Silodosin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.13998
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0864824
FN1 fibronectin 1 0.0845334
MYH9 myosin, heavy chain 9, non-muscle 0.0650835
FRMD4A FERM domain containing 4A 0.0593705
COL6A3 collagen, type VI, alpha 3 0.0518669
NAMPT nicotinamide phosphoribosyltransferase 0.0459659
FNDC3B fibronectin type III domain containing 3B 0.0449557
DST dystonin 0.0367427
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0363988
VCAN versican 0.0358821
USP9X ubiquitin specific peptidase 9, X-linked 0.0346666
SMAD3 SMAD family member 3 0.0307397
ELL2 elongation factor, RNA polymerase II, 2 0.0292483
VMP1 vacuole membrane protein 1 0.0279387
BICC1 BicC family RNA binding protein 1 0.0277801
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0261518
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0234465
EXT1 exostosin glycosyltransferase 1 0.0234254
PDE10A phosphodiesterase 10A 0.0229208
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0214068
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0213532
MSN moesin 0.021165
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0209144
UBA6 ubiquitin-like modifier activating enzyme 6 0.0202088
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0200344
ARRDC3 arrestin domain containing 3 0.0199575
AFDN afadin, adherens junction formation factor 0.0187846
CENPF centromere protein F, 350/400kDa 0.0187341
TENT5A terminal nucleotidyltransferase 5A 0.0186529
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0184424
ATP13A3 ATPase type 13A3 0.0180752
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.017672
THBS1 thrombospondin 1 0.0174283
GLIS3 GLIS family zinc finger 3 0.0166649
NAV2 neuron navigator 2 0.0161811
ANLN anillin, actin binding protein 0.0161654
RTN4 reticulon 4 0.0153872
RIGI RNA sensor RIG-I 0.0152043
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0150205
TNIP1 TNFAIP3 interacting protein 1 0.0146819
SBF2 SET binding factor 2 0.0145076
AHR aryl hydrocarbon receptor 0.0143153
KYNU kynureninase 0.0143071
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0141082
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0140683
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0138575
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0138363
KLF12 Kruppel-like factor 12 0.0138336
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0137233
KDM6A lysine (K)-specific demethylase 6A 0.0137214
BCLAF1 BCL2-associated transcription factor 1 0.0136932
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136778
PTPRK protein tyrosine phosphatase, receptor type, K 0.0134696
TBC1D5 TBC1 domain family, member 5 0.0134482
CADM1 cell adhesion molecule 1 0.0133726
MX1 MX dynamin-like GTPase 1 0.0133143
RUNX2 runt-related transcription factor 2 0.013242
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0131656
HELZ helicase with zinc finger 0.0131186
CKAP5 cytoskeleton associated protein 5 0.0129907
ANO6 anoctamin 6 0.0128374
MYOF myoferlin 0.0126849
DENND5A DENN/MADD domain containing 5A 0.0126661
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.012615
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0123158
SPAG9 sperm associated antigen 9 0.0122163
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0120714
ANXA5 annexin A5 0.0120366
LAMP2 lysosomal-associated membrane protein 2 0.0119897
ZNF608 zinc finger protein 608 0.0118707
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0116999
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.011673
OGA O-GlcNAcase 0.0115604
RAD51B RAD51 paralog B 0.0115529
BLTP1 bridge-like lipid transfer protein family member 1 0.0115044
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0114425
USP47 ubiquitin specific peptidase 47 0.0113168
NUP153 nucleoporin 153kDa 0.0113053
ZBTB20 zinc finger and BTB domain containing 20 0.0112202
EIF4B eukaryotic translation initiation factor 4B 0.0112058
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0111705
PTBP3 polypyrimidine tract binding protein 3 0.01109
WDR26 WD repeat domain 26 0.0109127
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0109035
SCAF8 SR-related CTD-associated factor 8 0.0108603
BIRC3 baculoviral IAP repeat containing 3 0.0108005
XPO1 exportin 1 0.0107409
LPP LIM domain containing preferred translocation partner in lipoma 0.0107401
ZFC3H1 zinc finger, C3H1-type containing 0.0105974
TNS3 tensin 3 0.0105022
LRRC7 leucine rich repeat containing 7 0.0103476
CD46 CD46 molecule, complement regulatory protein 0.0102246
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.010134
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0100756
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0099942
PSD3 pleckstrin and Sec7 domain containing 3 0.00989505
CEP95 centrosomal protein 95kDa 0.00987908
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.00986243
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.00984643

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.377934
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232175
HLA-B major histocompatibility complex, class I, B -0.178258
FTL ferritin, light polypeptide -0.166528
TMSB10 thymosin beta 10 -0.141374
TPT1 tumor protein, translationally-controlled 1 -0.128432
MT2A metallothionein 2A -0.126421
IER3 immediate early response 3 -0.107923
RPS6 ribosomal protein S6 -0.104382
RPS8 ribosomal protein S8 -0.0891659
PTMA prothymosin, alpha -0.0847362
RPL23 ribosomal protein L23 -0.0828442
B2M beta-2-microglobulin -0.08087
RPLP2 ribosomal protein, large, P2 -0.080544
RPS12 ribosomal protein S12 -0.0802752
RPL35A ribosomal protein L35a -0.0781248
RPL37A ribosomal protein L37a -0.0763428
RPLP1 ribosomal protein, large, P1 -0.0688241
RPS3 ribosomal protein S3 -0.0666471
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0663807
HLA-A major histocompatibility complex, class I, A -0.0656808
NDRG1 N-myc downstream regulated 1 -0.0642539
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0641917
RPS24 ribosomal protein S24 -0.0607611
ADM adrenomedullin -0.0604609
RPL36A ribosomal protein L36a -0.0580141
RPS19 ribosomal protein S19 -0.0564126
RPS23 ribosomal protein S23 -0.0557349
EIF1 eukaryotic translation initiation factor 1 -0.0550238
RPL9 ribosomal protein L9 -0.0538762
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0533361
RPS13 ribosomal protein S13 -0.0531364
RPL19 ribosomal protein L19 -0.0526562
RPL12 ribosomal protein L12 -0.0517378
RPL11 ribosomal protein L11 -0.050382
RPL31 ribosomal protein L31 -0.0500787
AKAP12 A kinase (PRKA) anchor protein 12 -0.0498387
RPL36 ribosomal protein L36 -0.0484995
IFITM3 interferon induced transmembrane protein 3 -0.0478243
ACTG1 actin gamma 1 -0.0464092
RPL26 ribosomal protein L26 -0.0454711
RPS27A ribosomal protein S27a -0.0439655
RPS4X ribosomal protein S4, X-linked -0.0436369
RPL7A ribosomal protein L7a -0.0432804
NAP1L1 nucleosome assembly protein 1-like 1 -0.0425942
ENO1 enolase 1, (alpha) -0.0425124
RPL5 ribosomal protein L5 -0.0418954
RPS29 ribosomal protein S29 -0.0415253
RPS25 ribosomal protein S25 -0.0410711
RACK1 receptor for activated C kinase 1 -0.0401646
RPS10 ribosomal protein S10 -0.0401121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0392047
WSB1 WD repeat and SOCS box containing 1 -0.0391435
CALR calreticulin -0.0383713
RPL37 ribosomal protein L37 -0.0383227
IGFBP3 insulin-like growth factor binding protein 3 -0.0381902
RPLP0 ribosomal protein, large, P0 -0.0370398
RPL28 ribosomal protein L28 -0.0370163
GNAS GNAS complex locus -0.0367152
RPL32 ribosomal protein L32 -0.0364791
S100A9 S100 calcium binding protein A9 -0.0363082
RPS16 ribosomal protein S16 -0.036232
RPL34 ribosomal protein L34 -0.0361511
RPS14 ribosomal protein S14 -0.035857
LDHA lactate dehydrogenase A -0.035413
RPS21 ribosomal protein S21 -0.0346586
RPL38 ribosomal protein L38 -0.0336758
RAB7A RAB7A, member RAS oncogene family -0.0336394
ENO2 enolase 2 (gamma, neuronal) -0.0333025
RPS27 ribosomal protein S27 -0.0328437
BASP1 brain abundant, membrane attached signal protein 1 -0.0325173
RPL27A ribosomal protein L27a -0.032264
RPL35 ribosomal protein L35 -0.0319871
UGCG UDP-glucose ceramide glucosyltransferase -0.0316493
GOLGA4 golgin A4 -0.0310395
SQSTM1 sequestosome 1 -0.0305575
CTSD cathepsin D -0.0302504
RPL15 ribosomal protein L15 -0.0298698
HLA-E major histocompatibility complex, class I, E -0.029266
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0285696
SFTPA2 surfactant protein A2 -0.028186
RPL8 ribosomal protein L8 -0.0280718
RPS17 ribosomal protein S17 -0.0279344
EEF2 eukaryotic translation elongation factor 2 -0.027759
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0274808
BTG1 B-cell translocation gene 1, anti-proliferative -0.0269952
SLC38A1 solute carrier family 38, member 1 -0.0267343
RPS15 ribosomal protein S15 -0.0264228
HMGA1 high mobility group AT-hook 1 -0.0264173
RPL10A ribosomal protein L10a -0.0261744
RPL7 ribosomal protein L7 -0.0261457
VDAC1 voltage-dependent anion channel 1 -0.0260883
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0259888
ZMYND8 zinc finger, MYND-type containing 8 -0.0257595
RPS5 ribosomal protein S5 -0.025564
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0254299
PKM pyruvate kinase, muscle -0.0253115
CD63 CD63 molecule -0.0252429
RPS11 ribosomal protein S11 -0.0252392
RPL27 ribosomal protein L27 -0.0249401