Silodosin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.0701462
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0565594
FTH1 ferritin, heavy polypeptide 1 0.0552422
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0478019
SOD2 superoxide dismutase 2, mitochondrial 0.0476076
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0473208
CES1 carboxylesterase 1 0.0392947
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0377012
FAM13A family with sequence similarity 13, member A 0.0269578
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0257016
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0251514
NGLY1 N-glycanase 1 0.02413
GCLC glutamate-cysteine ligase, catalytic subunit 0.0215793
ZNF638 zinc finger protein 638 0.0197722
SP3 Sp3 transcription factor 0.018518
ZC3H11A zinc finger CCCH-type containing 11A 0.0158618
ATP11A ATPase, class VI, type 11A 0.0158566
TMEM165 transmembrane protein 165 0.0156689
EIF4B eukaryotic translation initiation factor 4B 0.0135894
WDFY3 WD repeat and FYVE domain containing 3 0.0129693
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0128033
PCBP2 poly(rC) binding protein 2 0.012571
CEMIP cell migration inducing protein, hyaluronan binding 0.0123712
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0121299
TMEM45B transmembrane protein 45B 0.0120153
ZFC3H1 zinc finger, C3H1-type containing 0.0117965
MKI67 marker of proliferation Ki-67 0.0116675
RNF217 ring finger protein 217 0.0115975
LGALS12 lectin, galactoside-binding, soluble, 12 0.0115748
BRWD1 bromodomain and WD repeat domain containing 1 0.0110037
BIRC3 baculoviral IAP repeat containing 3 0.0108422
N4BP2 NEDD4 binding protein 2 0.010775
USP9X ubiquitin specific peptidase 9, X-linked 0.0107708
WDR26 WD repeat domain 26 0.0106897
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0105046
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0104436
ALPK1 alpha-kinase 1 0.0103905
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0102645
NPAS2 neuronal PAS domain protein 2 0.0100779
LRP1B low density lipoprotein receptor-related protein 1B 0.0100749
MED13 mediator complex subunit 13 0.0100649
CYTH1 cytohesin 1 0.0100572
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.010039
APLP2 amyloid beta (A4) precursor-like protein 2 0.00993017
CD109 CD109 molecule 0.00975034
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.00949136
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00930323
TENT5A terminal nucleotidyltransferase 5A 0.00923976
CEP192 centrosomal protein 192kDa 0.00917631
ZBTB1 zinc finger and BTB domain containing 1 0.00907067
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.00877653
FRY furry homolog (Drosophila) 0.00860411
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.00859537
ATP13A3 ATPase type 13A3 0.00850607
TBK1 TANK-binding kinase 1 0.00845776
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00837349
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.00830469
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.00824521
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0082335
MIDEAS mitotic deacetylase associated SANT domain protein 0.00822574
MARF1 meiosis regulator and mRNA stability factor 1 0.00815762
NDE1 nudE neurodevelopment protein 1 0.00808497
ATAD2B ATPase family, AAA domain containing 2B 0.0080372
JARID2 jumonji, AT rich interactive domain 2 0.00801906
PTPRM protein tyrosine phosphatase, receptor type, M 0.00795054
CAMTA1 calmodulin binding transcription activator 1 0.00794015
BLTP1 bridge-like lipid transfer protein family member 1 0.00793112
ECT2 epithelial cell transforming 2 0.00789704
ATG7 autophagy related 7 0.00787648
C1D C1D nuclear receptor corepressor 0.00784305
SHB Src homology 2 domain containing adaptor protein B 0.00783534
METTL9 methyltransferase like 9 0.00782675
SS18 synovial sarcoma translocation, chromosome 18 0.00779412
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.00774823
FRYL FRY-like 0.00771246
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00761111
ATXN1 ataxin 1 0.00758095
DSPP dentin sialophosphoprotein 0.00754696
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00747015
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00745923
NIBAN2 niban apoptosis regulator 2 0.00744227
XDH xanthine dehydrogenase 0.00742915
HAPSTR1 HUWE1 associated protein modifying stress responses 0.00742152
RAD21 RAD21 homolog (S. pombe) 0.00734582
ZNF292 zinc finger protein 292 0.00733466
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.00733195
FNDC3B fibronectin type III domain containing 3B 0.00731416
RPN1 ribophorin I 0.00726437
TP53BP1 tumor protein p53 binding protein 1 0.00725683
YY1AP1 YY1 associated protein 1 0.00724302
USP24 ubiquitin specific peptidase 24 0.00723735
SMTN smoothelin 0.00722976
CDC42SE2 CDC42 small effector 2 0.0072233
LRRC8C leucine rich repeat containing 8 family, member C 0.0072018
ARID4A AT rich interactive domain 4A (RBP1-like) 0.00717578
KIF14 kinesin family member 14 0.00715353
SEC16A SEC16 homolog A (S. cerevisiae) 0.00715197
DNER delta/notch-like EGF repeat containing 0.00715119
GRB10 growth factor receptor-bound protein 10 0.00715076
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00711977

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.413609
TMSB10 thymosin beta 10 -0.133343
NDRG1 N-myc downstream regulated 1 -0.106841
FTL ferritin, light polypeptide -0.0995714
MT2A metallothionein 2A -0.096396
TPT1 tumor protein, translationally-controlled 1 -0.0920869
RPS3 ribosomal protein S3 -0.0809321
LAMC2 laminin, gamma 2 -0.067721
EGR1 early growth response 1 -0.063104
PKM pyruvate kinase, muscle -0.0599169
PTMA prothymosin, alpha -0.05969
RPL35A ribosomal protein L35a -0.056463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.05545
RPS25 ribosomal protein S25 -0.0543575
LMO7 LIM domain 7 -0.0537744
RPL37A ribosomal protein L37a -0.0537338
ANXA2 annexin A2 -0.0530074
RPS6 ribosomal protein S6 -0.0508304
SEC61G Sec61 gamma subunit -0.0502439
RPLP1 ribosomal protein, large, P1 -0.0498451
RPS8 ribosomal protein S8 -0.0487035
S100A10 S100 calcium binding protein A10 -0.0474421
ACTG1 actin gamma 1 -0.0432482
RPS12 ribosomal protein S12 -0.0430681
B2M beta-2-microglobulin -0.0419012
SLC38A1 solute carrier family 38, member 1 -0.0418623
JMJD1C jumonji domain containing 1C -0.0417987
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.041202
RPL34 ribosomal protein L34 -0.0402875
CAV1 caveolin 1, caveolae protein, 22kDa -0.0400174
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0395798
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0394015
CST3 cystatin C -0.0380368
RPL31 ribosomal protein L31 -0.0380219
RPS27A ribosomal protein S27a -0.0373265
EIF1 eukaryotic translation initiation factor 1 -0.0366294
RPL12 ribosomal protein L12 -0.036545
RPS24 ribosomal protein S24 -0.0362676
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0353414
RAB7A RAB7A, member RAS oncogene family -0.0346779
DSCAM Down syndrome cell adhesion molecule -0.0345344
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0337973
RPL11 ribosomal protein L11 -0.0333107
TXNRD1 thioredoxin reductase 1 -0.0326326
RPL19 ribosomal protein L19 -0.0325241
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0324216
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0323133
RPLP2 ribosomal protein, large, P2 -0.0314953
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0310528
WSB1 WD repeat and SOCS box containing 1 -0.0304455
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0303284
MCTP1 multiple C2 domains, transmembrane 1 -0.0301887
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0299296
MCL1 myeloid cell leukemia 1 -0.0298182
CCNL1 cyclin L1 -0.0297929
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0296978
RPL5 ribosomal protein L5 -0.0295636
MYOF myoferlin -0.028681
RPS27 ribosomal protein S27 -0.0285514
RPS23 ribosomal protein S23 -0.0284149
TJP1 tight junction protein 1 -0.0280639
NSUN6 NOP2/Sun domain family, member 6 -0.0277417
RPS29 ribosomal protein S29 -0.0277083
HLA-B major histocompatibility complex, class I, B -0.0275611
RPL8 ribosomal protein L8 -0.026928
RPS19 ribosomal protein S19 -0.0269209
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0268734
GRAMD1B GRAM domain containing 1B -0.0268041
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0266282
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0265281
STC1 stanniocalcin 1 -0.0264652
IER3 immediate early response 3 -0.0264439
RPLP0 ribosomal protein, large, P0 -0.025981
RPS17 ribosomal protein S17 -0.0257092
MYO1E myosin IE -0.0254963
WASF2 WAS protein family, member 2 -0.0254106
RPL37 ribosomal protein L37 -0.0254073
RPL7 ribosomal protein L7 -0.0250733
RACK1 receptor for activated C kinase 1 -0.0246108
AKAP9 A kinase (PRKA) anchor protein 9 -0.0244807
GNAS GNAS complex locus -0.0243423
RPL23 ribosomal protein L23 -0.0242619
ENO1 enolase 1, (alpha) -0.023642
AKR1C1 aldo-keto reductase family 1, member C1 -0.0235642
CCNI cyclin I -0.0235071
RPS14 ribosomal protein S14 -0.0233968
SPAG9 sperm associated antigen 9 -0.0233487
RPL9 ribosomal protein L9 -0.0232967
GOLGA4 golgin A4 -0.0231323
NAP1L1 nucleosome assembly protein 1-like 1 -0.0230816
TPD52 tumor protein D52 -0.0230295
RPL30 ribosomal protein L30 -0.0229879
DTNA dystrobrevin, alpha -0.0228381
USP53 ubiquitin specific peptidase 53 -0.02267
AREG amphiregulin -0.0225489
RPL36 ribosomal protein L36 -0.0224553
SETD5 SET domain containing 5 -0.0224512
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0224361
PDIA3 protein disulfide isomerase family A, member 3 -0.0223941
BLZF1 basic leucine zipper nuclear factor 1 -0.0223793