Silodosin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.0643124
NALF1 NALCN channel auxiliary factor 1 0.0614954
FNDC3B fibronectin type III domain containing 3B 0.0605175
ASPH aspartate beta-hydroxylase 0.0548188
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.054241
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0535392
NAMPT nicotinamide phosphoribosyltransferase 0.0485849
PDE4D phosphodiesterase 4D, cAMP-specific 0.0475785
PCBP2 poly(rC) binding protein 2 0.0431561
NRCAM neuronal cell adhesion molecule 0.0363899
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0359892
NUP58 nucleoporin 58 0.0345022
KDM6A lysine (K)-specific demethylase 6A 0.0326715
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0316616
LSAMP limbic system-associated membrane protein 0.0310292
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0303427
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0296448
KMT2E lysine (K)-specific methyltransferase 2E 0.0293452
AGFG1 ArfGAP with FG repeats 1 0.0293243
KMT2C lysine (K)-specific methyltransferase 2C 0.0288279
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0284466
DPY19L1 dpy-19-like 1 (C. elegans) 0.0284103
ESYT2 extended synaptotagmin-like protein 2 0.0282612
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0270946
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0269618
ECPAS Ecm29 proteasome adaptor and scaffold 0.0263689
USP9X ubiquitin specific peptidase 9, X-linked 0.0257997
UBA6 ubiquitin-like modifier activating enzyme 6 0.0251903
MSN moesin 0.0249582
CDH13 cadherin 13 0.0245974
TPM3 tropomyosin 3 0.0243723
NCKAP1 NCK-associated protein 1 0.0237165
AHR aryl hydrocarbon receptor 0.0230167
RNF145 ring finger protein 145 0.0227094
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0226701
GPRIN3 GPRIN family member 3 0.022482
SPAG9 sperm associated antigen 9 0.0221699
HELZ helicase with zinc finger 0.0220223
RBM39 RNA binding motif protein 39 0.0219818
SFPQ splicing factor proline/glutamine-rich 0.0218583
PUM2 pumilio RNA-binding family member 2 0.0215473
TENT5A terminal nucleotidyltransferase 5A 0.0212831
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0209886
CHD1 chromodomain helicase DNA binding protein 1 0.0205997
SUCO SUN domain containing ossification factor 0.0204776
RTN4 reticulon 4 0.020252
SP3 Sp3 transcription factor 0.019716
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0193634
MATR3 matrin 3 0.0191892
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0190352
TNIP1 TNFAIP3 interacting protein 1 0.0189022
ECT2 epithelial cell transforming 2 0.0185929
TXNRD1 thioredoxin reductase 1 0.0185458
FAM13A family with sequence similarity 13, member A 0.018086
UGCG UDP-glucose ceramide glucosyltransferase 0.0179656
EIF4B eukaryotic translation initiation factor 4B 0.0178287
SOD2 superoxide dismutase 2, mitochondrial 0.0176379
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0175146
TTC28 tetratricopeptide repeat domain 28 0.0174353
BCLAF1 BCL2-associated transcription factor 1 0.0173692
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.0172822
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0171667
AHCTF1 AT hook containing transcription factor 1 0.0168026
CPNE8 copine VIII 0.0167179
POTEF POTE ankyrin domain family, member F 0.0167163
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0167097
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0166505
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0166039
PSD3 pleckstrin and Sec7 domain containing 3 0.0164243
USP3 ubiquitin specific peptidase 3 0.0163563
TRA2A transformer 2 alpha homolog (Drosophila) 0.0162197
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0162155
RAD23B RAD23 homolog B (S. cerevisiae) 0.0160025
EZR ezrin 0.0158664
ZNF292 zinc finger protein 292 0.0158473
ATP13A3 ATPase type 13A3 0.0157985
CDC73 cell division cycle 73 0.0157756
ADAM9 ADAM metallopeptidase domain 9 0.0157417
XPO1 exportin 1 0.0157219
CD46 CD46 molecule, complement regulatory protein 0.0157147
OLA1 Obg-like ATPase 1 0.015629
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0155985
TFG TRK-fused gene 0.0154102
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0153685
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0152488
KCTD3 potassium channel tetramerization domain containing 3 0.0152168
VMP1 vacuole membrane protein 1 0.015152
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0151369
GRB10 growth factor receptor-bound protein 10 0.015046
UNC5D unc-5 homolog D (C. elegans) 0.0150389
CAMTA1 calmodulin binding transcription activator 1 0.0148364
EFNA5 ephrin-A5 0.0147653
OASL 2'-5'-oligoadenylate synthetase-like 0.01472
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.014611
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0145185
CHD1L chromodomain helicase DNA binding protein 1-like 0.0144764
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0142597
WAC WW domain containing adaptor with coiled-coil 0.0141477
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0140608
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0138994

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.263953
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.197556
VIM vimentin -0.139111
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.131848
TMSB10 thymosin beta 10 -0.128411
FTL ferritin, light polypeptide -0.103757
KYNU kynureninase -0.0913685
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0857013
RPL12 ribosomal protein L12 -0.0806569
TFPI2 tissue factor pathway inhibitor 2 -0.074191
MT2A metallothionein 2A -0.0739793
GDA guanine deaminase -0.0723514
RPS6 ribosomal protein S6 -0.0721971
PDE10A phosphodiesterase 10A -0.0710103
RPL37A ribosomal protein L37a -0.06593
RPLP1 ribosomal protein, large, P1 -0.0656742
RPL35A ribosomal protein L35a -0.0651037
IGFBP3 insulin-like growth factor binding protein 3 -0.0648082
TPT1 tumor protein, translationally-controlled 1 -0.0621293
TM4SF1 transmembrane 4 L six family member 1 -0.060848
NPAS2 neuronal PAS domain protein 2 -0.0600684
PTMA prothymosin, alpha -0.0595319
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0591025
RPL31 ribosomal protein L31 -0.0577991
RPS19 ribosomal protein S19 -0.0575913
RPL23 ribosomal protein L23 -0.0569441
RPS12 ribosomal protein S12 -0.0554062
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0552678
RPS8 ribosomal protein S8 -0.0547861
RPS3 ribosomal protein S3 -0.0547596
SAMD4A sterile alpha motif domain containing 4A -0.051401
FN1 fibronectin 1 -0.0512816
S100A6 S100 calcium binding protein A6 -0.0507913
RPL19 ribosomal protein L19 -0.0497428
RPS24 ribosomal protein S24 -0.0447605
RPL7A ribosomal protein L7a -0.0440841
BASP1 brain abundant, membrane attached signal protein 1 -0.0435333
VCL vinculin -0.0430297
RPL36 ribosomal protein L36 -0.0421894
RPL26 ribosomal protein L26 -0.0412213
RPL36A ribosomal protein L36a -0.0406083
EIF1 eukaryotic translation initiation factor 1 -0.0397741
GNAS GNAS complex locus -0.0395996
TGFBI transforming growth factor, beta-induced, 68kDa -0.0393822
RPL9 ribosomal protein L9 -0.0393789
RPS27 ribosomal protein S27 -0.0378572
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0373997
RPS27A ribosomal protein S27a -0.0369878
NCOA7 nuclear receptor coactivator 7 -0.0369334
RPL34 ribosomal protein L34 -0.0355694
ELL2 elongation factor, RNA polymerase II, 2 -0.0354798
ACTG1 actin gamma 1 -0.0351083
RPL35 ribosomal protein L35 -0.0350583
RPLP2 ribosomal protein, large, P2 -0.0350038
RPL13A ribosomal protein L13a -0.0347897
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0345854
RPLP0 ribosomal protein, large, P0 -0.0345429
RPS29 ribosomal protein S29 -0.0342832
RPL11 ribosomal protein L11 -0.0340159
RPS14 ribosomal protein S14 -0.0332997
COL4A5 collagen, type IV, alpha 5 -0.0329349
OSMR oncostatin M receptor -0.0327794
RPS16 ribosomal protein S16 -0.0323458
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0316779
RPL37 ribosomal protein L37 -0.0315305
RPS25 ribosomal protein S25 -0.0314032
SLC38A2 solute carrier family 38, member 2 -0.031072
EEF2 eukaryotic translation elongation factor 2 -0.031038
RACK1 receptor for activated C kinase 1 -0.0303435
NDRG1 N-myc downstream regulated 1 -0.0301178
ADGRD1 adhesion G protein-coupled receptor D1 -0.0297486
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0297134
SRGN serglycin -0.0291074
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0286544
FNDC3A fibronectin type III domain containing 3A -0.0286527
SH3KBP1 SH3-domain kinase binding protein 1 -0.0286484
WSB1 WD repeat and SOCS box containing 1 -0.0284054
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0283782
TBCA tubulin folding cofactor A -0.0282593
BPTF bromodomain PHD finger transcription factor -0.0280053
STC1 stanniocalcin 1 -0.0278693
B2M beta-2-microglobulin -0.0278311
RPL5 ribosomal protein L5 -0.0277794
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0277357
SMAD2 SMAD family member 2 -0.0276767
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.027544
NAP1L1 nucleosome assembly protein 1-like 1 -0.0272529
RPL32 ribosomal protein L32 -0.0271711
RPS13 ribosomal protein S13 -0.0270551
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0267577
ANTXR1 anthrax toxin receptor 1 -0.0263233
PHF20 PHD finger protein 20 -0.0257399
YBX3 Y box binding protein 3 -0.0256812
RPL10A ribosomal protein L10a -0.0254753
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0253064
IGF1R insulin-like growth factor 1 receptor -0.0252064
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.025138
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0251267
NTN4 netrin 4 -0.025108
ATP5F1E ATP synthase F1 subunit epsilon -0.0249458