Silodosin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0669124
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0582139
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0390407
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0384297
MEF2A myocyte enhancer factor 2A 0.0342918
MEMO1 mediator of cell motility 1 0.0338973
MKI67 marker of proliferation Ki-67 0.0333547
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300784
ASCC3 activating signal cointegrator 1 complex subunit 3 0.028866
PDGFC platelet derived growth factor C 0.028738
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0285792
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0284362
ZNF608 zinc finger protein 608 0.0275938
ZFAND3 zinc finger, AN1-type domain 3 0.0269624
UBQLN1 ubiquilin 1 0.0263544
EIF4B eukaryotic translation initiation factor 4B 0.0258923
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0258663
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0258512
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0257451
YAP1 Yes-associated protein 1 0.0255144
FXR1 fragile X mental retardation, autosomal homolog 1 0.0251159
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0245722
EIF4A2 eukaryotic translation initiation factor 4A2 0.0244714
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.024432
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241977
PSME4 proteasome (prosome, macropain) activator subunit 4 0.024087
RPS2 ribosomal protein S2 0.0240567
FUBP1 far upstream element (FUSE) binding protein 1 0.0240315
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0238166
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0233004
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0225161
OLA1 Obg-like ATPase 1 0.022443
QKI QKI, KH domain containing, RNA binding 0.0222792
SEC63 SEC63 homolog (S. cerevisiae) 0.0221286
DPYD dihydropyrimidine dehydrogenase 0.0217745
BZW1 basic leucine zipper and W2 domains 1 0.0217475
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.0217439
GASK1B golgi associated kinase 1B 0.0215304
SP3 Sp3 transcription factor 0.0213556
AQR aquarius intron-binding spliceosomal factor 0.0213098
YME1L1 YME1-like 1 ATPase 0.0207267
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0207196
MB21D2 Mab-21 domain containing 2 0.0203551
SENP5 SUMO1/sentrin specific peptidase 5 0.019883
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0196754
SKP1 S-phase kinase-associated protein 1 0.0196544
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0196118
CRY1 cryptochrome circadian clock 1 0.0195546
UTRN utrophin 0.0193451
NONO non-POU domain containing, octamer-binding 0.0190455
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0187453
ZNF292 zinc finger protein 292 0.0185927
RAD23B RAD23 homolog B (S. cerevisiae) 0.0182461
RAD21 RAD21 homolog (S. pombe) 0.0180802
PGAP1 post-GPI attachment to proteins 1 0.018062
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0180527
RPL13A ribosomal protein L13a 0.0180504
COL5A2 collagen, type V, alpha 2 0.0179431
AHCTF1 AT hook containing transcription factor 1 0.0177497
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0176373
CAMKMT calmodulin-lysine N-methyltransferase 0.017549
RIMS2 regulating synaptic membrane exocytosis 2 0.0175312
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0175024
LSAMP limbic system-associated membrane protein 0.0174694
SET SET nuclear proto-oncogene 0.0174287
RBM26 RNA binding motif protein 26 0.017381
CYRIB CYFIP related Rac1 interactor B 0.0173052
CCNA2 cyclin A2 0.0172881
SSB Sjogren syndrome antigen B (autoantigen La) 0.0172179
ZEB2 zinc finger E-box binding homeobox 2 0.0171978
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0171649
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0171272
UBA6 ubiquitin-like modifier activating enzyme 6 0.0171049
NAMPT nicotinamide phosphoribosyltransferase 0.0169715
GLS2 glutaminase 2 (liver, mitochondrial) 0.0169632
SKA2 spindle and kinetochore associated complex subunit 2 0.0169357
NIPBL Nipped-B homolog (Drosophila) 0.0169215
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0166678
ADGRG6 adhesion G protein-coupled receptor G6 0.0166627
MARCHF6 membrane associated ring-CH-type finger 6 0.0166105
SH3RF2 SH3 domain containing ring finger 2 0.0166061
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.016562
N4BP2 NEDD4 binding protein 2 0.0165229
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0164305
ZNF451 zinc finger protein 451 0.0163405
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0163208
SRSF1 serine/arginine-rich splicing factor 1 0.0163206
NFE2L1 nuclear factor, erythroid 2-like 1 0.0162801
TMEM39A transmembrane protein 39A 0.0162191
USP22 ubiquitin specific peptidase 22 0.016202
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0161609
LARP1 La ribonucleoprotein domain family, member 1 0.016077
STK38L serine/threonine kinase 38 like 0.0159949
PRTG protogenin 0.0159135
VAMP7 vesicle-associated membrane protein 7 0.0158313
SPAG9 sperm associated antigen 9 0.0158158
LAMP2 lysosomal-associated membrane protein 2 0.0157444
ANKRD50 ankyrin repeat domain 50 0.0155925
OSBPL9 oxysterol binding protein-like 9 0.0155683
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.015349

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.286256
COL11A1 collagen, type XI, alpha 1 -0.147796
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108816
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.105825
RPS6 ribosomal protein S6 -0.0920175
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0760723
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0757533
PCDH9 protocadherin 9 -0.0731271
TMSB10 thymosin beta 10 -0.0717081
MED13L mediator complex subunit 13-like -0.0698055
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0682265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0649429
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0609113
ENO1 enolase 1, (alpha) -0.0571401
ADGRL2 adhesion G protein-coupled receptor L2 -0.056253
ATP5F1B ATP synthase F1 subunit beta -0.0558959
ITGAV integrin, alpha V -0.0514988
GPC3 glypican 3 -0.0514057
RPL23 ribosomal protein L23 -0.0504229
RPL35A ribosomal protein L35a -0.0501501
MDK midkine (neurite growth-promoting factor 2) -0.0494667
GNAS GNAS complex locus -0.0492491
RPS16 ribosomal protein S16 -0.0491024
WSB1 WD repeat and SOCS box containing 1 -0.0488369
ADGRV1 adhesion G protein-coupled receptor V1 -0.0484019
ACTG1 actin gamma 1 -0.0479248
CADM2 cell adhesion molecule 2 -0.047118
PGK1 phosphoglycerate kinase 1 -0.0465933
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0463205
FTL ferritin, light polypeptide -0.0453892
RPS8 ribosomal protein S8 -0.044788
RAD51B RAD51 paralog B -0.0443213
PDIA3 protein disulfide isomerase family A, member 3 -0.0432652
PEG10 paternally expressed 10 -0.0428577
PCLO piccolo presynaptic cytomatrix protein -0.0424439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0411468
RERE arginine-glutamic acid dipeptide (RE) repeats -0.041012
PARD3B par-3 family cell polarity regulator beta -0.0409002
BPTF bromodomain PHD finger transcription factor -0.0386815
TPT1 tumor protein, translationally-controlled 1 -0.038493
TRIO trio Rho guanine nucleotide exchange factor -0.0379324
SCAF11 SR-related CTD-associated factor 11 -0.0376545
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0367784
SLC38A2 solute carrier family 38, member 2 -0.0366593
RPS27A ribosomal protein S27a -0.036554
PDIA6 protein disulfide isomerase family A, member 6 -0.0359823
ANKRD33B ankyrin repeat domain 33B -0.0355453
PFN1 profilin 1 -0.0353075
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0351012
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0349509
RPS19 ribosomal protein S19 -0.0338289
SETD5 SET domain containing 5 -0.0334635
WASF2 WAS protein family, member 2 -0.0331494
USP34 ubiquitin specific peptidase 34 -0.0328479
SNX6 sorting nexin 6 -0.0326942
EMP1 epithelial membrane protein 1 -0.0323676
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0320267
MRPS6 mitochondrial ribosomal protein S6 -0.0319781
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0308963
RPL30 ribosomal protein L30 -0.0308171
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0306093
ANXA2 annexin A2 -0.0300683
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0298734
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0296623
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0295825
TXNRD1 thioredoxin reductase 1 -0.0295727
PHIP pleckstrin homology domain interacting protein -0.0295458
B2M beta-2-microglobulin -0.0295092
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0291476
SPTSSA serine palmitoyltransferase, small subunit A -0.0288836
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0287077
TSC22D2 TSC22 domain family, member 2 -0.0286163
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0283993
STRN3 striatin, calmodulin binding protein 3 -0.0283147
GOLGA4 golgin A4 -0.0283073
ZBTB20 zinc finger and BTB domain containing 20 -0.0282267
TPD52 tumor protein D52 -0.0281792
ISG15 ISG15 ubiquitin-like modifier -0.0280141
NCAM2 neural cell adhesion molecule 2 -0.02798
OGA O-GlcNAcase -0.0276137
MT2A metallothionein 2A -0.0273589
ENAH enabled homolog (Drosophila) -0.0271534
FAM177A1 family with sequence similarity 177, member A1 -0.027153
FN1 fibronectin 1 -0.0270744
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0270511
WNK1 WNK lysine deficient protein kinase 1 -0.0269468
HMGB1 high mobility group box 1 -0.0262485
KTN1 kinectin 1 (kinesin receptor) -0.026235
SAMD4B sterile alpha motif domain containing 4B -0.0261386
PRELID2 PRELI domain containing 2 -0.0260886
KMT2A lysine (K)-specific methyltransferase 2A -0.0260237
DEK DEK proto-oncogene -0.0257237
MEIS2 Meis homeobox 2 -0.0256259
FST follistatin -0.0256152
KIF13A kinesin family member 13A -0.0256004
SYT1 synaptotagmin I -0.025217
YY1 YY1 transcription factor -0.0249543
DST dystonin -0.0247535
HMCN1 hemicentin 1 -0.0245794
FBXO17 F-box protein 17 -0.024389