25 -0.0438519
AHNAK AHNAK nucleoprotein -0.0430095
RPS24 ribosomal protein S24 -0.0427945
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424154
RPL11 ribosomal protein L11 -0.0423651
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0422682
RPL5 ribosomal protein L5 -0.0422038
RPL7A ribosomal protein L7a -0.0421354
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0415606
ANXA2 annexin A2 -0.0414947
RPLP0 ribosomal protein, large, P0 -0.0414071
RPL18 ribosomal protein L18 -0.0408363
ONECUT3 one cut homeobox 3 -0.0404448
S100A9 S100 calcium binding protein A9 -0.0403107
LDHA lactate dehydrogenase A -0.0399706
ALCAM activated leukocyte cell adhesion molecule -0.0399552
RPS29 ribosomal protein S29 -0.0396211
MYO1E myosin IE -0.0395565
EPCAM epithelial cell adhesion molecule -0.0395503
RPS11 ribosomal protein S11 -0.0389081
PGK1 phosphoglycerate kinase 1 -0.0388678
RPS14 ribosomal protein S14 -0.0379828
RPL32 ribosomal protein L32 -0.0376867
RPS13 ribosomal protein S13 -0.0374354
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0361406
ASPH aspartate beta-hydroxylase -0.0351985
RPS27 ribosomal protein S27 -0.0346091
POTEF POTE ankyrin domain family, member F -0.0343267
HMGA1 high mobility group AT-hook 1 -0.0337543
TPI1 triosephosphate isomerase 1 -0.0337488
S100P S100 calcium binding protein P -0.0333441
RPS17 ribosomal protein S17 -0.0332309
EIF1 eukaryotic translation initiation factor 1 -0.0327063
RPS21 ribosomal protein S21 -0.0322751
GREB1L growth regulation by estrogen in breast cancer-like -0.0322059
NDRG1 N-myc downstream regulated 1 -0.0321244
RACK1 receptor for activated C kinase 1 -0.032112
RPL28 ribosomal protein L28 -0.0320976
RPS5 ribosomal protein S5 -0.0314071
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0312816
RPL7 ribosomal protein L7 -0.0311987
KRT19 keratin 19, type I -0.0308178
LMNA lamin A/C -0.0306892
RPL37 ribosomal protein L37 -0.0300982
TFF3 trefoil factor 3 (intestinal) -0.0298062
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0297163
EZR ezrin -0.0294618
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0294416
CALR calreticulin -0.0293153
FLNB filamin B, beta -0.0292762
IER3 immediate early response 3 -0.0289998
RPL15 ribosomal protein L15 -0.0286942