| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Silodosin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Silodosin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.122832 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0914763 |
| PGK1 | phosphoglycerate kinase 1 | 0.0787873 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0739808 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0736652 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0727316 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0647865 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0549878 |
| PTMA | prothymosin, alpha | 0.0519929 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0516018 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0510145 |
| SETD5 | SET domain containing 5 | 0.0507039 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0489108 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0487376 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0481738 |
| TGFB1 | transforming growth factor, beta 1 | 0.0473286 |
| SYT1 | synaptotagmin I | 0.0471627 |
| ENO1 | enolase 1, (alpha) | 0.045243 |
| OXR1 | oxidation resistance 1 | 0.0451496 |
| APP | amyloid beta (A4) precursor protein | 0.044395 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0443168 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0442985 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0441339 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0430942 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0430117 |
| WWOX | WW domain containing oxidoreductase | 0.0424583 |
| MSN | moesin | 0.0420092 |
| MYO10 | myosin X | 0.041858 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0411175 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0409076 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0400866 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0398854 |
| WDR43 | WD repeat domain 43 | 0.0395231 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0393371 |
| RUNX1 | runt-related transcription factor 1 | 0.0393368 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0393052 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0388432 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0385274 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0381542 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0378384 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0376747 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0376196 |
| RPL36A | ribosomal protein L36a | 0.0369801 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0365171 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.036141 |
| RPL37A | ribosomal protein L37a | 0.0355986 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0353943 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0353866 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0351534 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0347448 |
| ITGA6 | integrin, alpha 6 | 0.0344171 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0336695 |
| ZNF148 | zinc finger protein 148 | 0.0336347 |
| MED13L | mediator complex subunit 13-like | 0.0333194 |
| RPS3 | ribosomal protein S3 | 0.0333088 |
| SET | SET nuclear proto-oncogene | 0.0332256 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0329211 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0329131 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0328248 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0322175 |
| RPS12 | ribosomal protein S12 | 0.03218 |
| PHKB | phosphorylase kinase, beta | 0.0320795 |
| ETNK1 | ethanolamine kinase 1 | 0.0320485 |
| BBX | bobby sox homolog (Drosophila) | 0.032008 |
| HELZ | helicase with zinc finger | 0.0318851 |
| TMEM14B | transmembrane protein 14B | 0.0317005 |
| RAN | RAN, member RAS oncogene family | 0.0316998 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.031595 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0315775 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0312758 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0312493 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0310902 |
| TUBA1B | tubulin, alpha 1b | 0.0310623 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0310431 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0309353 |
| RPS13 | ribosomal protein S13 | 0.0308606 |
| TMEM178B | transmembrane protein 178B | 0.0307597 |
| NRG1 | neuregulin 1 | 0.030671 |
| PNN | pinin, desmosome associated protein | 0.0305899 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0302826 |
| ANAPC5 | anaphase promoting complex subunit 5 | 0.0302234 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.030192 |
| PTK2 | protein tyrosine kinase 2 | 0.0301487 |
| RPL11 | ribosomal protein L11 | 0.0301432 |
| FNBP4 | formin binding protein 4 | 0.0301303 |
| FOXJ3 | forkhead box J3 | 0.0300494 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0298497 |
| EXOC4 | exocyst complex component 4 | 0.0297213 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.0297188 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0296602 |
| KPNA6 | karyopherin alpha 6 (importin alpha 7) | 0.0296273 |
| CCDC47 | coiled-coil domain containing 47 | 0.029566 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0295248 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0293549 |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | 0.0293256 |
| RPL7 | ribosomal protein L7 | 0.0292465 |
| VCL | vinculin | 0.0291933 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0290445 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0290192 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0289699 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.205056 |
| MYO1E | myosin IE | -0.183534 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.172236 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.152801 |
| KRT17 | keratin 17, type I | -0.142941 |
| GRB10 | growth factor receptor-bound protein 10 | -0.131188 |
| LMO7 | LIM domain 7 | -0.129433 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.128209 |
| MUC16 | mucin 16, cell surface associated | -0.121668 |
| LAMB3 | laminin, beta 3 | -0.118948 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.118203 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.115166 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.109777 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.104051 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.103111 |
| ATOSA | atos homolog A | -0.0947647 |
| SVIL | supervillin | -0.0934757 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0917958 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0891491 |
| KYNU | kynureninase | -0.0874017 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0820803 |
| NDRG1 | N-myc downstream regulated 1 | -0.0749166 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0724885 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0720198 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0698136 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0687743 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0684069 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0674722 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0664834 |
| ANXA2 | annexin A2 | -0.0639636 |
| TJP1 | tight junction protein 1 | -0.0636561 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0630003 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0616149 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0615342 |
| STC1 | stanniocalcin 1 | -0.0607221 |
| CMIP | c-Maf inducing protein | -0.0588695 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0579924 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0563531 |
| ABHD17C | abhydrolase domain containing 17C | -0.0563059 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0556232 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0549656 |
| ERBIN | erbb2 interacting protein | -0.053214 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0530434 |
| SLMAP | sarcolemma associated protein | -0.0529976 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0507113 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.050484 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.050426 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0503373 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0501689 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0493236 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0491498 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0476636 |
| MYO5B | myosin VB | -0.0473602 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0469671 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0464986 |
| ACTG1 | actin gamma 1 | -0.0461337 |
| JUP | junction plakoglobin | -0.0451909 |
| MCL1 | myeloid cell leukemia 1 | -0.044871 |
| LAMC2 | laminin, gamma 2 | -0.0446315 |
| EZR | ezrin | -0.0439239 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0432543 |
| ABLIM1 | actin binding LIM protein 1 | -0.0430765 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.042386 |
| RND3 | Rho family GTPase 3 | -0.0423371 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0423239 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0421551 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0418863 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0415273 |
| RBM47 | RNA binding motif protein 47 | -0.0414909 |
| TUFT1 | tuftelin 1 | -0.0413397 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0411992 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0405582 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0401848 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0395292 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0393248 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0391205 |
| PTEN | phosphatase and tensin homolog | -0.0385796 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0383394 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0382985 |
| S100A9 | S100 calcium binding protein A9 | -0.0376437 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0376053 |
| FNIP1 | folliculin interacting protein 1 | -0.0369713 |
| CA12 | carbonic anhydrase XII | -0.0368987 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0368683 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0361807 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0361488 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0355104 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0352748 |
| TMEM165 | transmembrane protein 165 | -0.0352631 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0351367 |
| FOXO1 | forkhead box O1 | -0.0349892 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0348824 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0348433 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0347147 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0342409 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0342112 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0342084 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0337392 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0336134 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0336053 |
