Silodosin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.118759
FN1 fibronectin 1 0.10389
NAMPT nicotinamide phosphoribosyltransferase 0.082202
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0787113
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0774478
FNDC3B fibronectin type III domain containing 3B 0.0749891
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0653363
ELL2 elongation factor, RNA polymerase II, 2 0.0582607
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0576261
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0559274
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0529643
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0525182
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0485525
FXR1 fragile X mental retardation, autosomal homolog 1 0.0483127
PTK2 protein tyrosine kinase 2 0.0467221
TFG TRK-fused gene 0.0405053
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0400097
RAD21 RAD21 homolog (S. pombe) 0.0393854
FAM13A family with sequence similarity 13, member A 0.0391885
PCBP2 poly(rC) binding protein 2 0.0389282
GRB10 growth factor receptor-bound protein 10 0.0380592
CD47 CD47 molecule 0.0371054
MEF2A myocyte enhancer factor 2A 0.0369464
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0362381
ADAM9 ADAM metallopeptidase domain 9 0.0355203
NUP58 nucleoporin 58 0.0352868
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0342036
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0339001
NAV2 neuron navigator 2 0.0336765
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0332869
TXNRD1 thioredoxin reductase 1 0.0332483
MSN moesin 0.0331693
CD46 CD46 molecule, complement regulatory protein 0.0330929
ARRDC3 arrestin domain containing 3 0.0328615
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.032794
CHD1 chromodomain helicase DNA binding protein 1 0.0315763
PAPOLA poly(A) polymerase alpha 0.0304386
TSC22D2 TSC22 domain family, member 2 0.030315
GLS2 glutaminase 2 (liver, mitochondrial) 0.0299109
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0298746
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0296555
MATR3 matrin 3 0.0295948
MSMO1 methylsterol monooxygenase 1 0.02949
RNF145 ring finger protein 145 0.0292964
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0287797
NCKAP1 NCK-associated protein 1 0.0286608
IL6ST interleukin 6 signal transducer 0.0283303
KIAA1217 KIAA1217 0.0280713
CDC73 cell division cycle 73 0.0274308
TRIO trio Rho guanine nucleotide exchange factor 0.0273688
ZNF292 zinc finger protein 292 0.0271431
UBA6 ubiquitin-like modifier activating enzyme 6 0.0270588
MYH9 myosin, heavy chain 9, non-muscle 0.0270201
CCNL1 cyclin L1 0.0269839
QKI QKI, KH domain containing, RNA binding 0.0268561
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0262865
HSPA8 heat shock 70kDa protein 8 0.0255498
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0254364
USP9X ubiquitin specific peptidase 9, X-linked 0.0251095
WAC WW domain containing adaptor with coiled-coil 0.0247486
VMP1 vacuole membrane protein 1 0.0246519
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0242131
KDM6A lysine (K)-specific demethylase 6A 0.0240643
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0239611
GARS1 glycyl-tRNA synthetase 1 0.0238154
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0237576
ALCAM activated leukocyte cell adhesion molecule 0.0237096
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0236529
PEG10 paternally expressed 10 0.0236402
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0235067
ARL5B ADP-ribosylation factor-like 5B 0.0233892
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023239
CENPF centromere protein F, 350/400kDa 0.023084
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0229097
ECT2 epithelial cell transforming 2 0.0228764
FHIT fragile histidine triad 0.0226151
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0225309
IRF6 interferon regulatory factor 6 0.0224551
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0223408
USP3 ubiquitin specific peptidase 3 0.0223089
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0222563
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0221832
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0220884
ANXA5 annexin A5 0.0216408
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0215954
PGK1 phosphoglycerate kinase 1 0.0214992
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0214888
APLP2 amyloid beta (A4) precursor-like protein 2 0.0214888
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0213386
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0211597
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0210749
RICTOR RPTOR independent companion of MTOR, complex 2 0.0210264
MBNL1 muscleblind-like splicing regulator 1 0.0210232
PUM1 pumilio RNA-binding family member 1 0.0209031
CPNE8 copine VIII 0.0207944
SGMS2 sphingomyelin synthase 2 0.0206865
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0202691
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0201298
DENND4A DENN/MADD domain containing 4A 0.0199134
RAD23B RAD23 homolog B (S. cerevisiae) 0.0199124

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.30576
PTMA prothymosin, alpha -0.189114
ACTG1 actin gamma 1 -0.148517
TMSB10 thymosin beta 10 -0.117604
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0910777
TPT1 tumor protein, translationally-controlled 1 -0.0901285
RPL35A ribosomal protein L35a -0.0848917
FBXO32 F-box protein 32 -0.0799364
ISG15 ISG15 ubiquitin-like modifier -0.0795635
WSB1 WD repeat and SOCS box containing 1 -0.0725084
LAMB3 laminin, beta 3 -0.0719967
MT2A metallothionein 2A -0.070809
IFI27 interferon, alpha-inducible protein 27 -0.070781
LIMCH1 LIM and calponin homology domains 1 -0.069942
IFITM3 interferon induced transmembrane protein 3 -0.0677981
S100A6 S100 calcium binding protein A6 -0.0625744
IFI6 interferon, alpha-inducible protein 6 -0.0605018
CSTB cystatin B (stefin B) -0.0593307
HLA-B major histocompatibility complex, class I, B -0.0585783
RPS29 ribosomal protein S29 -0.0582518
BASP1 brain abundant, membrane attached signal protein 1 -0.0577475
TMSB4X thymosin beta 4, X-linked -0.0574652
RPLP1 ribosomal protein, large, P1 -0.0558075
RPLP2 ribosomal protein, large, P2 -0.0555241
SOX4 SRY (sex determining region Y)-box 4 -0.0552334
RPS8 ribosomal protein S8 -0.0545075
EIF1 eukaryotic translation initiation factor 1 -0.0544525
TPM4 tropomyosin 4 -0.0543595
LPP LIM domain containing preferred translocation partner in lipoma -0.0524556
RPS19 ribosomal protein S19 -0.0524325
RPS3 ribosomal protein S3 -0.0520398
HLA-A major histocompatibility complex, class I, A -0.049521
IFITM1 interferon induced transmembrane protein 1 -0.0487206
RPL34 ribosomal protein L34 -0.0478383
EXT1 exostosin glycosyltransferase 1 -0.0438206
VIM vimentin -0.0427308
GNAS GNAS complex locus -0.0420731
RPL37A ribosomal protein L37a -0.0419973
RPS27 ribosomal protein S27 -0.0416015
RPL8 ribosomal protein L8 -0.0410318
RPS12 ribosomal protein S12 -0.0404068
IFI16 interferon, gamma-inducible protein 16 -0.0391207
RAB7A RAB7A, member RAS oncogene family -0.0390245
CAVIN1 caveolae associated protein 1 -0.0387798
SAMD4A sterile alpha motif domain containing 4A -0.0386403
S100A9 S100 calcium binding protein A9 -0.038484
S100A10 S100 calcium binding protein A10 -0.037924
RPS6 ribosomal protein S6 -0.0375327
RPL31 ribosomal protein L31 -0.0371335
MYO1E myosin IE -0.0362609
RPL9 ribosomal protein L9 -0.0358448
RPS13 ribosomal protein S13 -0.0357441
IGFBP3 insulin-like growth factor binding protein 3 -0.0356404
RPL19 ribosomal protein L19 -0.0338447
KDM5B lysine (K)-specific demethylase 5B -0.0338194
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0337863
YY1 YY1 transcription factor -0.0337026
RAI14 retinoic acid induced 14 -0.0333209
RPL23 ribosomal protein L23 -0.0331814
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0329481
RPL36 ribosomal protein L36 -0.0324539
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0323102
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0313832
C15ORF48 chromosome 15 open reading frame 48 -0.0313201
RNF213 ring finger protein 213 -0.0311823
RRBP1 ribosome binding protein 1 -0.0311565
RPS17 ribosomal protein S17 -0.0310014
SLC38A1 solute carrier family 38, member 1 -0.0308979
PKM pyruvate kinase, muscle -0.0304581
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303725
CD63 CD63 molecule -0.0303385
TPI1 triosephosphate isomerase 1 -0.0301975
LMNA lamin A/C -0.030086
RPL37 ribosomal protein L37 -0.0300597
RPS27A ribosomal protein S27a -0.0300571
RPS25 ribosomal protein S25 -0.0297666
SH3KBP1 SH3-domain kinase binding protein 1 -0.0297228
F3 coagulation factor III (thromboplastin, tissue factor) -0.0295407
RPL12 ribosomal protein L12 -0.0294727
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0286092
RPL7A ribosomal protein L7a -0.028473
BLZF1 basic leucine zipper nuclear factor 1 -0.0281557
FBXO11 F-box protein 11 -0.0280821
HLA-E major histocompatibility complex, class I, E -0.0276113
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0274633
SQSTM1 sequestosome 1 -0.0271585
RPS14 ribosomal protein S14 -0.0269609
SRP54 signal recognition particle 54kDa -0.026721
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.026374
RPL36A ribosomal protein L36a -0.026172
ACBD3 acyl-CoA binding domain containing 3 -0.0257671
KLHL24 kelch-like family member 24 -0.0254246
CEP350 centrosomal protein 350kDa -0.0252437
ENO2 enolase 2 (gamma, neuronal) -0.025103
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0250959
FBXO34 F-box protein 34 -0.0247625
WASF2 WAS protein family, member 2 -0.0247272
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0244984
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0243561
S100A11 S100 calcium binding protein A11 -0.0243543