Silodosin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

180 genes differentially expressed following the Silodosin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.301688
EGFR epidermal growth factor receptor 0.194876
TBC1D22A TBC1 domain family, member 22A 0.157501
USP9X ubiquitin specific peptidase 9, X-linked 0.146567
KANSL1 KAT8 regulatory NSL complex subunit 1 0.13662
USP34 ubiquitin specific peptidase 34 0.124485
ANXA2 annexin A2 0.114367
LMO7 LIM domain 7 0.11403
SAMD12 sterile alpha motif domain containing 12 0.112028
ASPH aspartate beta-hydroxylase 0.107085
SPAG9 sperm associated antigen 9 0.0965912
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.09408
UBA6 ubiquitin-like modifier activating enzyme 6 0.0902029
BIRC6 baculoviral IAP repeat containing 6 0.0884987
DOCK5 dedicator of cytokinesis 5 0.0863347
GOLGB1 golgin B1 0.0858811
DSCAM Down syndrome cell adhesion molecule 0.083736
RPS3 ribosomal protein S3 0.0808141
EIF1 eukaryotic translation initiation factor 1 0.0768109
ZNF292 zinc finger protein 292 0.0766835
GPHN gephyrin 0.0766485
MYH9 myosin, heavy chain 9, non-muscle 0.0766417
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0751884
NIPBL Nipped-B homolog (Drosophila) 0.07036
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0675279
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0670728
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0670619
MATR3 matrin 3 0.0623233
NDRG1 N-myc downstream regulated 1 0.0613252
ZBTB20 zinc finger and BTB domain containing 20 0.0611321
FTH1 ferritin, heavy polypeptide 1 0.0563847
TTC3 tetratricopeptide repeat domain 3 0.0503264
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0477769
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0473251
TRIO trio Rho guanine nucleotide exchange factor 0.0458764
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0423175
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0415854
RBM39 RNA binding motif protein 39 0.0389788
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0386881
PGK1 phosphoglycerate kinase 1 0.0371
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0368667
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0365828
GOLGA4 golgin A4 0.0349084
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0348807
PDE10A phosphodiesterase 10A 0.0332936
PRRC2C proline-rich coiled-coil 2C 0.0325406
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0316266
GRB10 growth factor receptor-bound protein 10 0.0303964
TXNRD1 thioredoxin reductase 1 0.0285514
RPL37A ribosomal protein L37a 0.0273625
BACE2 beta-site APP-cleaving enzyme 2 0.0271489
UBE2H ubiquitin-conjugating enzyme E2H 0.0268109
ESYT2 extended synaptotagmin-like protein 2 0.0215931
RPL9 ribosomal protein L9 0.0163557
ENO1 enolase 1, (alpha) 0.0154916
RAB10 RAB10, member RAS oncogene family 0.0152811
SH3KBP1 SH3-domain kinase binding protein 1 0.0151731
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0108423
KTN1 kinectin 1 (kinesin receptor) 0.00993352
NKD1 naked cuticle homolog 1 (Drosophila) 0.0096929
AHNAK AHNAK nucleoprotein 0.00967055
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0095507
CSDE1 cold shock domain containing E1, RNA-binding 0.00925732
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00871885
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0082059
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00812824
MYOF myoferlin 0.00737632
MYO10 myosin X 0.00702533
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00636982
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.00542837
ZSWIM6 zinc finger, SWIM-type containing 6 0.00414884
RPS6 ribosomal protein S6 0.00402393
TMSB4X thymosin beta 4, X-linked 0.00367173
WSB1 WD repeat and SOCS box containing 1 0.00335803
LAMA4 laminin, alpha 4 0.00298142
WDFY3 WD repeat and FYVE domain containing 3 0.0028308
TMEM165 transmembrane protein 165 0.00243479
SAMD4A sterile alpha motif domain containing 4A 0.00166251
LOC112694756 uncharaterized LOC112694756 7.24543E-4
GLG1 golgi glycoprotein 1 6.2528E-4

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.22088
GPC6 glypican 6 -0.124215
FNDC3B fibronectin type III domain containing 3B -0.108828
AKAP12 A kinase (PRKA) anchor protein 12 -0.107749
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107232
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0936968
CDH13 cadherin 13 -0.0920442
EXT1 exostosin glycosyltransferase 1 -0.0900389
DST dystonin -0.0822956
ACTG1 actin gamma 1 -0.0809894
TMSB10 thymosin beta 10 -0.0736166
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0731829
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0715305
EEF2 eukaryotic translation elongation factor 2 -0.0686132
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0664924
MRPS6 mitochondrial ribosomal protein S6 -0.0653006
OSMR oncostatin M receptor -0.0652416
SMYD3 SET and MYND domain containing 3 -0.0643938
ZFAND3 zinc finger, AN1-type domain 3 -0.0636455
FN1 fibronectin 1 -0.0636451
DLG1 discs, large homolog 1 (Drosophila) -0.0632337
SPIDR scaffolding protein involved in DNA repair -0.0612347
INHBA inhibin, beta A -0.0610211
NAP1L1 nucleosome assembly protein 1-like 1 -0.0603029
HMGA2 high mobility group AT-hook 2 -0.0571907
RPL35A ribosomal protein L35a -0.056695
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.056385
KMT2C lysine (K)-specific methyltransferase 2C -0.0563684
IGFBP3 insulin-like growth factor binding protein 3 -0.0555885
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0551481
SBF2 SET binding factor 2 -0.0539287
JMJD1C jumonji domain containing 1C -0.0530036
CANX calnexin -0.051661
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0513856
PDIA6 protein disulfide isomerase family A, member 6 -0.0509104
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0499473
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0494664
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0485519
PDE4D phosphodiesterase 4D, cAMP-specific -0.0482256
COG5 component of oligomeric golgi complex 5 -0.0467029
PTK2 protein tyrosine kinase 2 -0.0466979
PSD3 pleckstrin and Sec7 domain containing 3 -0.0466466
CEP170 centrosomal protein 170kDa -0.0460071
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.041062
HELZ helicase with zinc finger -0.0405229
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0396344
VMP1 vacuole membrane protein 1 -0.0395799
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0389413
CD44 CD44 molecule (Indian blood group) -0.0378224
RPL5 ribosomal protein L5 -0.0375205
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0369939
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0352225
FMNL2 formin-like 2 -0.0346218
FMN1 formin 1 -0.034302
RPS8 ribosomal protein S8 -0.0342098
COL6A1 collagen, type VI, alpha 1 -0.0338139
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0336855
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.033529
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0326606
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0319465
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0318433
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0313251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0312434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0297121
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0293712
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0285596
ZMYND8 zinc finger, MYND-type containing 8 -0.0284567
OXSR1 oxidative stress responsive 1 -0.0281896
COL6A3 collagen, type VI, alpha 3 -0.0281461
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0280244
EFNA5 ephrin-A5 -0.0279095
GNAS GNAS complex locus -0.0277645
NOP58 NOP58 ribonucleoprotein -0.0276089
ZNF609 zinc finger protein 609 -0.0273653
CDK12 cyclin-dependent kinase 12 -0.0264869
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0260786
NALF1 NALCN channel auxiliary factor 1 -0.0256309
RPL31 ribosomal protein L31 -0.0245334
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0242207
PKM pyruvate kinase, muscle -0.0233936
DOCK4 dedicator of cytokinesis 4 -0.022939
OGA O-GlcNAcase -0.0214253
FLNB filamin B, beta -0.0212557
ANTXR2 anthrax toxin receptor 2 -0.0202066
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0196272
RPL7 ribosomal protein L7 -0.0186266
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0182443
GIGYF2 GRB10 interacting GYF protein 2 -0.0182409
DSTN destrin (actin depolymerizing factor) -0.0181201
RARS1 arginyl-tRNA synthetase 1 -0.0175394
CUX1 cut-like homeobox 1 -0.0157399
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0153292
ELL2 elongation factor, RNA polymerase II, 2 -0.0153047
TGFBI transforming growth factor, beta-induced, 68kDa -0.0141202
PTMA prothymosin, alpha -0.0139426
MACF1 microtubule-actin crosslinking factor 1 -0.0135853
RPL23 ribosomal protein L23 -0.0134314
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0131059
SETD5 SET domain containing 5 -0.0129999
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0128306