Silodosin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Silodosin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100912
GOLGA4 golgin A4 0.0882279
TXNIP thioredoxin interacting protein 0.0799471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0757501
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0741317
VMP1 vacuole membrane protein 1 0.0726897
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0702454
PCBP2 poly(rC) binding protein 2 0.0693042
LOC112694756 uncharaterized LOC112694756 0.0692863
NUP58 nucleoporin 58 0.0669634
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0667464
CD47 CD47 molecule 0.066697
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.062686
LDHA lactate dehydrogenase A 0.0611703
RBM39 RNA binding motif protein 39 0.0599955
SMC3 structural maintenance of chromosomes 3 0.0569785
FLNB filamin B, beta 0.0559288
RHOA ras homolog family member A 0.0530994
PTBP2 polypyrimidine tract binding protein 2 0.0512745
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0511976
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0508343
BIRC6 baculoviral IAP repeat containing 6 0.050732
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0505403
TMEM41B transmembrane protein 41B 0.0504658
EIF4B eukaryotic translation initiation factor 4B 0.0484294
ELOVL5 ELOVL fatty acid elongase 5 0.0483727
NF1 neurofibromin 1 0.0477671
ADAM10 ADAM metallopeptidase domain 10 0.0474115
RNF145 ring finger protein 145 0.0472673
WDR43 WD repeat domain 43 0.0467
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0466181
COG5 component of oligomeric golgi complex 5 0.0465223
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0462701
COPA coatomer protein complex, subunit alpha 0.0448862
PICALM phosphatidylinositol binding clathrin assembly protein 0.0436766
RTN4 reticulon 4 0.0421289
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0420259
RNMT RNA (guanine-7-) methyltransferase 0.0419448
RBM25 RNA binding motif protein 25 0.0418759
ZNF292 zinc finger protein 292 0.0409107
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.040498
MATR3 matrin 3 0.0392826
HDLBP high density lipoprotein binding protein 0.0388272
RPLP0 ribosomal protein, large, P0 0.0382298
LMAN1 lectin, mannose-binding, 1 0.0381791
TGFBR3 transforming growth factor, beta receptor III 0.037192
DSTN destrin (actin depolymerizing factor) 0.0370078
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0365155
SMNDC1 survival motor neuron domain containing 1 0.0364697
NBAS neuroblastoma amplified sequence 0.0358173
USP3 ubiquitin specific peptidase 3 0.0357584
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0354521
POTEF POTE ankyrin domain family, member F 0.0352763
CALR calreticulin 0.0352604
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0351642
TFG TRK-fused gene 0.0347197
CSDE1 cold shock domain containing E1, RNA-binding 0.0342247
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.033949
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0337792
RHBDD1 rhomboid domain containing 1 0.0335589
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0332409
ANK2 ankyrin 2, neuronal 0.0330533
SRRM2 serine/arginine repetitive matrix 2 0.0320127
CHD1 chromodomain helicase DNA binding protein 1 0.0317095
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0316627
UBA6 ubiquitin-like modifier activating enzyme 6 0.0315626
KDM3A lysine (K)-specific demethylase 3A 0.0313825
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0311997
GOLGA2 golgin A2 0.0306578
FXR1 fragile X mental retardation, autosomal homolog 1 0.0302199
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0301991
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0301801
QKI QKI, KH domain containing, RNA binding 0.0301221
VIRMA vir like m6A methyltransferase associated 0.03011
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0300194
TRA2A transformer 2 alpha homolog (Drosophila) 0.0299086
RAB18 RAB18, member RAS oncogene family 0.0299086
YME1L1 YME1-like 1 ATPase 0.029813
PRRC1 proline-rich coiled-coil 1 0.0297768
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0296043
NFIA nuclear factor I/A 0.0295804
FNBP4 formin binding protein 4 0.0295053
ECPAS Ecm29 proteasome adaptor and scaffold 0.0294519
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0293347
PNISR PNN-interacting serine/arginine-rich protein 0.0292281
SLMAP sarcolemma associated protein 0.029198
PUM2 pumilio RNA-binding family member 2 0.0288614
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0287153
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0286706
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0281388
TNPO1 transportin 1 0.0279832
PYGB phosphorylase, glycogen; brain 0.027797
ENO1 enolase 1, (alpha) 0.0277858
ZFC3H1 zinc finger, C3H1-type containing 0.027771
PNN pinin, desmosome associated protein 0.0275197
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0270781
SBF2 SET binding factor 2 0.0266343
ADAM9 ADAM metallopeptidase domain 9 0.0265448
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0265134
PHF21A PHD finger protein 21A 0.0264505

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226424
PDE4D phosphodiesterase 4D, cAMP-specific -0.214835
BMP10 bone morphogenetic protein 10 -0.131429
PDE4B phosphodiesterase 4B, cAMP-specific -0.126084
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0978559
TPT1 tumor protein, translationally-controlled 1 -0.0842475
TM4SF1 transmembrane 4 L six family member 1 -0.0668124
PRELID2 PRELI domain containing 2 -0.0654225
CCND1 cyclin D1 -0.0649349
ANXA1 annexin A1 -0.0647234
MKI67 marker of proliferation Ki-67 -0.064246
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0535047
RPL31 ribosomal protein L31 -0.0534085
AHNAK AHNAK nucleoprotein -0.051546
PKM pyruvate kinase, muscle -0.0509789
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0499308
VCL vinculin -0.0481997
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0477174
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0467808
RPS8 ribosomal protein S8 -0.0458667
S100A4 S100 calcium binding protein A4 -0.0454065
MYOF myoferlin -0.0448757
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.044221
RPL9 ribosomal protein L9 -0.0435282
GSE1 Gse1 coiled-coil protein -0.043092
MACROD2 MACRO domain containing 2 -0.0409787
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0405694
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0402657
SMC4 structural maintenance of chromosomes 4 -0.0387862
IFI16 interferon, gamma-inducible protein 16 -0.0377646
SDK1 sidekick cell adhesion molecule 1 -0.0377219
INTS6 integrator complex subunit 6 -0.0374652
GLI2 GLI family zinc finger 2 -0.0373733
GLI3 GLI family zinc finger 3 -0.0373255
BMP2K BMP2 inducible kinase -0.037071
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0368574
MYO5C myosin VC -0.0356587
ACTG1 actin gamma 1 -0.0355471
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0351411
SLC38A2 solute carrier family 38, member 2 -0.0340857
RPL8 ribosomal protein L8 -0.0337709
EGFR epidermal growth factor receptor -0.0333846
RPS13 ribosomal protein S13 -0.0331672
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0329867
RPL34 ribosomal protein L34 -0.0324108
S100A10 S100 calcium binding protein A10 -0.032324
DIAPH3 diaphanous-related formin 3 -0.0322454
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.032029
ANLN anillin, actin binding protein -0.0319736
CREB5 cAMP responsive element binding protein 5 -0.0319164
FUS FUS RNA binding protein -0.0318814
RPL38 ribosomal protein L38 -0.0317388
UBC ubiquitin C -0.0313881
RFC3 replication factor C (activator 1) 3, 38kDa -0.0306197
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.030401
FOXP1 forkhead box P1 -0.030055
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0297995
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.02952
LOC102724023 ES1 protein homolog, mitochondrial -0.0293315
KIAA1958 KIAA1958 -0.0288448
H1-4 H1.4 linker histone, cluster member -0.0288326
SCLT1 sodium channel and clathrin linker 1 -0.0287437
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0282595
HJURP Holliday junction recognition protein -0.0281644
RPLP1 ribosomal protein, large, P1 -0.0278916
ARL4C ADP-ribosylation factor-like 4C -0.0273027
ZNF608 zinc finger protein 608 -0.0272998
UNC13A unc-13 homolog A (C. elegans) -0.0269441
S100A11 S100 calcium binding protein A11 -0.0269235
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0266367
NAV2 neuron navigator 2 -0.0265197
SQSTM1 sequestosome 1 -0.0257679
RPL36 ribosomal protein L36 -0.0257639
RRM2 ribonucleotide reductase M2 -0.0257431
HSPA8 heat shock 70kDa protein 8 -0.0254677
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0251518
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -0.0250317
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0245612
ZMYND8 zinc finger, MYND-type containing 8 -0.0245155
TMSB4X thymosin beta 4, X-linked -0.0243081
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0240794
IRS1 insulin receptor substrate 1 -0.0236958
FER1L6 fer-1-like family member 6 -0.023457
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0228925
AEBP2 AE binding protein 2 -0.0228706
RPL5 ribosomal protein L5 -0.0228377
CDK13 cyclin-dependent kinase 13 -0.0227795
RPS10 ribosomal protein S10 -0.0226866
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0225857
PKP4 plakophilin 4 -0.0225044
FTL ferritin, light polypeptide -0.022473
RPLP2 ribosomal protein, large, P2 -0.0223364
CUX1 cut-like homeobox 1 -0.0219711
SP100 SP100 nuclear antigen -0.0219676
NCEH1 neutral cholesterol ester hydrolase 1 -0.021879
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.0215512
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0215104
RPL35A ribosomal protein L35a -0.02128
TAOK1 TAO kinase 1 -0.0212128
GPATCH8 G patch domain containing 8 -0.0208543