Silodosin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.138018
GRAMD1B GRAM domain containing 1B 0.0959806
RAD51B RAD51 paralog B 0.0942942
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0791811
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0690341
ERRFI1 ERBB receptor feedback inhibitor 1 0.0613082
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0583599
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0582615
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0565133
XPO1 exportin 1 0.0557879
TAS2R14 taste receptor, type 2, member 14 0.0489434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0441856
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0431919
AKAP12 A kinase (PRKA) anchor protein 12 0.0430504
EXOC4 exocyst complex component 4 0.042858
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0417999
ENO1 enolase 1, (alpha) 0.0415228
MACF1 microtubule-actin crosslinking factor 1 0.0410952
THSD4 thrombospondin, type I, domain containing 4 0.0408904
DST dystonin 0.039479
CENPF centromere protein F, 350/400kDa 0.0393726
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0365886
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0362503
SMYD3 SET and MYND domain containing 3 0.0350946
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0349366
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0342937
TFPI2 tissue factor pathway inhibitor 2 0.0328965
ANKRD36 ankyrin repeat domain 36 0.0327213
HSPA8 heat shock 70kDa protein 8 0.0319694
MED13L mediator complex subunit 13-like 0.0312831
PUM2 pumilio RNA-binding family member 2 0.0311969
SMAD3 SMAD family member 3 0.0311782
CSDE1 cold shock domain containing E1, RNA-binding 0.030741
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0305882
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0304212
TRIO trio Rho guanine nucleotide exchange factor 0.0302441
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0294704
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0292585
SP3 Sp3 transcription factor 0.0292521
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0292506
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0289126
IGF1R insulin-like growth factor 1 receptor 0.0285943
NIPBL Nipped-B homolog (Drosophila) 0.0284621
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0278507
TBC1D5 TBC1 domain family, member 5 0.0277982
ZNF292 zinc finger protein 292 0.0273896
NCOR1 nuclear receptor corepressor 1 0.0273069
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272673
APP amyloid beta (A4) precursor protein 0.0272099
NUP153 nucleoporin 153kDa 0.0266342
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0263067
SINHCAF SIN3-HDAC complex associated factor 0.0260427
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0259928
TPM3 tropomyosin 3 0.0255798
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0249372
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0248653
AFG2A AFG2 AAA ATPase homolog A 0.024806
GPHN gephyrin 0.024485
PHIP pleckstrin homology domain interacting protein 0.0243596
BABAM2 BRISC and BRCA1 A complex member 2 0.0242696
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.024225
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0241218
SMC4 structural maintenance of chromosomes 4 0.0240665
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0238606
BRCA1 breast cancer 1, early onset 0.0237958
TM4SF1 transmembrane 4 L six family member 1 0.023763
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0236863
EPN2 epsin 2 0.0236581
BBX bobby sox homolog (Drosophila) 0.0236326
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0235023
TXNRD1 thioredoxin reductase 1 0.0234404
USP24 ubiquitin specific peptidase 24 0.023353
EIF4B eukaryotic translation initiation factor 4B 0.0232868
BTBD9 BTB (POZ) domain containing 9 0.0231262
TMEM131 transmembrane protein 131 0.0230034
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0229759
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0229517
IL6ST interleukin 6 signal transducer 0.022501
AHNAK AHNAK nucleoprotein 0.0224035
WDR70 WD repeat domain 70 0.0223444
NUP155 nucleoporin 155kDa 0.0223013
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0221995
NAMPT nicotinamide phosphoribosyltransferase 0.0221055
ANXA5 annexin A5 0.0218802
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0217555
U2SURP U2 snRNP-associated SURP domain containing 0.0217017
DOCK3 dedicator of cytokinesis 3 0.0216893
PHF3 PHD finger protein 3 0.0215677
TMPO thymopoietin 0.0215523
MATR3 matrin 3 0.0215438
SPIDR scaffolding protein involved in DNA repair 0.0214091
CLTC clathrin, heavy chain (Hc) 0.0213389
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.021297
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0210764
YAP1 Yes-associated protein 1 0.0210177
STAG2 stromal antigen 2 0.0207865
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0207812
MKI67 marker of proliferation Ki-67 0.0207796
PDE4D phosphodiesterase 4D, cAMP-specific 0.020724
SENP6 SUMO1/sentrin specific peptidase 6 0.0206462

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233737
EGR1 early growth response 1 -0.0964078
VIM vimentin -0.070192
TMSB10 thymosin beta 10 -0.0655007
RPS3 ribosomal protein S3 -0.0566036
YBX3 Y box binding protein 3 -0.0563946
RPL35A ribosomal protein L35a -0.0528236
RPL37A ribosomal protein L37a -0.0496317
RPS8 ribosomal protein S8 -0.0469077
PFN1 profilin 1 -0.0466206
RPL12 ribosomal protein L12 -0.0442558
RAB7A RAB7A, member RAS oncogene family -0.0433889
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0422023
RPS27 ribosomal protein S27 -0.0409889
OSMR oncostatin M receptor -0.0402405
RPS12 ribosomal protein S12 -0.0396107
MT2A metallothionein 2A -0.0389385
RPL26 ribosomal protein L26 -0.0373624
TPT1 tumor protein, translationally-controlled 1 -0.0366371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.035844
ACTN1 actinin, alpha 1 -0.0343692
RPS19 ribosomal protein S19 -0.0339138
RPL23 ribosomal protein L23 -0.0334532
PTMA prothymosin, alpha -0.0325386
RPS29 ribosomal protein S29 -0.0307196
FTL ferritin, light polypeptide -0.0307174
TPM2 tropomyosin 2 (beta) -0.0304797
LOC102724023 ES1 protein homolog, mitochondrial -0.0302279
RPS6 ribosomal protein S6 -0.0301865
RPL36 ribosomal protein L36 -0.029503
RPLP1 ribosomal protein, large, P1 -0.0289995
POTEF POTE ankyrin domain family, member F -0.0286987
RPL32 ribosomal protein L32 -0.0284566
RPS25 ribosomal protein S25 -0.0275531
RPL37 ribosomal protein L37 -0.0273998
EEF2 eukaryotic translation elongation factor 2 -0.0273128
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0270734
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0269025
COPA coatomer protein complex, subunit alpha -0.0265195
GNAS GNAS complex locus -0.0253867
RPL28 ribosomal protein L28 -0.0251516
RPS27A ribosomal protein S27a -0.0250324
RPLP2 ribosomal protein, large, P2 -0.0248321
RPL18 ribosomal protein L18 -0.0248295
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0240513
RPL19 ribosomal protein L19 -0.0238967
TPI1 triosephosphate isomerase 1 -0.023861
VCL vinculin -0.0232428
EIF1 eukaryotic translation initiation factor 1 -0.0230767
ACTG1 actin gamma 1 -0.0230581
RPL35 ribosomal protein L35 -0.0215728
RPL27A ribosomal protein L27a -0.0214932
RPL27 ribosomal protein L27 -0.0213073
RPS10 ribosomal protein S10 -0.0211025
IER3 immediate early response 3 -0.0200077
WNT2B wingless-type MMTV integration site family, member 2B -0.0199917
RPS21 ribosomal protein S21 -0.0199624
NABP1 nucleic acid binding protein 1 -0.0197484
CCNL1 cyclin L1 -0.0194267
PDLIM5 PDZ and LIM domain 5 -0.0190939
RPS17 ribosomal protein S17 -0.0189661
IGF2 insulin-like growth factor 2 -0.0185036
RPL31 ribosomal protein L31 -0.0184704
WSB1 WD repeat and SOCS box containing 1 -0.0182018
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0180357
RPS16 ribosomal protein S16 -0.0179789
MEF2D myocyte enhancer factor 2D -0.0179615
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0178988
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0174624
GSTP1 glutathione S-transferase pi 1 -0.0174001
RACK1 receptor for activated C kinase 1 -0.0172917
RPLP0 ribosomal protein, large, P0 -0.0172341
RPL34 ribosomal protein L34 -0.0171237
WASF2 WAS protein family, member 2 -0.0168099
RPL8 ribosomal protein L8 -0.0167602
RPL36A ribosomal protein L36a -0.0165149
ZNF207 zinc finger protein 207 -0.0156634
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.01554
S100A11 S100 calcium binding protein A11 -0.0154089
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0153586
MCTP1 multiple C2 domains, transmembrane 1 -0.0153348
RPL9 ribosomal protein L9 -0.0152082
SEC61G Sec61 gamma subunit -0.0151167
DSCAM Down syndrome cell adhesion molecule -0.0149608
KDM6B lysine (K)-specific demethylase 6B -0.0148241
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.01448
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0144665
TUBA1C tubulin, alpha 1c -0.0144241
RAB22A RAB22A, member RAS oncogene family -0.0144159
KRT18 keratin 18, type I -0.0143863
SETD5 SET domain containing 5 -0.0143213
BRD4 bromodomain containing 4 -0.0141453
RPS11 ribosomal protein S11 -0.0139499
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0137404
RPL10A ribosomal protein L10a -0.0137365
MCL1 myeloid cell leukemia 1 -0.0136697
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0135702
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0135676
RAP1B RAP1B, member of RAS oncogene family -0.0134907
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.013058