Silodosin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Silodosin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.139371
PSD3 pleckstrin and Sec7 domain containing 3 0.115532
ERRFI1 ERBB receptor feedback inhibitor 1 0.112282
TXNRD1 thioredoxin reductase 1 0.0816715
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0772427
MACF1 microtubule-actin crosslinking factor 1 0.0717139
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0710633
TM4SF1 transmembrane 4 L six family member 1 0.0660339
AHNAK AHNAK nucleoprotein 0.0659551
TP63 tumor protein p63 0.0629901
APP amyloid beta (A4) precursor protein 0.0612281
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0545072
STAT1 signal transducer and activator of transcription 1, 91kDa 0.051006
TSC22D1 TSC22 domain family, member 1 0.0498491
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0466693
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0463477
FMNL2 formin-like 2 0.0444194
DPYD dihydropyrimidine dehydrogenase 0.0430423
CD44 CD44 molecule (Indian blood group) 0.042532
EREG epiregulin 0.0419273
EMP1 epithelial membrane protein 1 0.0416303
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0403383
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0386456
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0386241
BCAR3 breast cancer anti-estrogen resistance 3 0.0383586
RAB27B RAB27B, member RAS oncogene family 0.0380313
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.03734
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0361693
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0359812
BIRC2 baculoviral IAP repeat containing 2 0.0356463
TMSB4X thymosin beta 4, X-linked 0.0354854
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0346949
BIRC6 baculoviral IAP repeat containing 6 0.0336236
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0334089
WDR26 WD repeat domain 26 0.0333302
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0329586
HSPA8 heat shock 70kDa protein 8 0.0329236
CAPRIN2 caprin family member 2 0.0326158
TTC28 tetratricopeptide repeat domain 28 0.0322812
USP9X ubiquitin specific peptidase 9, X-linked 0.0321713
VMP1 vacuole membrane protein 1 0.0320969
SPIDR scaffolding protein involved in DNA repair 0.0317379
NPAS2 neuronal PAS domain protein 2 0.0313903
ADGRG6 adhesion G protein-coupled receptor G6 0.0311695
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0309155
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0308411
SOD2 superoxide dismutase 2, mitochondrial 0.030721
ARHGAP5 Rho GTPase activating protein 5 0.0306512
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0306363
ZMYND8 zinc finger, MYND-type containing 8 0.0306107
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0305654
WWTR1 WW domain containing transcription regulator 1 0.0304595
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0291145
GCLM glutamate-cysteine ligase, modifier subunit 0.0285374
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0284544
BZW1 basic leucine zipper and W2 domains 1 0.028355
ZEB1 zinc finger E-box binding homeobox 1 0.0281197
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0275218
TXNIP thioredoxin interacting protein 0.0267361
DENND5A DENN/MADD domain containing 5A 0.0266853
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0266384
CANX calnexin 0.0266011
RAD51B RAD51 paralog B 0.0265259
CDK6 cyclin-dependent kinase 6 0.0264545
RBM39 RNA binding motif protein 39 0.0264247
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0261533
XPO1 exportin 1 0.026136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0257877
HDLBP high density lipoprotein binding protein 0.0256942
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.025557
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252608
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0245849
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0245767
OGA O-GlcNAcase 0.0244993
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0244551
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0241254
ANTXR2 anthrax toxin receptor 2 0.0241021
EZR ezrin 0.023913
SFPQ splicing factor proline/glutamine-rich 0.0235846
SERINC1 serine incorporator 1 0.023563
ANKRD12 ankyrin repeat domain 12 0.0234815
ERBIN erbb2 interacting protein 0.0233078
USP34 ubiquitin specific peptidase 34 0.0232073
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0231337
SMYD3 SET and MYND domain containing 3 0.0229887
KPNB1 karyopherin (importin) beta 1 0.0229657
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0228492
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0224357
RIGI RNA sensor RIG-I 0.0223128
THSD4 thrombospondin, type I, domain containing 4 0.022144
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0218805
MYO10 myosin X 0.021822
KMT2E lysine (K)-specific methyltransferase 2E 0.0218167
COL5A2 collagen, type V, alpha 2 0.0218096
ZFAND3 zinc finger, AN1-type domain 3 0.0217606
BRWD3 bromodomain and WD repeat domain containing 3 0.0217445
ANKHD1 ankyrin repeat and KH domain containing 1 0.0215673
TOP2B topoisomerase (DNA) II beta 180kDa 0.0211072
ATP13A3 ATPase type 13A3 0.0210529
ZC3H11A zinc finger CCCH-type containing 11A 0.0210181

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.217754
MT2A metallothionein 2A -0.171071
VIM vimentin -0.160295
TMSB10 thymosin beta 10 -0.131796
POTEF POTE ankyrin domain family, member F -0.108375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0830648
FTL ferritin, light polypeptide -0.0794496
RPL35A ribosomal protein L35a -0.0782205
RPL37A ribosomal protein L37a -0.0659422
RPS6 ribosomal protein S6 -0.0641466
RPL23 ribosomal protein L23 -0.0597433
RPS8 ribosomal protein S8 -0.0586438
RPS3 ribosomal protein S3 -0.0568508
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0547113
RPS12 ribosomal protein S12 -0.0530337
HMGA1 high mobility group AT-hook 1 -0.0524936
RPS19 ribosomal protein S19 -0.049274
ZFP36L1 ZFP36 ring finger protein-like 1 -0.04513
RPLP2 ribosomal protein, large, P2 -0.0405435
TPI1 triosephosphate isomerase 1 -0.0402756
RPL12 ribosomal protein L12 -0.0399819
ENO2 enolase 2 (gamma, neuronal) -0.0381753
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0379816
IFITM1 interferon induced transmembrane protein 1 -0.0362699
PFN1 profilin 1 -0.0356954
RPL26 ribosomal protein L26 -0.0355683
RPL18 ribosomal protein L18 -0.03514
B2M beta-2-microglobulin -0.0350146
RPL31 ribosomal protein L31 -0.0347062
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0342414
YBX1 Y box binding protein 1 -0.0334793
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0310981
RPL7A ribosomal protein L7a -0.030762
EGR1 early growth response 1 -0.0302647
EIF1 eukaryotic translation initiation factor 1 -0.0294095
NAP1L1 nucleosome assembly protein 1-like 1 -0.0289897
RACK1 receptor for activated C kinase 1 -0.028815
EEF1G eukaryotic translation elongation factor 1 gamma -0.0288055
RPL35 ribosomal protein L35 -0.0283565
RPS25 ribosomal protein S25 -0.0276848
FOSL1 FOS-like antigen 1 -0.027145
FTH1 ferritin, heavy polypeptide 1 -0.0268103
DLG1 discs, large homolog 1 (Drosophila) -0.0267158
RAB7A RAB7A, member RAS oncogene family -0.026483
S100A9 S100 calcium binding protein A9 -0.0264075
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0263192
RPL28 ribosomal protein L28 -0.0262388
RPL36 ribosomal protein L36 -0.0256244
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.025163
DDIT4 DNA-damage-inducible transcript 4 -0.0250448
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0249221
SRGN serglycin -0.0245466
BRD2 bromodomain containing 2 -0.0244347
RPS27 ribosomal protein S27 -0.0242545
IFITM3 interferon induced transmembrane protein 3 -0.0235272
NUCB2 nucleobindin 2 -0.0234094
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0233631
GNAS GNAS complex locus -0.0233294
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0231064
HILPDA hypoxia inducible lipid droplet-associated -0.023088
NDRG1 N-myc downstream regulated 1 -0.0230527
EEF2 eukaryotic translation elongation factor 2 -0.0224401
LOC102724023 ES1 protein homolog, mitochondrial -0.0218864
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0217718
MT1E metallothionein 1E -0.0215074
ANXA2 annexin A2 -0.0212293
PIAS2 protein inhibitor of activated STAT, 2 -0.0211913
MYADM myeloid-associated differentiation marker -0.0211316
RPL37 ribosomal protein L37 -0.0211008
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0209588
TSC22D2 TSC22 domain family, member 2 -0.0209063
S100A11 S100 calcium binding protein A11 -0.0207195
RPS17 ribosomal protein S17 -0.0205235
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0205124
ATF4 activating transcription factor 4 -0.0203499
RPS13 ribosomal protein S13 -0.0201539
KTN1 kinectin 1 (kinesin receptor) -0.019646
PKM pyruvate kinase, muscle -0.0192534
HSPG2 heparan sulfate proteoglycan 2 -0.0191903
GOLGA4 golgin A4 -0.0190213
PDIA3 protein disulfide isomerase family A, member 3 -0.0189406
RPL27 ribosomal protein L27 -0.0184968
HDGF hepatoma-derived growth factor -0.0183206
CALR calreticulin -0.0182446
IFI6 interferon, alpha-inducible protein 6 -0.0181826
RPL9 ribosomal protein L9 -0.0180948
SMIM44 small integral membrane protein 44 -0.0180399
SRSF11 serine/arginine-rich splicing factor 11 -0.0178518
RPL36A ribosomal protein L36a -0.0178296
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.017747
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0177435
PTPRF protein tyrosine phosphatase, receptor type, F -0.0176145
AKAP9 A kinase (PRKA) anchor protein 9 -0.0174664
ATN1 atrophin 1 -0.0174219
CCNL1 cyclin L1 -0.0173308
RPLP1 ribosomal protein, large, P1 -0.0169555
BSG basigin (Ok blood group) -0.0168642
HLA-A major histocompatibility complex, class I, A -0.0167968
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0166646
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0164985